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Clinical Feature and General Management of Post-Hemorrhagic Hydrocephalus in Premature Infants

  • Shunsuke Ichi (Department of Neurosurgery, Japanese Red Cross Medical Center)
  • 투고 : 2023.03.11
  • 심사 : 2023.04.05
  • 발행 : 2023.05.01

초록

Recently, the survival of the high-risk population of preterm infants has steadily improved, and the severity of prematurity is a growing threat of gestational-age-related fatal conditions. Posthemorrhagic hydrocephalus (PHH) is the most common but serious neurological complication in premature infants, which can have life-threatening consequences during the acute phase in the neonatal period and life-long psychomotor and cognitive sequelae in their later life. Although neonatologists, pediatric neurologists, and pediatric neurosurgeons have investigated a diversified strategy for several decades, a consensus on the best management of PHH in premature infants still must be reached. Several approaches have tried to reduce the incidence of intraventricular hemorrhage (IVH) and mitigate the effect of IVH-related hydrocephalus. This paper reviews and discusses the clinical feature of PHH in premature infants, general/nonsurgical management of prematurity for IVH prevention, and posthemorrhagic management, and how and when to intervene.

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참고문헌

  1. Abu-Shaweesh JM, Almidani E : PDA: does it matter? Int J Pediatr Adolesc Med 7 : 9-12, 2020. Erratum in : Int J Pediatr Adolesc Med 7 : 212, 2020
  2. Al-Wassia H, Shah PS : Efficacy and safety of umbilical cord milking at birth: a systematic review and meta-analysis. JAMA Pediatr 169 : 18-25, 2015 https://doi.org/10.1001/jamapediatrics.2014.1906
  3. Aly H, Hammad TA, Essers J, Wung JT : Is mechanical ventilation associated with intraventricular hemorrhage in preterm infants? Brain Dev 34 : 201-205, 2012 https://doi.org/10.1016/j.braindev.2011.04.006
  4. Aly H, Massaro AN, Patel K, El-Mohandes AA : Is it safer to intubate premature infants in the delivery room? Pediatrics 115 : 1660-1665, 2005 https://doi.org/10.1542/peds.2004-2493
  5. Bada HS, Green RS, Pourcyrous M, Leffler CW, Korones SB, Magill HL, et al. : Indomethacin reduces the risks of severe intraventricular hemorrhage. J Pediatr 115 : 631-637, 1989 https://doi.org/10.1016/S0022-3476(89)80300-2
  6. Bandstra ES, Montalvo BM, Goldberg RN, Pacheco I, Ferrer PL, Flynn J, et al. : Prophylactic indomethacin for prevention of intraventricular hemorrhage in premature infants. Pediatrics 82 : 533-542, 1988 https://doi.org/10.1542/peds.82.4.533
  7. Been JV, Degraeuwe PL, Kramer BW, Zimmermann LJ : Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis. BJOG 118 : 113-122, 2011 https://doi.org/10.1111/j.1471-0528.2010.02751.x
  8. Bolt RJ, van Weissenbruch MM, Lafeber HN, Delemarre-van de Waal HA : Glucocorticoids and lung development in the fetus and preterm infant. Pediatr Pulmonol 32 : 76-91, 2001 https://doi.org/10.1002/ppul.1092
  9. Cayabyab R, McLean CW, Seri I : Definition of hypotension and assessment of hemodynamics in the preterm neonate. J Perinatol 29 Suppl 2 : S58-S62, 2009 https://doi.org/10.1038/jp.2009.29
  10. Chapman K, Holmes M, Seckl J : 11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. Physiol Rev 93 : 1139-1206, 2013 https://doi.org/10.1152/physrev.00020.2012
  11. Christian EA, Jin DL, Attenello F, Wen T, Cen S, Mack WJ, et al. : Trends in hospitalization of preterm infants with intraventricular hemorrhage and hydrocephalus in the United States, 2000-2010. J Neurosurg Pediatrics 17 : 260-269, 2016 https://doi.org/10.3171/2015.7.PEDS15140
