Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Anti-Melanogenic Effect of Cannabis sativa Stem Extracts Fermented with Weissella paramesenteroides

  • Taehyun Kim (Natural Product Research Center, Korea Institute of Science and Technology (KIST)) ;
  • Jin-Woo Kim (Natural Product Research Center, Korea Institute of Science and Technology (KIST)) ;
  • Huitae Min (Natural Product Research Center, Korea Institute of Science and Technology (KIST)) ;
  • Jisu Park (Natural Product Research Center, Korea Institute of Science and Technology (KIST)) ;
  • Taejung Kim (Natural Product Research Center, Korea Institute of Science and Technology (KIST)) ;
  • Geun-Hyeong Kim (Kolmar Korea Co., Ltd.) ;
  • Byung-Joon Park (Kolmar Korea Co., Ltd.) ;
  • Jeong Kook Kim (NeoCannBio Co., Ltd.) ;
  • Young-Tae Park (Natural Product Research Center, Korea Institute of Science and Technology (KIST)) ;
  • Jin-Chul Kim (Natural Product Research Center, Korea Institute of Science and Technology (KIST)) ;
  • Jungyeob Ham (Natural Product Research Center, Korea Institute of Science and Technology (KIST))
  • Received : 2023.03.28
  • Accepted : 2023.06.26
  • Published : 2023.09.28
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Abstract

Cannabis sativa (CS) has been in the spotlight not only for its medical uses but also as a raw material for cosmetics. As fermented cosmetics are known to have various health benefits, they have been extensively researched. Here, we investigated the characteristics of CS stems fermented using various gut microbes. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay and melanin content analysis revealed that melan-a cells containing CS stems fermented with Weissella paramesenteroides (CSWP) showed considerably reduced melanin content. Additionally, CSWP downregulated the expression of several melanogenesis factors, tyrosinase-related protein-1, and tyrosinase-related protein-2. This study suggests that the anti-melanogenic effect of CSWP could provide a new basis for the development of skin-lightening agents.

Keywords

Acknowledgement

This research was supported by intramural grants (2V09620, 2Z06822) from the Korea Institute of Science and Technology (KIST), the Promotion (NO : P0016080) of Innovative Businesses for Regulation-Free Special Zones funded by the Ministry of SMEs and Startups (MSS, Korea) and the Ministry of Science and ICT (MSIT, Korea) (support program: 2021-DD-UP-0379).

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