CELLMED (셀메드)

Cellmed Orthocellular Medicine and Pharmaceutical Association (셀메드 세포교정의약학회)
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Protective effects of Hydro-alcoholic extract of the roots of Kasondi (Cassia occidentalis L.) against gentamicin-induced nephrotoxicity in albino Wistar rats

  • Jwariya Shamim (Regional Research Institute of Unani Medicine, Srinagar, Jammu & Kashmir (NABH Accredited), CCRUM, Ministry of AYUSH) ;
  • Athar Parvez Ansari (Regional Research Institute of Unani Medicine, Chennai, Tamil Nadu (NABH Accredited), CCRUM, Ministry of AYUSH) ;
  • Pankaj Goswami (Division of Veterinary Pathology, Sher-e-Kashmir University of Agriculture Sciences and Technology of Kashmir) ;
  • Seema Akbar (Regional Research Institute of Unani Medicine, Srinagar, Jammu & Kashmir (NABH Accredited), CCRUM, Ministry of AYUSH) ;
  • Huzaifa Ansari (Regional Research Institute of Unani Medicine, Srinagar, Jammu & Kashmir (NABH Accredited), CCRUM, Ministry of AYUSH) ;
  • Abdul Wadud (National Institute of Unani Medicine) ;
  • Pervaiz Ahmad Dar (Department of AYUSH, Jammu & Kashmir)
  • Received : 2023.04.04
  • Accepted : 2023.05.31
  • Published : 2023.05.31
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Abstract

Objectives: Cassia occidentalis L. is a weed belonging to the Caesalpiniaceae family. The root of this medicinal plant is used for the treatment of various ailments, including kidney diseases. The present study was aimed at evaluating the nephroprotective effects of HAE of the roots of Cassia occidentalis L. against gentamicininduced renal toxicity in albino Wistar rats. Methods: The renal toxicity was induced by subcutaneous administration of gentamicin at 100 mg/kg in the rats belonging to the disease control and treatment groups from the 4th to the 8th day. The rats in the treatment group received HAE of the roots of Cassia occidentalis L. at 67 mg/kg b. w. orally for 8 days, while no treatment was given to the rats in the disease control and plain control groups. At the end of the experiment, renal biomarkers viz; s. creatinine, b. urea, and s. uric acid, were investigated. The histopathological examination of the kidney specimens was also carried out. Results: The results of the present study revealed that renal function biomarkers such as s. creatinine, b. urea, and s. uric acid were significantly reduced in the rats of the treatment group as compared to those of the disease control group. Moreover, the histoarchitecture reports of the treatment group's kidney specimens showed significant improvements. Conclusion: The results suggested that the HAE of Cassia occidentalis L. roots promisingly prevented kidney injury in gentamicin-induced nephrotoxic rats. This effect might be due to improved clearance of gentamicin from the renal tubule and decreased generation of reactive oxygen species (ROS).

Keywords

Acknowledgement

We are indebted to the Central Council for Research in Unani Medicine, Ministry of Ayush, Govt. of India, for providing financial support for the study.

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