Acknowledgement
Bak SB would like to thank to the Ph.D.'s program of Dongguk University for completing the Ph.D. thesis through this work.
References
- Pan L, Li Z, Wang Y, Zhang B, Liu G, Liu J. Network pharmacology and metabolomics study on the intervention of traditional Chinese medicine Huanglian Decoction in rats with type 2 diabetes mellitus. J Ethnopharmacol. 2020;258:112842.
- Lee DH, Lee WY, Jung KW, et al. The inhibitory effect of cordycepin on the proliferation of MCF-7 breast cancer cells, and its mechanism: An investigation using network pharmacology-based analysis. Biomolecules. 2019;23(9):1-14. doi:10.3390/biom9090407
- Kim YW, Bak SB, Baek SY, et al. Mylabris phalerata induces the apoptosis and cell cycle delay in HCC, and potentiates the effect of sorafenib based on the molecular and network pharmacology approach. Mol Cell Toxicol. 2022:1-12.
- Lee W-Y, Lee C-Y, Lee J-S, Kim C-E. Identifying candidate flavonoids for non-alcoholic fatty liver disease by network-based strategy. Front Pharmacol. 2022:1718.
- Rui L. Energy metabolism in the liver. Compr Physiol. 2014;4(1):177.
- Cichoz-Lach H, Michalak A. Oxidative stress as a crucial factor in liver diseases. World J Gastroenterol WJG. 2014;20(25):8082.
- Lee J, Giordano S, Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J. 2012;441(2):523-540. https://doi.org/10.1042/BJ20111451
- Sham T-T, Yuen AC-Y, Ng Y-F, Chan C-O, Mok DK-W, Chan S-W. A review of the phytochemistry and pharmacological activities of raphani semen. Evidence-based Complement Altern Med. 2013;2013.
- Gao L, Li H, Li B, et al. Traditional uses, phytochemistry, transformation of ingredients and pharmacology of the dried seeds of Raphanus sativus L.(Raphani Semen), A comprehensive review. J Ethnopharmacol. 2022;294:115387.
- Lee JR, Shin JH, Byun SH, et al. Anti-obese and hypolipemic effects of the aqueous extracts of Raphani semen in mice fed high fat diet. J Korean Soc Appl Biol Chem. 2009;52:50-57. https://doi.org/10.3839/jksabc.2009.009
- Kim SK, Nam SJ, Jang H, Kim A, Lee JJ. TM-MC: A database of medicinal materials and chemical compounds in Northeast Asian traditional medicine. BMC Complement Altern Med. 2015;15(1):1-8. doi:10.1186/s12906-015-0758-5
- Huang Y, Fang J, Lu W, et al. A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling. Cell Chem Biol. 2019;26(8):1143-1158.e6. doi:10.1016/j.chembiol.2019.05.004
- Szklarczyk D, Santos A, Von Mering C, Jensen LJ, Bork P, Kuhn M. STITCH 5: Augmenting protein-chemical interaction networks with tissue and affinity data. Nucleic Acids Res. 2016;44(D1):D380-D384. doi:10.1093/nar/gkv1277
- Chen X, Ji ZL, Chen YZ. TTD: Therapeutic Target Database. Nucleic Acids Res. 2002;30(1):412-415. http://www.ncbi.nlm.nih.gov/pubmed/11752352%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC99057. https://doi.org/10.1093/nar/30.1.412
- Koopmans F, van Nierop P, Andres-Alonso M, et al. SynGO: an evidence-based, expert-curated knowledge base for the synapse. Neuron. 2019;103(2):217-234. https://doi.org/10.1016/j.neuron.2019.05.002
- Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003. doi:10.1101/gr.1239303
- Doncheva NT, Morris JH, Gorodkin J, Jensen LJ. Cytoscape StringApp: network analysis and visualization of proteomics data. J Proteome Res. 2018;18(2):623-632. https://doi.org/10.1021/acs.jproteome.8b00702
- Kuleshov M V., Jones MR, Rouillard AD, et al. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res. 2016. doi:10.1093/nar/gkw377
- Ahmad A, Ahmad R. Understanding the mechanism of hepatic fibrosis and potential therapeutic approaches. Saudi J Gastroenterol. 2012;18(3):155.
- Ha J, Lee S. Role of AMPK in the regulation of cellular energy metabolism. J Korean Endocr Soc. 2010;25(1):9-17. https://doi.org/10.3803/jkes.2010.25.1.9
- Gasparrini M, Giampieri F, M Alvarez Suarez J, et al. AMPK as a new attractive therapeutic target for disease prevention: the role of dietary compounds AMPK and disease prevention. Curr Drug Targets. 2016;17(8):865-889. https://doi.org/10.2174/1573399811666150615150235
- Alghamdi F, Alshuweishi Y, Salt IP. Regulation of nutrient uptake by AMP-activated protein kinase. Cell Signal. 2020;76:109807.
- STEIN SC, WOODS A, JONES NA, DAVISON MD, CARLING D. The regulation of AMP-activated protein kinase by phosphorylation. Biochem J. 2000;345(3):437-443. https://doi.org/10.1042/bj3450437
- Esquejo RM, Salatto CT, Delmore J, et al. Activation of liver AMPK with PF-06409577 corrects NAFLD and lowers cholesterol in rodent and primate preclinical models. EBioMedicine. 2018;31:122-132. https://doi.org/10.1016/j.ebiom.2018.04.009