Journal of the korean academy of Pediatric Dentistry (대한소아치과학회지)

Korean Academy of Pediatric Dentistry (대한소아치과학회)
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Assessment of Risk Factors for Dental Developmental Disorders in Pediatric Cancer Survivors

  • Jihyun Lee (Department of Pediatric Dentistry, College of Dentistry, Yonsei University) ;
  • Hyung-Jun Choi (Department of Pediatric Dentistry, College of Dentistry, Yonsei University) ;
  • Jaeho Lee (Department of Pediatric Dentistry, College of Dentistry, Yonsei University) ;
  • Je Seon Song (Department of Pediatric Dentistry, College of Dentistry, Yonsei University) ;
  • Chung-Min Kang (Department of Pediatric Dentistry, College of Dentistry, Yonsei University)
  • Received : 2023.07.24
  • Accepted : 2023.08.20
  • Published : 2023.11.30
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Abstract

This study was to examine the developmental dental abnormalities in childhood cancer survivors. Risk factors were assessed for 125 children with radiographic data through a retrospective analysis of medical records and panoramic images. 68.0% of childhood cancer survivors exhibited at least one dental abnormality. The types of abnormalities varied depending on the age at cancer diagnosis and treatment intensity, ranging from microdontia (43.2%), to abnormal root development (39.2%) and tooth agenesis (33.6%). Logistic regression analysis demonstrated that a young age at diagnosis (under 3 years), the use of heavy metal agents, a history of hematopoietic stem cell transplantation (HSCT), and combination treatment of chemotherapy, radiation therapy, and HSCT were associated with a significantly higher risk for overall dental abnormalities. The increased risk ratios were 6.00, 3.06, 3.22, and 7.87, respectively (p < 0.05). The results of this study will predict dental abnormality in permanent dentition according to the diagnosis age and treatment method of childhood cancer.

Keywords

Acknowledgement

This research was funded by the Yonsei University College of Dentistry Fund (6-2023-0014).

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