Safety and Health at Work

Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency (산업안전보건연구원)
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The Effects of Resveratrol on Silica-Induced Lung Oxidative Stress and Inflammation in Rat

  • Maryam Esfahani (Nutrition Health Research Center, Hamadan University of Medical Sciences) ;
  • Amir Hossein Rahbar (Ayatollah Bahari Hospital, Hamadan University of Medical Sciences) ;
  • Sara Soleimani Asl (Department of Anatomical Sciences, School of Medicine Endometrium and Endometriosis Research Center, Hamadan University of Medical Sciences) ;
  • Saed Bashirian (Research Center for Health Sciences, School of Public Health, Hamadan University of Medical Sciences) ;
  • Effat Sadat Mir Moeini (Center of Excellence for Occupational Health, Research Center for Health Sciences, School of Public Health, Hamadan University of Medical Sciences) ;
  • Fereshteh Mehri (Nutrition Health Research Center, Center of Excellence for Occupational Health, Research Center for Health Sciences, School of Public Health, Hamadan University of Medical Sciences)
  • Received : 2022.06.24
  • Accepted : 2023.02.06
  • Published : 2023.03.30
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Abstract

Background: Chronic exposure to silica is related with the provocation of an inflammatory response and oxidative stress mechanism. Vitamin D has multiple benefits in biological activities particularly respiratory system disease. Method: In this research, 20 male Wistar rats were randomly allocated into four groups (5 rats /group) as follow: Group1 received saline as (negative control) group. The group 2 received a single IT instillation of silica (positive control) group; the group 3 was co-administrated with single IT silica and Vitamin D (20 mg/kg/day) daily for a period of 90 days. The rats of group 4 received Vitamin D daily for a period of 90 days. Results: Silica significantly increased serum and lung total Oxidant Status (TOS). Meanwhile, silica reduced serum and lung total antioxidant capacity (TAC), GSH and tumor necrosis factor-α (TNF-a). Vitamin D treatment meaningfully reversed oxidative stress, antioxidants status and inflammatory response. Also, Vitamin D improved histopathological changes caused by silica. Conclusion: These findings indicate that Vitamin D exerts protective effects against silica-induced lung injury. It seems that Vitamin D has potential use as a therapeutic object for silica induced lung injure.

Keywords

Acknowledgement

The authors would appreciate the Deputy of Research and Technology, Hamadan University of Medical Sciences, for financial support of the study.

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