DOI QR코드

DOI QR Code

Surgical Resection of Neurogenic Heterotopic Ossification around Hip Joint in Stroke Patients: A Safety and Outcome Report

  • Jae-Young Beom (Department of Orthopedic Surgery, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • WengKong Low (Orthopaedic and Traumatology Department, Hospital Kuala Lumpur) ;
  • Kyung-Soon Park (Department of Orthopedic Surgery, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Taek-Rim Yoon (Department of Orthopedic Surgery, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Chan Young Lee (Department of Orthopedic Surgery, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Hyeongmin Song (Department of Orthopedic Surgery, Chonnam National University Hwasun Hospital, Chonnam National University Medical School)
  • Received : 2023.01.10
  • Accepted : 2023.06.15
  • Published : 2023.12.31

Abstract

Purpose: Resection remains the most reliable treatment for established heterotopic ossification, despite questions regarding its effectiveness due to the potential for complications. This study evaluated the clinical outcomes and complications of neurogenic heterotopic ossification (NHO) resection in stroke patients' ankylosed hips. Materials and Methods: We retrospectively analyzed nine hip NHO resections performed on seven patients from 2010 to 2018. The pre- and postoperative range of motion of the operated hip were compared. Analysis of postoperative complications, including infection, recurrence, iatrogenic fracture, and neurovascular injury was performed. Results: The mean operative time was 132.78±21.08 minutes, with a mean hemoglobin drop of 3.06±0.82 g/dL within the first postoperative week. The mean duration of postoperative follow-up was 52.08±28.72 months for all patients. Postoperative range of motion showed improvement from preoperative. Flexion and external rotation (mean, 58.89±30.60° and 16.67±18.03°, respectively) showed the greatest gain of motion of the operated hip joint. Postoperative infections resolved in two cases through surgical debridement, and one case required conversion to total hip arthroplasty due to instability. There were no recurrences, iatrogenic fractures, or neurovascular injuries. Conclusion: Resection is a beneficial intervention for restoring the functional range of motion of the hip in order to improve the quality of life for patients with NHO and neurological disorders. We recommend performance of a minimal resection to achieve a targeted functional arc of motion in order to minimize the risk of postoperative complications.

