DOI QR코드

DOI QR Code

하지 감각이상 및 통증을 호소하는 당뇨병성 다발신경병증 환자에 대한 복합 한의치험 1례

Case Report: Lower Extremity Paresthesia and Pain with Diabetic Polyneuropathy Combated with Complex Korean Medical Treatment

  • 정성훈 (경희대학교 대학원 임상한의학과) ;
  • 이영선 (경희대학교 대학원 임상한의학과) ;
  • 성시윤 (경희대학교 한방병원 순환신경내과) ;
  • 이한결 (경희대학교 대학원 임상한의학과) ;
  • 조기호 (경희대학교 대학원 임상한의학과) ;
  • 문상관 (경희대학교 대학원 임상한의학과) ;
  • 정우상 (경희대학교 대학원 임상한의학과) ;
  • 권승원 (경희대학교 대학원 임상한의학과)
  • Seong-Hoon Jeong (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Young-Seon Lee (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Si-Yun Sung (Dept. of Cardiology and Neurology, Kyung Hee University Korean Medicine Hospital) ;
  • Han-Gyul Lee (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Ki-Ho Cho (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Sang-Kwan Moon (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Woo-Sang Jung (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Seungwon Kwon (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 투고 : 2023.04.07
  • 심사 : 2023.05.22
  • 발행 : 2023.05.30

초록

Background: Diabetic polyneuropathy is the most common complication in diabetics, occurring in 50% of all cases. About 10-20% of all diabetics are accompanied by neurological pain, showing a tendency to increase with age. Clinical aspects are very diverse, from mild abnormalities on nerve conduction tests to severe abnormalities in all sensory, motor, and autonomic nerves; however, sensory symptoms usually precede motor symptoms. Patients typically express sensory symptoms, such as positive and negative symptoms, which decrease the quality of life and have marked clinical implications, such as increased morbidity and mortality. Although Western medical drugs, such as tricyclic antidepressants, anticonvulsants, and narcotic analgesics, are used for diabetic polyneuropathy, a standard treatment has not been established. Case report: A 65-year-old male with paresthesia and pain due to diabetic polyneuropathy was treated with Uchashinki-hwan, acupuncture, electroacupuncture, moxibustion, and Jungsongouhyul pharmacopuncture for 10 days. We used the Toronto Clinical Neuropathy Scoring System, EuroQol-5 Dimension, and Visual Analog Scale to evaluate symptoms. Subsequently, the Neuropathy Scoring System, EuroQol-5 Dimension, and subjective discomfort improved. Conclusion: The present case report suggests that combined Korean medicine treatment might be an effective treatment for paresthesia and pain with diabetic polyneuropathy. Several follow-up studies should be conducted to clarify the effectiveness of the treatment.