  12. Cizmeci MN, Groenendaal F, Liem KD, van Haastert IC, Benavente-Fernandez I, van Straaten HLM, et al. : Randomized controlled early versus late ventricular intervention study in posthemorrhagic ventricular dilatation: outcome at 2 years. J Pediatr 226 : 28-35.e3, 2020 https://doi.org/10.1016/j.jpeds.2020.08.014
  13. Cizmeci MN, Khalili N, Claessens NHP, Groenendaal F, Liem KD, Heep A, et al. : ELVIS study group. Assessment of brain injury and brain volumes after posthemorrhagic ventricular dilatation: a nested substudy of the randomized controlled ELVIS trial. J Pediatr 208 : 191-197.e2, 2019 https://doi.org/10.1016/j.jpeds.2018.12.062
  14. Colan SD, Borow KM, Neumann A : Left ventricular end-systolic wall stress-velocity of fiber shortening relation: a load-independent index of myocardial contractility. J Am Coll Cardiol 4 : 715-724, 1984 https://doi.org/10.1016/S0735-1097(84)80397-6
  15. Davies MW, Swaminathan M, Chuang SL, Betheras FR : Reference ranges for the linear dimensions of the intracranial ventricles in preterm neonates. Arch Dis Child Fetal Neonatal Ed 82 : F218-F223, 2000 https://doi.org/10.1136/fn.82.3.F218
  16. de Vries LS, Groenendaal F, Liem KD, Heep A, Brouwer AJ, van 't Verlaat E, et al. : Treatment thresholds for intervention in posthaemorrhagic ventricular dilation: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 104 : F70-F75, 2019 https://doi.org/10.1136/archdischild-2017-314206
  17. De Vries LS, Pierrat V, Minami T, Smet M, Casaer P : The role of short latency somatosensory evoked responses in infants with rapidly progressive ventricular dilatation. Neuropediatrics 21 : 136-139, 1990 https://doi.org/10.1055/s-2008-1071480
  18. du Plessis AJ : The role of systemic hemodynamic disturbances in prematurity-related brain injury. J Child Neurol 24 : 1127-1140, 2009 https://doi.org/10.1177/0883073809339361
  19. El-Dib M, Limbrick DD Jr, Inder T, Whitelaw A, Kulkarni AV, Warf B, et al. : Management of post-hemorrhagic ventricular dilatation in the infant born preterm. J Pediatr 226 : 16-27.e3, 2020 https://doi.org/10.1016/j.jpeds.2020.07.079
  20. Ellenbogen JR, Waqar M, Pettorini B : Management of post-haemorrhagic hydrocephalus in premature infants. J Clin Neurosci 31 : 30-34, 2016 https://doi.org/10.1016/j.jocn.2016.02.026
  21. Fowlie PW, Davis PG, McGuire W : Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants. Cochrane Database Syst Rev (7) : CD000174, 2010
  22. Ghazi-Birry HS, Brown WR, Moody DM, Challa VR, Block SM, Reboussin DM : Human germinal matrix: venous origin of hemorrhage and vascular characteristics. AJNR Am J Neuroradiol 18 : 219-229, 1997
  23. Gilard V, Tebani A, Bekri S, Marret S : Intraventricular hemorrhage in very preterm infants: a comprehensive review. J Clin Med 9 : 2447, 2020
  24. Gilstrap LC, Christensen R, Clewell WH, D'Alton ME, Davidson EC Jr, Escobedo MB, et al. : Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH consensus development panel on the effect of corticosteroids for fetal maturation on perinatal outcomes. JAMA 273 : 413-418, 1995 https://doi.org/10.1001/jama.1995.03520290065031
  25. Guzzetta F, Shackelford GD, Volpe S, Perlman JM, Volpe JJ : Periventricular intraparenchymal echodensities in the premature newborn: critical determinant of neurologic outcome. Pediatrics 78 : 995-1006, 1986 https://doi.org/10.1542/peds.78.6.995
  26. Hamrick SEG, Sallmon H, Rose AT, Porras D, Shelton EL, Reese J, et al. : Patent ductus arteriosus of the preterm infant. Pediatrics 146 : e20201209, 2020
