Journal of Applied Biological Chemistry

  • Volume 66
  • /
  • Pages.455-461
  • /
  • 2023
  • /
  • 1976-0442(pISSN)
  • /
  • 2234-7941(eISSN)
The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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The inhibitory effects of glabridin on human platelet aggregation and thrombus formation

  • Sang-Nam Park (Department of Clinical Laboratory Science, Kyungdong University) ;
  • Hyuk-Woo Kwon (Department of Biomedical Laboratory Science, Far East University)
  • Received : 2023.10.06
  • Accepted : 2023.10.31
  • Published : 2023.12.31
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Abstract

Glycyrrhiza glabra is a well-known medicinal herb that grows in various parts of the world and glabridin is a major chemical compound that is found in the root extract of Glycyrrhiza glabra. Glabridin is a natural compound known to have antioxidant, anti-inflammatory, anti-atherogenic, anti-osteoporotic and skin-whitening. In this study, we investigated if glabridin inhibited platelet aggregation and thrombus formation. We observed that glabridin inhibited collagen-induced platelet aggregation and suppressed signal transduction molecules such as phosphatidylinositol-3 kinase (PI3K), Akt, glycogen synthase kinase-3α/β (GSK-3α/β), SYK, cytosolic phospholipase A2, and p38 expression. In addition, glabridin suppressed thromboxane A2 generation and thrombin-induced clot retraction. Taken together, glabridin showed strong antiplatelet effects and may be used to block thrombosis- and platelet-mediated cardiovascular diseases.

Keywords

Acknowledgement

This work was supported by a 2022 Far East University Research Grant (FEU2022S04).

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