키워드

참고문헌

  1. Chun SW, Ko KS. Sumary of the Update to the Diabetic Neuropathy Management Guidebook. The Journal of Korean Diabetes 2012;13(3):115-23. https://doi.org/10.4093/jkd.2012.13.3.115
  2. Moon SS. Diagnosis and Management of Diabetic Peripheral Neuropathy. J Korean Diabetes 2018;19(3):153-9. https://doi.org/10.4093/jkd.2018.19.3.153
  3. Abuaisha BB, Costanzi JB, Boulton AJ. Acupuncture for the treatment of chronic painful peripheral diabetic neuropathy : a long-term study. Diabetes research and clinical practice 1998;39(2):115-21. https://doi.org/10.1016/S0168-8227(97)00123-X
  4. Cho KH, Jung S, Lee KJ. A Case of Yukmijihwanghwan' effect on Diabetic neuropathy. Korean J Orient Int Med 1999;20(1):286-90.
  5. Kwon YK, Choi KR, Lee JS, Lee BC, Ahn YM, Ahn SY, et al. Two Cases of Diabetic Peripheral Polyneuropathy Improved by Bogan-tang. J Korean Oriental Med 2002;23(1):170-7.
  6. Park SK, Kwon EH, Shin HC, Kang SB. One Case of Diabetic Peripheral Polyneuropathy Improved by Binsosan-gamibang. Journal of Internal Korean Medicine 2005;26(4):935-40.
  7. Kim JM, Cho CS, Kim CJ. Clinical Study of 8 Diabetic Patients with Paresthesia. Journal of Internal Korean Medicine 2010;31(2):372-9.
  8. Woo JM, Kang AR, Lee MR, Kim SB, Jung WS, Moon SK, et al. Case Report of diabetic neuropathy Treated with Palmijihwang-tang, Acupuncture, and Moxibustion. J Int Korean Med 2016;37(2):232-6.
  9. Park GH, Jeon SH, Kim JW. A Case study of a Soyangin Patient with Diabetic neuropathy. J Sasang constitut Med 2021;33(4):65-77.
  10. Jeon GR, Yim TB, Hwang YC, Choi JW, Park SU, Park JM, et al. A Case Report on Diabetic Neuropathy Treated with Bee Venom Acupuncture and Combined Korean Medicine. J Int Korean Med 2021;42(5):958-66. https://doi.org/10.22246/jikm.2021.42.5.958
  11. Yoo JH, Lee DE, Kim DH, Ahn SY, Lee BC, Ahn YM. A Case Report of Diabetic neuropathy treated with Korean Medicine. J Int Korean Med 2017;38(5):675-80. https://doi.org/10.22246/jikm.2017.38.5.675
  12. Dimitrova A, Murchison C, Oken B. Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis. J Altern Complement Med 2017 Mar 1;23(3):164-79. https://doi.org/10.1089/acm.2016.0155
  13. Shin KM, Lee SH, Lee EY, Kim CH, Kang JW, Lee CK, et al. Electroacupuncture for Painful Diabetic peripheral Neuropathy: A Multicenter, Randomized, Assessor-Blinded, controlled Trial. Diabetes Care 2018;41(10):e141-2. https://doi.org/10.2337/dc18-1254
  14. Zhao JL, Li ZR. Clinical observation on mild-warm moxibustion for treatment of diabetic peripheral neuropathy. Zhongguo Zhen Jiu 2008 Jan;28(1):13-6.
  15. Jung MJ. Effects of Ohyaksungi-san(Wuyaoshungi-san) and Jungsongouhyul Pharmacopuncture on Pain reduction and Nerve Regeneration after Crush Injury in Rat Sciatic Nerve. Journal of Korean Medicine Rehabilitation 2009;19(2):51-72.
  16. Bril V, Perkins BA. Validation of the Toronto Clinical Scoring System for diabetic polyneuropathy. Diabetes Care 2002;25(11):2048-52. https://doi.org/10.2337/diacare.25.11.2048
  17. Abraham A, Barnett C, Katzberg HD, Lovblom LE, Perkins BA, Bril V. Toronto Clinical Neuropathy Score is valid for a wide spectrum of polyneuropathies. Eur J Neurol 2018;25(3):484-90. https://doi.org/10.1111/ene.13533
  18. Lin MT, Lee LJ, Chao CC, Hsieh ST. Quality of life in polyneuropathy: association with biomarkers of small fiber impairment. Health Qual Life Outcomes 2015;13:169.
  19. Said G. Diabetic neuropathy-a review. Nature Reviews. Neurology 2007 Jun 1;3(6):331-40.
  20. Minn YK, Kim SM. Diagnosis and Treatment of Neuropathic Pain. J Korean Med Assoc 2008;51(12):1139-48. https://doi.org/10.5124/jkma.2008.51.12.1139
  21. Park SH, Kwon EH, Shin HC, Kang SB. One Case of Diabetic Peripheral Polyneuropathy Improved by Binsosan-gamibang. Journal of Internal Korean Medicine 2005;26(4):935-40.
  22. Ang L, Jaiswal M, Martin C, Pop-Busui R. Glucose control and diabetic neuropathy: lessons from recent large clinical trials. Curr Diab Rep 2014;14(9):528.
  23. Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, Lafont S, Bergeonneau C, Kassai B, et al. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ 2011;343:d4169.
  24. Ishibashi F, Taniguchi M, Kosaka A, Uetake H, Tavakoli M. Improvement in neuropathy outcomes with normalizing HbA1c in patients with type 2 diabetes. Diabetes Care 2019;42(1):110-8. https://doi.org/10.2337/dc18-1560
  25. Oh JY. Peripheral neuropathy. The Korean Journal of Medicine 2016;90(5):394-401.
  26. 임장신 외 6인. 중풍(뇌졸중)환자의 이상감각에 대한 임상적 연구. 한방내과학회지 1999;19(2별책부록):29-40.
  27. Motoo Y, Arai I, Hyodo I, Tsutani K. Current status of Kampo(Japanese herbla) medicines in Japanese clinical practice guidelines. Complementary Therapies in Medicine 2009;17(3):147-54.
  28. Tawata M, Kurihara A, Nitta K, Iwase E, Gan N, Onaya T. The effects of Goshajinkigan, a herbal medicine, on subjective symptoms and vibratory threshold in patients with diabetic neuropathy. Diabetes Research and Clinical Practice 1994;26(2):121-8. https://doi.org/10.1016/0168-8227(94)90149-X
  29. Suzuki Y, Goto K, Ishige A, Komatsu Y, Kamei J. Antinociceptive Effect of Gosha-jinki-gan, a Kampo Medicine, in Streptozotocin-Induced Diabetic Mice. Jpn J Pharmacol 1999;79(2):169-75. https://doi.org/10.1254/jjp.79.169
  30. Zijing X, Fangyuan C, Yihuai Z, Lijun B. Acupunctrue enhances effective connectivity between cerebellum and primary sensorimotor cortex in patients with stable recovery stroke. Evidence-Based Complementary and Alternative Medicine 2014;2014:603909.
  31. Lou XF, Yang XD, Jiang SH, Sun CY, Zhang RF. Study on angle and depth of needle insertion in acupuncture at Zusanli (ST 36). Zhongguo Zhen Jiu 2006;26(7):483-6.
  32. Liang X Bin, Liu XY, Li FQ, Luo Y, Lu J, Zhang WM, et al. Long-Term High-Frequency Electro-Acupuncture Stimulation Prevents Neuronal Degeneration and up-Regulates BDNF MRNA in the Substantia Nigra and Ventral Tegmental Area Following Medial Forebrain Bundle Axotomy. Mol Brain Res 2002;108(1-2):51-9. https://doi.org/10.1016/S0169-328X(02)00513-2
  33. Dimitrova A. Introducing a Standardized Acupuncture Protocol for Peripheral Neuropathy: A Case Sereis. Med Acupunct 2017 Dec 1;29(6):352-65. https://doi.org/10.1089/acu.2017.1242
  34. Kim JH, Min BI, Na HS, Park DS. Relievingeffects of electroacupuncture on mechanical allodyniain neuropathic pain model of inferior caudal trunkinjury in rat: mediation by spinal opioid receptors. Brain research 2004;998(2):230-6. https://doi.org/10.1016/j.brainres.2003.11.045
  35. Zhou W, Lei R, Zou C, Yue YX, Luo Q, Zhang CS, et al. Analgesic Effect of Moxibustion with Different Temperatureon Inflammatory and Neuropathic Pain Mice:A Comparative Study. Evid Based Complement Alternat Med 2017;2017:4373182.