Acknowledgement
This work was supported by grants NRF-2021R1A4A1027355, NRF-2021R1A2C3011919, and NRF-2021R1C1C2009319 from the National Research Foundation of Korea (NRF).
References
- Bloodgood, R.A., Woodward, M.P., and Salomonsky, N.L. (1986). Redistribution and shedding of flagellar membrane glycoproteins visualized using an anti-carbohydrate monoclonal antibody and concanavalin A. J. Cell Biol. 102, 1797-1812. https://doi.org/10.1083/jcb.102.5.1797
- Bosch Grau, M., Masson, C., Gadadhar, S., Rocha, C., Tort, O., Marques Sousa, P., Vacher, S., Bieche, I., and Janke, C. (2017). Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration. J. Cell Sci. 130, 938-949. https://doi.org/10.1242/jcs.199091
- Garcia, G., Raleigh, D.R., and Reiter, J.F. (2018). How the ciliary membrane is organized inside-out to communicate outside-in. Curr. Biol. 28, R421-R434. https://doi.org/10.1016/j.cub.2018.03.010
- Hong, J.J., Kim, K.E., Park, S.Y., Bok, J., Seo, J.T., and Moon, S.J. (2021). Differential roles of tubby family proteins in ciliary formation and trafficking. Mol. Cells 44, 591-601. https://doi.org/10.14348/molcells.2021.0082
- Ishikawa, H. and Marshall, W.F. (2017). Intraflagellar transport and ciliary dynamics. Cold Spring Harb. Perspect. Biol. 9, a021998.
- Kanie, T., Abbott, K.L., Mooney, N.A., Plowey, E.D., Demeter, J., and Jackson, P.K. (2017). The CEP19-RABL2 GTPase complex binds IFT-B to initiate intraflagellar transport at the ciliary base. Dev. Cell 42, 22-36.e12. https://doi.org/10.1016/j.devcel.2017.05.016
- Lee, H., Noh, H., Mun, J., Gu, C., Sever, S., and Park, S. (2016). Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis. Nat. Commun. 7, 12799.
- Long, H. and Huang, K. (2020). Transport of ciliary membrane proteins. Front. Cell Dev. Biol. 7, 381.
- Maguire, J.E., Silva, M., Nguyen, K.C.Q., Hellen, E., Kern, A.D., Hall, D.H., and Barr, M.M. (2015). Myristoylated CIL-7 regulates ciliary extracellular vesicle biogenesis. Mol. Biol. Cell 26, 2823-2832. https://doi.org/10.1091/mbc.E15-01-0009
- Malicki, J. and Avidor-Reiss, T. (2014). From the cytoplasm into the cilium: bon voyage. Organogenesis 10, 138-157. https://doi.org/10.4161/org.29055
- Nabhan, J.F., Hu, R., Oh, R.S., Cohen, S.N., and Lu, Q. (2012). Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Proc. Natl. Acad. Sci. U. S. A. 109, 4146-4151. https://doi.org/10.1073/pnas.1200448109
- Nager, A.R., Goldstein, J.S., Herranz-Perez, V., Portran, D., Ye, F., Garcia-Verdugo, J.M., and Nachury, M.V. (2017). An actin network dispatches ciliary GPCRs into extracellular vesicles to modulate signaling. Cell 168, 252-263.e14. https://doi.org/10.1016/j.cell.2016.11.036
- Park, S., Lee, H., Lee, J., Park, E., and Park, S. (2019). Ependymal cells require Anks1a for their proper development. Mol. Cells 42, 245-251.
- Phua, S.C., Chiba, S., Suzuki, M., Su, E., Roberson, E.C., Pusapati, G.V., Setou, M., Rohatgi, R., Reiter, J.F., Ikegami, K., et al. (2017). Dynamic remodeling of membrane composition drives cell cycle through primary cilia excision. Cell 168, 264-279.e15. https://doi.org/10.1016/j.cell.2016.12.032
- Ryu, H., Lee, H., Lee, J., Noh, H., Shin, M., Kumar, V., Hong, S., Kim, J., and Park, S. (2021). The molecular dynamics of subdistal appendages in multi-ciliated cells. Nat. Commun. 12, 612.
- Shakya, S. and Westlake, C.J. (2021). Recent advances in understanding assembly of the primary cilium membrane. Fac. Rev. 10, 16.
- Taschner, M. and Lorentzen, E. (2016). The intraflagellar transport machinery. Cold Spring Harb. Perspect. Biol. 8, a028092.
- Wang, J., Nikonorova, I.A., Silva, M., Walsh, J.D., Tilton, P.E., Gu, A., Akella, J.S., and Barr, M.M. (2021). Sensory cilia act as a specialized venue for regulated extracellular vesicle biogenesis and signaling. Curr. Biol. 31, 3943-3951.e3. https://doi.org/10.1016/j.cub.2021.06.040
- Wang, J., Silva, M., Haas, L., Morsci, N., Nguyen, K.Q., Hall, D., and Barr, M. (2014). C. elegans ciliated sensory neurons release extracellular vesicles that function in animal communication. Curr. Biol. 24, 519-525. https://doi.org/10.1016/j.cub.2014.01.002
- Wood, C., Huang, K., Diener, D., and Rosenbaum, J. (2013). The cilium secretes bioactive ectosomes. Curr. Biol. 23, 906-911. https://doi.org/10.1016/j.cub.2013.04.019
- Wood, C.R. and Rosenbaum, J.L. (2015). Ciliary ectosomes: transmissions from the cell's antenna. Trends Cell Biol. 25, 276-285. https://doi.org/10.1016/j.tcb.2014.12.008