  27. Hill A : Neurological and Neuromuscular Disorders in MacDonald MG, Seshia MMK, Mullett MD (eds) : Avery's Neonatology Pathophysiology & Management of the Newborn, ed 6. Philadelphia : Lippincott William & Wilkins, 2005, pp1384-1409
  28. Hosono S, Mugishima H, Takahashi S, Takahashi S, Masaoka N, Yamamoto T, et al. : One-time umbilical cord milking after cord cutting has same effectiveness as multiple-time umbilical cord milking in infants born at <29 weeks of gestation: a retrospective study. J Perinatol 35 : 590-594, 2015 https://doi.org/10.1038/jp.2015.15
  29. Huang J, Meng J, Choonara I, Xiong T, Wang Y, Wang H, et al. : Antenatal infection and intraventricular hemorrhage in preterm infants: a metaanalysis. Medicine (Baltimore) 98 : e16665, 2019
  30. Ikeda T, Amizuka T, Ito Y, Mikami R, Matsuo K, Kawamura N, et al. : Changes in the perfusion waveform of the internal cerebral vein and intraventricular hemorrhage in the acute management of extremely lowbirth-weight infants. Eur J Pediatr 174 : 331-338, 2015 https://doi.org/10.1007/s00431-014-2396-1
  31. Ikeda T, Ito Y, Mikami R, Matsuo K, Kawamura N, Yamoto A, et al. : Fluctuations in internal cerebral vein and central side veins of preterm infants. Pediatr Int 63 : 1319-1326, 2021 https://doi.org/10.1111/ped.14638
  32. Ikeda T, Ito Y, Mikami R, Matsuo K, Kawamura N, Yamoto A : Hemodynamics of infants with strong fluctuations of internal cerebral vein. Pediatr Int 61 : 475-481, 2019 https://doi.org/10.1111/ped.13828
  33. International PHVD Drug Trial Group : International randomised controlled trial of acetazolamide and furosemide in posthaemorrhagic ventricular dilatation in infancy. Lancet 352 : 433-440, 1998 https://doi.org/10.1016/S0140-6736(97)12390-X
  34. Isayama T : The clinical management and outcomes of extremely preterm infants in Japan: past, present, and future. Transl Pediatr 8 : 199-211, 2019 https://doi.org/10.21037/tp.2019.07.10
  35. Johnson A, Wincott E, Grant A, Elbourne D : Randomised trial of early tapping in neonatal posthaemorrhagic ventricular dilatation: results at 30 months. Arch Dis Child Fetal Neonatal Ed 71 : F147, 1994
  36. Johnson S, Marlow N : Preterm birth and childhood psychiatric disorders. Pediatr Res 69(5 Pt 2) : 11R-18R, 2011 https://doi.org/10.1203/PDR.0b013e318212faa0
  37. Katheria AC, Truong G, Cousins L, Oshiro B, Finer NN : Umbilical cord milking versus delayed cord clamping in preterm infants. Pediatrics 136 : 61-69, 2015 https://doi.org/10.1542/peds.2015-0368
  38. Kazan S, Gura A, Ucar T, Korkmaz E, Ongun H, Akyuz M : Hydrocephalus after intraventricular hemorrhage in preterm and low-birth weight infants: analysis of associated risk factors for ventriculoperitoneal shunting. Surg Neurol 2 (64 Suppl) : S77-S81; discussion S81, 2005
  39. Kempley ST, Gamsu HR : Changes in cerebral artery blood flow velocity after intermittent cerebrospinal fluid drainage. Arch Dis Child 69(1 Spec No) : 74-76, 1993 https://doi.org/10.1136/adc.69.1_Spec_No.74
  40. Kenet G, Kuperman AA, Strauss T, Brenner B : Neonatal IVH--mechanisms and management. Thromb Res 127 Suppl 3 : S120-S122, 2011 https://doi.org/10.1016/S0049-3848(11)70032-9
  41. Kennedy CR, Ayers S, Campbell MJ, Elbourne D, Hope P, Johnson A : Randomized, controlled trial of acetazolamide and furosemide in posthemorrhagic ventricular dilation in infancy: follow-up at 1 year. Pediatrics 108 : 597-607, 2001 https://doi.org/10.1542/peds.108.3.597
  42. Kidokoro H, Neil JJ, Inder TE : New MR imaging assessment tool to define brain abnormalities in very preterm infants at term. AJNR Am J Neuroradiol 34 : 2208-2214, 2013 https://doi.org/10.3174/ajnr.A3521