Keywords

References

  1. Shehab D, Elgazzar AH, Collier BD. Heterotopic ossification. J Nucl Med. 2002;43:346-53. 
  2. Cipriano CA, Pill SG, Keenan MA. Heterotopic ossification following traumatic brain injury and spinal cord injury. J Am Acad Orthop Surg. 2009;17:689-97. https://doi.org/10.5435/00124635-200911000-00003 
  3. Brady RD, Shultz SR, McDonald SJ, O'Brien TJ. Neurological heterotopic ossification: current understanding and future directions. Bone. 2018;109:35-42. https://doi.org/10.1016/j.bone.2017.05.015 
  4. Gatin L, Genet F, Dinh A, Denormandie P. Postoperative infections after excision of neurogenic heterotopic ossifications at the hip: risk factors and causative organisms. Orthop Traumatol Surg Res. 2017;103:357-61. https://doi.org/10.1016/j.otsr.2017.02.001 
  5. Meiners T, Abel R, Bohm V, Gerner HJ. Resection of heterotopic ossification of the hip in spinal cord injured patients. Spinal Cord. 1997;35:443-5. https://doi.org/10.1038/sj.sc.3100415 
  6. Denormandie P, de l'Escalopier N, Gatin L, Grelier A, Genet F. Resection of neurogenic heterotopic ossification (NHO) of the hip. Orthop Traumatol Surg Res. 2018;104(1S):S121-7. https://doi.org/10.1016/j.otsr.2017.04.015 
  7. Genet F, Minooee K, Jourdan C, Ruet A, Denormandie P, Schnitzler A. Troublesome heterotopic ossification and stroke: features and risk factors. A case control study. Brain Inj. 2015;29:866-71. https://doi.org/10.3109/02699052.2015.1005133 
  8. Hajek VE. Heterotopic ossification in hemiplegia following stroke. Arch Phys Med Rehabil. 1987;68(5 Pt 1):313-4. 
  9. Varghese G, Williams K, Desmet A, Redford JB. Nonarticular complication of heterotopic ossification: a clinical review. Arch Phys Med Rehabil. 1991;72:1009-13. https://doi.org/10.5555/uri:pii:0003999391901448 
  10. Cunha DA, Camargos S, Passos VMA, Mello CM, Vaz LS, Lima LRS. Heterotopic ossification after stroke: clinical profile and severity of ossification. J Stroke Cerebrovasc Dis. 2019;28:513-20. https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.10.032 
  11. van Kuijk AA, Geurts AC, van Kuppevelt HJ. Neurogenic heterotopic ossification in spinal cord injury. Spinal Cord. 2002;40:313-26. https://doi.org/10.1038/sj.sc.3101309 
  12. Wharton GW, Morgan TH. Ankylosis in the paralyzed patient. J Bone Joint Surg Am. 1970;52:105-12. 
  13. Allard MM, Thomas RL, Nicholas RW Jr. Myositis ossificans: an unusual presentation in the foot. Foot Ankle Int. 1997;18:39-42. https://doi.org/10.1177/107110079701800108 
  14. Almangour W, Schnitzler A, Salga M, Debaud C, Denormandie P, Genet F. Recurrence of heterotopic ossification after removal in patients with traumatic brain injury: a systematic review. Ann Phys Rehabil Med. 2016;59:263-9. https://doi.org/10.1016/j.rehab.2016.03.009 
  15. de l'Escalopier N, Salga M, Gatin L, Genet F, Denormandie P. Resection of heterotopic ossification around the hip after trauma. EFORT Open Rev. 2019;4:263-8. https://doi.org/10.1302/2058-5241.4.180098 
  16. Garland DE, Orwin JF. Resection of heterotopic ossification in patients with spinal cord injuries. Clin Orthop Relat Res. 1989;(242):169-76. 
  17. Macheras GA, Lepetsos P, Leonidou A, Anastasopoulos PP, Galanakos SP, Tsiridis E. Results from the surgical resection of severe heterotopic ossification of the hip: a case series of 26 patients. Eur J Orthop Surg Traumatol. 2017;27:1097-102. https://doi.org/10.1007/s00590-017-1980-2 
  18. Brooker AF, Bowerman JW, Robinson RA, Riley LH Jr. Ectopic ossification following total hip replacement. Incidence and a method of classification. J Bone Joint Surg Am. 1973;55:1629-32. 
  19. Genet F, Kulina I, Vaquette C, et al. Neurological heterotopic ossification following spinal cord injury is triggered by macrophagemediated inflammation in muscle. J Pathol. 2015;236:229-40. https://doi.org/10.1002/path.4519 
  20. Bidner SM, Rubins IM, Desjardins JV, Zukor DJ, Goltzman D. Evidence for a humoral mechanism for enhanced osteogenesis after head injury. J Bone Joint Surg Am. 1990;72:1144-9. https://doi.org/10.2106/00004623-199072080-00004 
  21. Sullivan MP, Torres SJ, Mehta S, Ahn J. Heterotopic ossification after central nervous system trauma: a current review. Bone Joint Res. 2013;2:51-7. https://doi.org/10.1302/2046-3758.23.2000152 
  22. Baird EO, Kang QK. Prophylaxis of heterotopic ossification- an updated review. J Orthop Surg Res. 2009;4:12. https://doi.org/10.1186/1749-799X-4-12 
  23. Balboni TA, Gobezie R, Mamon HJ. Heterotopic ossification: pathophysiology, clinical features, and the role of radiotherapy for prophylaxis. Int J Radiat Oncol Biol Phys. 2006;65:1289-99. https://doi.org/10.1016/j.ijrobp.2006.03.053 
  24. Pellegrini VD Jr, Gregoritch SJ. Preoperative irradiation for prevention of heterotopic ossification following total hip arthroplasty. J Bone Joint Surg Am. 1996;78:870-81. https://doi.org/10.2106/00004623-199606000-00010 
  25. Genet F, Jourdan C, Schnitzler A, et al. Troublesome heterotopic ossification after central nervous system damage: a survey of 570 surgeries. PLoS One. 2011;6:e16632. https://doi.org/10.1371/journal.pone.0016632 
  26. Stover SL, Niemann KM, Tulloss JR. Experience with surgical resection of heterotopic bone in spinal cord injury patients. Clin Orthop Relat Res. 1991;(263):71-7. 
  27. Tyler JL, Derbekyan V, Lisbona R. Early diagnosis of myositis ossificans with Tc-99 m diphosphonate imaging. Clin Nucl Med. 1984;9:256-8. https://doi.org/10.1097/00003072-198405000-00002 
  28. Drane WE. Myositis ossificans and the three-phase bone scan. AJR Am J Roentgenol. 1984;142:179-80. https://doi.org/10.2214/ajr.142.1.179 
  29. Genet F, Ruet A, Almangour W, Gatin L, Denormandie P, Schnitzler A. Beliefs relating to recurrence of heterotopic ossification following excision in patients with spinal cord injury: a review. Spinal Cord. 2015;53:340-4. https://doi.org/10.1038/sc.2015.20 
  30. Kocaaga Z, Bal S, Gurgan A. Hemiplegia and heterotopic ossification on the non-paretic extremity: a case report. J Rehabil Med. 2007;39:500-2. https://doi.org/10.2340/16501977-0086