Journal of Veterinary Science

The Korean Society of Veterinary Science (대한수의학회)
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Lymphopenia predicts reduced survival in canine hepatocellular carcinoma

  • Jose Israel Suarez-Rodriguez (Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine) ;
  • Chin-Chi Liu (Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine) ;
  • Shannon Dehghanpir (Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine) ;
  • Andrea N. Johnston (Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine)
  • Received : 2022.10.23
  • Accepted : 2023.03.12
  • Published : 2023.05.31
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Abstract

Platelet to lymphocyte ratio (PLR) is a prognostic marker in human hepatocellular carcinoma (HCC) however, its utility in canine HCC has not been explored. The aim of the study was to determine if PLR could predict survival outcomes in 42 dogs with HCC. PLR was not a significant predictive factor (p = 0.15) but lymphopenia alone was significantly correlated with a reduced probability of survival (p = 0.024). Further studies are needed to evaluate if peripheral lymphocyte count mirrors that of the tumor microenvironment in canine HCC.

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Acknowledgement

We would like to acknowledge the families and primary veterinarians of the dogs included in the study for providing patient information. We would also like to thank Medical Record Office personnel for assisting with the recovery of non-electronic medical records. Finally, thank you to Priscilla Devora for assistance identifying patients from the database of the Louisiana Animal Disease Diagnostic Laboratory.

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