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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Crosstalk between RNA silencing and RNA quality control in plants

  • Yun Ju Kim (Department of Systems Biology, Yonsei University)
  • Received : 2023.03.19
  • Accepted : 2023.05.04
  • Published : 2023.06.30
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Abstract

RNAs are pivotal molecules acting as messengers of genetic information and regulatory molecules for cellular development and survival. From birth to death, RNAs face constant cellular decision for the precise control of cellular function and activity. Most eukaryotic cells employ conserved machineries for RNA decay including RNA silencing and RNA quality control (RQC). In plants, RQC monitors endogenous RNAs and degrades aberrant and dysfunctional species, whereas RNA silencing promotes RNA degradation to repress the expression of selected endogenous RNAs or exogenous RNA derived from transgenes and virus. Interestingly, emerging evidences have indicated that RQC and RNA silencing interact with each by sharing target RNAs and regulatory components. Such interaction should be tightly organized for proper cellular survival. However, it is still elusive that how each machinery specifically recognizes target RNAs. In this review, we summarize recent advances on RNA silencing and RQC pathway and discuss potential mechanisms underlying the interaction between the two machineries.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2022R1A2C100550812 and 2018R1A6A1A0302560722) and the Yonsei University Research Fund of 2022 (2022-22-0133).

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