  43. Klebermass-Schrehof K, Rona Z, Waldhor T, Czaba C, Beke A, Weninger M, et al. : Can neurophysiological assessment improve timing of intervention in posthaemorrhagic ventricular dilatation? Arch Dis Child Fetal Neonatal Ed 98 : F291-F297, 2013 https://doi.org/10.1136/archdischild-2012-302323
  44. Kuban K, Teele RL : Rationale for grading intracranial hemorrhage in premature infants. Pediatrics 74 : 358-363, 1984 https://doi.org/10.1542/peds.74.3.358
  45. Leijser LM, Miller SP, van Wezel-Meijler G, Brouwer AJ, Traubici J, van Haastert IC, et al. : Posthemorrhagic ventricular dilatation in preterm infants: when best to intervene? Neurology 90 : e698-e706, 2018 https://doi.org/10.1212/WNL.0000000000004984
  46. Leonard JR, Limbrick DD Jr : Intraventricular Hemorrhage and Post-Hemorrhagic Hydrocephalus in Albright AL, Pollack IF, Adelson PD (eds) : Principles and Practice of Pediatric Neurosurgery, ed 3. New York : Thieme Medical Publishers, Inc., 2015, pp137-144
  47. Levene MI : Measurement of the growth of the lateral ventricles in preterm infants with real-time ultrasound. Arch Dis Child 56 : 900-904, 1981 https://doi.org/10.1136/adc.56.12.900
  48. Mazzola CA, Choudhri AF, Auguste KI, Limbrick DD Jr, Rogido M, Mitchell L, et al. : Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 2: management of posthemorrhagic hydrocephalus in premature infants. J Neurosurg Pediatr 14 Suppl 1 : 8-23, 2014 https://doi.org/10.3171/2014.7.PEDS14322
  49. McGoldrick E, Stewart F, Parker R, Dalziel SR : Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev (12) : CD004454, 2020
  50. Ment LR, Duncan CC, Ehrenkranz RA, Kleinman CS, Taylor KJ, Scott DT, et al. : Randomized low-dose indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates. J Pediatr 112 : 948-955, 1988 https://doi.org/10.1016/S0022-3476(88)80225-7
  51. Ment LR, Oh W, Ehrenkranz RA, Phillip AG, Vohr B, Allan W, et al. : Low-dose indomethacin therapy and extension of intraventricular hemorrhage: a multicenter randomized trial. J Pediatr 124 : 951-955, 1994 https://doi.org/10.1016/S0022-3476(05)83191-9
  52. Miyata M, Toyoshima K, Yoda H, Murase M, Kawato H, Yamamoto K, et al. : Extensive use of vasodilator agents and functional echocardiography to monitor extremely-low-birth-weight infants in Japan. J Neonatal Perinatal Med 9 : 261-269, 2016 https://doi.org/10.3233/NPM-16915113
  53. Mukerji A, Shah V, Shah PS : Periventricular/intraventricular hemorrhage and neurodevelopmental outcomes: a meta-analysis. Pediatrics 136 : 1132-1143, 2015 https://doi.org/10.1542/peds.2015-0944
  54. Murphy BP, Inder TE, Rooks V, Taylor GA, Anderson NJ, Mogridge N, et al. : Posthaemorrhagic ventricular dilatation in the premature infant: natural history and predictors of outcome. Arch Dis Child Fetal Neonatal Ed 87 : F37-F41, 2002 https://doi.org/10.1136/fn.87.1.F37
  55. Norooz F, Urlesberger B, Giordano V, Klebermasz-Schrehof K, Weninger M, Berger A, et al. : Decompressing posthaemorrhagic ventricular dilatation significantly improves regional cerebral oxygen saturation in preterm infants. Acta Paediatr 104 : 663-669, 2015 https://doi.org/10.1111/apa.12942
  56. Olischar M, Klebermass K, Hengl B, Hunt RW, Waldhoer T, Pollak A, et al. : Cerebrospinal fluid drainage in posthaemorrhagic ventricular dilatation leads to improvement in amplitude-integrated electroencephalographic activity. Acta Paediatr 98 : 1002-1009, 2009 https://doi.org/10.1111/j.1651-2227.2009.01252.x
  57. Papile LA, Burstein J, Burstein R, Koffler H : Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 92 : 529-534, 1978 https://doi.org/10.1016/S0022-3476(78)80282-0
