Journal of Veterinary Science

The Korean Society of Veterinary Science (대한수의학회)
권호 표지
DOI QR코드

DOI QR Code

Open-heart surgery using Del-Nido cardioplegia in two dogs: partial atrioventricular septal defect and mitral repair

  • Won-Jong Lee (Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University) ;
  • Chang-Hwan Moon (Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University) ;
  • Wonkyoung Yoon (Guardian Angel Veterinary Hospital) ;
  • Mihyung Kim (Chungnam National University Sejong Hospital) ;
  • Woo-Jin Kim (Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University) ;
  • Kyung-Min Kim (Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University) ;
  • Haebeom Lee (Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University) ;
  • Seong-Mok Jeong (Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University) ;
  • Jae Hyeon Yu (Department of Cardiothoracic Surgery, Chungnam National University Hospital, College of Medicine, Chungnam National University) ;
  • Dae-Hyun Kim (Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University)
  • Received : 2023.03.27
  • Accepted : 2023.05.08
  • Published : 2023.05.31
Download PDF
⟨ Previous Next ⟩

Abstract

Del-Nido cardioplegia (DNc) is a single-dose cardioplegia that is widely used in human medicine because of its long duration. In this report, we describe two cases of open-heart surgery with cardiopulmonary bypass (CPB) using DNc. One dog was diagnosed with partial atrioventricular septal defect, and the other dog was diagnosed with myxomatous mitral valve disease stage D. Both dogs were treated with open-heart surgery with DNc to induce temporary cardiac arrest. No complications from DNc were observed, and the patients were discharged. Veterinary heart surgeons should consider DNc as an option for temporary cardiac arrest during open-heart surgery with CPB.

Keywords

Acknowledgement

We would like to thank Editage (www.editage.co.kr) for the English language editing.

References

  1. Misra S, Srinivasan A, Jena SS, Bellapukonda S. Myocardial protection in adult cardiac surgery with del Nido versus blood cardioplegia: a systemic review and meta-analysis. Heart Lung Circ. 2021;30(5):642-655. https://doi.org/10.1016/j.hlc.2020.10.016
  2. Ad N, Holmes SD, Massimiano PS, Rongione AJ, Fornaresio LM, Fitzgerald D. The use of del Nido cardioplegia in adult cardiac surgery: a prospective randomized trial. J Thorac Cardiovasc Surg. 2018;155(3):1011-1018  https://doi.org/10.1016/j.jtcvs.2017.09.146
  3. George G, Varsha AV, Philip MA, Vithayathil R, Srinivasan D, Sneha Princy FX, et al. Myocardial protection in cardiac surgery: del Nido versus blood cardioplegia. Ann Card Anaesth. 2020;23(4):477-484. https://doi.org/10.4103/aca.ACA_153_19
  4. Ali JM, Miles LF, Abu-Omar Y, Galhardo C, Falter F. Global cardioplegia practices: Results from the global cardiopulmonary bypass survey. J Extra Corpor Technol. 2018;50(2):83-93. https://doi.org/10.1051/ject/201850083
  5. Matte GS, del Nido PJ. History and use of del Nido cardioplegia solution at Boston Children's Hospital. J Extra Corpor Technol. 2012;44(3):98-103. https://doi.org/10.1051/ject/201244098
  6. Haider A, Khwaja IA, Khan AH, Yousaf MS, Zaneb H, Qureshi AB, et al. Efficacy of whole-blood del Nido cardioplegia compared with diluted del Nido cardioplegia in coronary artery bypass grafting: a retrospective monocentric analysis of Pakistan. Medicina (Kaunas). 2021;57(9):918.
  7. Keene BW, Atkins CE, Bonagura JD, Fox PR, Haggstrom J, Fuentes VL, et al. ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs. J Vet Intern Med. 2019;33(3):1127-1140. https://doi.org/10.1111/jvim.15488
  8. Lee WJ, Kim J, Moon CH, Eom T, Son D, Lee S, et al. Successful mitral repair in dogs by mitral annuloplasty using Hegar dilator: two case reports. J Vet Sci. 2022;23(1):e11.
  9. Dobson GP, Faggian G, Onorati F, Vinten-Johansen J. Hyperkalemic cardioplegia for adult and pediatric surgery: end of an era? Front Physiol. 2013;4(4):228.
  10. Ucak HA, Ucak D. Single-dose del Nido cardioplegia vs. blood cardioplegia in aortic valve replacement surgery. Rev Bras Cir Cardiovasc. 2021;36(2):229-236. https://doi.org/10.21470/1678-9741-2020-0063
  11. Nakao M, Morita K, Shinohara G, Kunihara T. Modified del Nido cardioplegia and its evaluation in a piglet model. Semin Thorac Cardiovasc Surg. 2021;33(1):84-92. https://doi.org/10.1053/j.semtcvs.2020.03.002
  12. Charette K, Gerrah R, Quaegebeur J, Chen J, Riley D, Mongero L, et al. Single dose myocardial protection technique utilizing del Nido cardioplegia solution during congenital heart surgery procedures. Perfusion. 2012;27(2):98-103. https://doi.org/10.1177/0267659111424788
  13. D'Angelo AM, Nemeth S, Wang C, Kossar AP, Takeda K, Takayama H, et al. Re-dosing of del Nido cardioplegia in adult cardiac surgery requiring prolonged aortic cross-clamp. Interact Cardiovasc Thorac Surg. 2022;34(4):556-563. https://doi.org/10.1093/icvts/ivab310
  14. Talwar S, Bhoje A, Sreenivas V, Makhija N, Aarav S, Choudhary SK, et al. Comparison of del Nido and St Thomas cardioplegia solutions in pediatric patients: a prospective randomized clinical trial. Semin Thorac Cardiovasc Surg. 2017;29(3):366-374. https://doi.org/10.1053/j.semtcvs.2017.08.017
  15. Ler A, Sazzad F, Ong GS, Kofidis T. Comparison of outcomes of the use of del Nido and St. Thomas cardioplegia in adult and paediatric cardiac surgery: a systematic review and meta-analysis. Perfusion. 2020;35(8):724-735. https://doi.org/10.1177/0267659120919350