  58. Park J, Yoon SJ, Han J, Song IG, Lim J, Shin JE, et al. : Patent ductus arteriosus treatment trends and associated morbidities in neonates. Sci Rep 11 : 10689, 2021
  59. Payne AH, Hintz SR, Hibbs AM, Walsh MC, Vohr BR, Bann CM, et al. : Neurodevelopmental outcomes of extremely low-gestational-age neonates with low-grade periventricular-intraventricular hemorrhage. JAMA Pediatr 167 : 451-459, 2013 https://doi.org/10.1001/jamapediatrics.2013.866
  60. Rabe H, Gyte GM, Diaz-Rossello JL, Duley L : Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes. Cochrane Database Syst Rev 9 : CD003248, 2019
  61. Rabe H, Jewison A, Fernandez Alvarez R, Crook D, Stilton D, Bradley R, et al. : Milking compared with delayed cord clamping to increase placental transfusion in preterm neonates: a randomized controlled trial. Obstet Gynecol 117(2 Pt 1) : 205-211, 2011 https://doi.org/10.1097/AOG.0b013e3181fe46ff
  62. Riskin A, Riskin-Mashiah S, Bader D, Kugelman A, Lerner-Geva L, Boyko V, et al. : Delivery mode and severe intraventricular hemorrhage in single, very low birth weight, vertex infants. Obstet Gynecol 112 : 21-28, 2008 https://doi.org/10.1097/AOG.0b013e31817cfdf1
  63. Robinson S : Neonatal posthemorrhagic hydrocephalus from prematurity: pathophysiology and current treatment concepts. J Neurosurg Pediatr 9 : 242-258, 2012 https://doi.org/10.3171/2011.12.PEDS11136
  64. Roze E, Kerstjens JM, Maathuis CG, ter Horst HJ, Bos AF : Risk factors for adverse outcome in preterm infants with periventricular hemorrhagic infarction. Pediatrics 122 : e46-e52, 2008 https://doi.org/10.1542/peds.2007-3305
  65. Schmidt B, Davis P, Moddemann D, Ohlsson A, Roberts RS, Saigal S, et al. : Long-term effects of indomethacin prophylaxis in extremely-lowbirth-weight infants. N Engl J Med 344 : 1966-1972, 2001 https://doi.org/10.1056/NEJM200106283442602
  66. Sentilhes L, Senat MV, Ancel PY, Azria E, Benoist G, Blanc J, et al. : Prevention of spontaneous preterm birth: guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF). Eur J Obstet Gynecol Reprod Biol 210 : 217-224, 2017 https://doi.org/10.1016/j.ejogrb.2016.12.035
  67. Shah PS, Lui K, Sjors G, Mirea L, Reichman B, Adams M, et al. : Neonatal outcomes of very low birth weight and very preterm neonates: an international comparison. J Pediatr 177 : 144-152.e6, 2016 https://doi.org/10.1016/j.jpeds.2016.04.083
  68. Sheth RD : Trends in incidence and severity of intraventricular hemorrhage. J Child Neurol 13 : 261-264, 1998 https://doi.org/10.1177/088307389801300604
  69. Simons SH, van Dijk M, van Lingen RA, Roofthooft D, Duivenvoorden HJ, Jongeneel N, et al. : Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial. JAMA 290 : 2419-2427, 2003 https://doi.org/10.1001/jama.290.18.2419
  70. Skoll A, Boutin A, Bujold E, Burrows J, Crane J, Geary M, et al. : No. 364-antenatal corticosteroid therapy for improving neonatal outcomes. J Obstet Gynaecol Can 40 : 1219-1239, 2018 https://doi.org/10.1016/j.jogc.2018.04.018
  71. Society for Maternal-Fetal Medicine (SMFM), Reddy UM, Deshmukh U, Dude A, Harper L, Osmundson SS : Society for Maternal-Fetal Medicine Consult Series #58: use of antenatal corticosteroids for individuals at risk for late preterm delivery: replaces SMFM Statement #4, implementation of the use of antenatal corticosteroids in the late preterm birth period in women at risk for preterm delivery, August 2016. Am J Obstet Gynecol 225 : B36-B42, 2021 https://doi.org/10.1016/j.ajog.2021.07.023
  72. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. : Neonatal outcomes of extremely preterm infants from the NICHD neonatal research network. Pediatrics 126 : 443-456, 2010 https://doi.org/10.1542/peds.2009-2959
  73. Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Te Pas A, et al. : European consensus guidelines on the management of respiratory distress syndrome - 2019 update. Neonatology 115 : 432-450, 2019 https://doi.org/10.1159/000499361
  74. Takahashi T, Fee EL, Takahashi Y, Saito M, Yaegashi N, Usuda H, et al. : Betamethasone phosphate reduces the efficacy of antenatal steroid therapy and is associated with lower birthweights when administered to pregnant sheep in combination with betamethasone acetate. Am J Obstet Gynecol 226 : 564.e1-564.e14, 2022
  75. Toyoshima K, Kawataki M, Ohyama M, Shibasaki J, Yamaguchi N, Hoshino R, et al. : Tailor-made circulatory management based on the stress-velocity relationship in preterm infants. J Formos Med Assoc 112 : 510-517, 2013 https://doi.org/10.1016/j.jfma.2013.02.011
  76. van Alfen-van der Velden AA, Hopman JC, Klaessens JH, Feuth T, Sengers RC, Liem KD : Cerebral hemodynamics and oxygenation after serial CSF drainage in infants with PHVD. Brain Dev 29 : 623-629, 2007 https://doi.org/10.1016/j.braindev.2007.03.011
  77. Vargo L, Seri I : New NANN practice guideline: the management of hypotension in the very-low-birth-weight infant. Adv Neonatal Care 11 : 272-278, 2011 https://doi.org/10.1097/ANC.0b013e318229263c
  78. Vassilyadi M, Tataryn Z, Shamji MF, Ventureyra EC : Functional outcomes among premature infants with intraventricular hemorrhage. Pediatr Neurosurg 45 : 247-255, 2009 https://doi.org/10.1159/000228982
  79. Vesoulis ZA, Mathur AM : Cerebral autoregulation, brain injury, and the transitioning premature infant. Front Pediatr 5 : 64, 2017
  80. Volpe JJ : Brain injury in the premature infant. Neuropathology, clinical aspects, pathogenesis, and prevention. Clin Perinatol 24 : 567-587, 1997 https://doi.org/10.1016/S0095-5108(18)30159-3
  81. Volpe JJ : Edward B. Neuhauser lecture. Current concepts of brain injury in the premature infant. AJR Am J Roentgenol 153 : 243-251, 1989 https://doi.org/10.2214/ajr.153.2.243
  82. Volpe JJ : Intracranial Hemorrhage: Germinal Matrix-Intraventricular Hemorrhage of the Premature Infant in Volpe JJ (ed) : Neurology of the newborn, ed 4. Philadelphia : W.B. Saunders Company, 2001, pp428-493
  83. Wellons JC 3rd, Shannon CN, Holubkov R, Riva-Cambrin J, Kulkarni AV, Limbrick DD Jr, et al. : Shunting outcomes in posthemorrhagic hydrocephalus: results of a Hydrocephalus Clinical Research Network prospective cohort study. J Neurosurg Pediatr 20 : 19-29, 2017 https://doi.org/10.3171/2017.1.PEDS16496
  84. Whitelaw A, Jary S, Kmita G, Wroblewska J, Musialik-Swietlinska E, Mandera M, et al. : Randomized trial of drainage, irrigation and fibrinolytic therapy for premature infants with posthemorrhagic ventricular dilatation: developmental outcome at 2 years. Pediatrics 125 : e852-e858, 2010 https://doi.org/10.1542/peds.2009-1960
  85. Whitelaw A, Kennedy CR, Brion LP : Diuretic therapy for newborn infants with posthemorrhagic ventricular dilatation. Cochrane Database Syst Rev 2001 : CD002270, 2001
  86. Whitelaw A, Lee-Kelland R : Repeated lumbar or ventricular punctures in newborns with intraventricular haemorrhage. Cochrane Database Syst Rev 4 : CD000216, 2017
  87. WHO ACTION Trials Collaborators; Oladapo OT, Vogel JP, Piaggio G, Nguyen MH, Althabe F, et al. : Antenatal dexamethasone for early preterm birth in low-resource countries. N Engl J Med 383 : 2514-2525, 2020 https://doi.org/10.1056/NEJMoa2022398