DOI QR코드

DOI QR Code

Review of Antiphospholipid Antibody Positive Recurrent Abortion Treated with Herbal Medicine

항인지질항체 양성 습관성 유산의 한약 치료에 대한 무작위 대조군 임상 연구 분석

  • Ji-Youn, Song (Dept. of Korean Obstetrics & Gynecology, College of Korean Medicine, Daegu Haany University) ;
  • Dong-Chul, Kim (Dept. of Korean Obstetrics & Gynecology, College of Korean Medicine, Daegu Haany University)
  • 송지윤 (대구한의대학교 한의과대학 부인과학교실) ;
  • 김동철 (대구한의대학교 한의과대학 부인과학교실)
  • Received : 2022.12.28
  • Accepted : 2023.02.24
  • Published : 2023.02.24

Abstract

Objectives: This study was performed to analyze randomized controlled trial, which studied the effect of herbal medicine treatment on Antiphospholipid antibody positive recurrent abortion. Methods: We searched for randomized controlled trial of last 20 years based on Antiphospholipid antibody positive recurrent abortion and herbal medicine. The paper search was conducted through 7 online databases on July 16, 2022. Results: 9 studies were selected after selection and exclusion criteria. 5 studies compared combined treatment of herbal and western medicine, with western medicine alone. 4 studies compared herbal medicine alone with western medicine. Comparing with control group, the treatment group showed much improvement on conversion rate of anti-phospholipid antibodies, serum hCG and progesterone levels, pregnancy duration or fertility rates, and various symptoms. Conclusions: In this study, we found out benefit of herbal medicine with Antiphospholipid antibody positive recurrent abortion. For reliable evidence, further research is needed to establish safety of herbal medicines, standardize symptom criteria and specify the treatment course.

Keywords

References

  1. Ford HB, Schust DJ. Recurrent pregnancy loss: etiology, diagnosis, and therapy. Rev Obstet Gynecol. 2009;2(2):76-83.
  2. Macklon NS, Geraedts JP, Fauser BC. Conception to ongoing pregnancy: the 'black box' of early pregnancy loss. Hum Reprod Update. 2002;8(4):333-43. https://doi.org/10.1093/humupd/8.4.333
  3. Miyakis S, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295-306. https://doi.org/10.1111/j.1538-7836.2006.01753.x
  4. Lee JS, Hwang JJ, Shin SH. An Analysis of Patients with Antiphospholipid Antibody Syndrome in Korea. HIRA Big Data Breif. 2018;2(4):30-4.
  5. Yasuda M, et al. Prospective studies of the association between anticardiolipin antibody and outcome of pregnancy. Obstet Gynecol. 1995;86(4):555-9. https://doi.org/10.1016/S0029-7844(95)80015-8
  6. Korean Society of Obstetrics and Gynecology. Obstetrics. 6th edition. Seoul:Koonja publishing house. 2019:986.
  7. Barbour LA, et al. A prospective study of heparin-induced osteoporosis in pregnancy using bone densitometry. Am J Obstet Gynecol. 1994;170(3):862-9. https://doi.org/10.1016/s0002-9378(94)70299-3
  8. Zhang Y, et al. Low-dose aspirin use and recurrent gout attacks. Ann Rheum Dis. 2014;73(2):385-90. https://doi.org/10.1136/annrheumdis-2012-202589
  9. Jang JY. Complete Compendium of Zhang Jingyue(Jing yue quan shu) 2nd. Seoul: Daesung Munhwasa. 1988:26-40.
  10. Heuser C, et al. Idiopathic recurrent pregnancy loss recurs at similar gestational ages. Am J Obstet Gynecol. 2010;203(4):343-e1. https://doi.org/10.1016/j.ajog.2010.05.010
  11. Li C. Yi xue ru men(醫學入門). Seoul: Hansung Publishing Co. 1984:412-4.
  12. Kim KS, Kang MJ. Clinical Study On Oriental Treatment For Habitual Abortion. The Journal of Korean Obstetrics & Gynecology. 2000;13(2):452-67.
  13. Jung MY, Sohn YJ. A clinical case of habitual abortion. The Journal of Korean Obstetrics & Gynecology. 2005; 18(2):203-12.
  14. Cho HJ, Lim EM. Reccurent miscarriage overcome 14 case series. The Journal of Korean Obstetrics & Gynecology. 2005;18(2):159-68.
  15. Lee JE, et al. Obstetric Outcomes in 68 Pregnant Patients with Recurrent Pregnancy Loss on Oreintal Treatment and Analysis of Factors Affecting the Success of Birth. The Journal of Korean Obstetrics & Gynecology. 2010; 23(3):173-83. https://doi.org/10.15204/JKOBGY.2010.23.3.173
  16. Kim SH, Kim DI. Two Cases Report of Recurrent Miscarriage with Old Age and Underlying Diseases. The Journal of Korean Obstetrics & Gynecology. 2016;29(3):78-90. https://doi.org/10.15204/JKOBGY.2016.29.3.078
  17. Bae KR, et al. One Case of Pregnancy and Delivery in Habitual Abortion by Korean Traditional Medicine. The Journal of Korean Obstetrics & Gynecology. 2020;33(4):143-50. https://doi.org/10.15204/JKOBGY.2020.33.4.143
  18. Moon HJ, Lim EM. Systemic Review: The Study on Recurrent Miscarriage in PubMed. The Journal of Korean Obstetrics & Gynecology. 2004;17(2):78-91.
  19. Kim IJ, et al. A study on the latest trend of researches concerning recurrent pregnancy loss, and controlled experiment on animals about antiphospholipid antibody. The Journal of The Korea Institute of Oriental Medical Informatics. 2005;11(1):52-7.
  20. Qin T. Curative Effect Observation on the Treatment of Anticardiolipin Antibody Positive Recurrent Spontaneous Abortion by Tonifying Kidney and Nourishing Blood. Guangxi University of traditional Chinese Medicine. 2021.
  21. Huang HA. Effect of Jiaweidangguisan he shoutaiwan on Abnormal Antiphospholipid Antibody in Recurrent Abortion(加味当归散合寿胎丸治疗复发性流产抗磷脂抗体异常的疗效观察). Nei Mongol Journal of Traditional Chinese Medicine. 2021;40(2):38-40.
  22. Li GX. Effect of Jiaweidangguisan he shoutaiwan on Abnormal Antiphospholipid Antibody in Recurrent Abortion(加味当归散合寿胎丸治疗复发性流产抗磷脂抗体异常的疗效观察). Nei Mongol Journal of Traditional Chinese Medicine 2020;39(4):20-2.
  23. Xue WX. Analysis on Therapeutic Effect of Invigorated and Invigorated Qi on the Treatment of Recurrent Abortion of Lupus Coagulation Antibody. Qingdao University. 2017.
  24. Wang QQ. A intervention effect on bushentiaochongquyu fang combined with human chorionic gonadotropin and progestin for early recurrent spontaneous abortion patients caused by anti cardiolipin antibody positive. Henan University of Traditional Chinese Medicine. 2014.
  25. Yu Y, Li YH. Clinical Study on Treatment of Recurrent Abortion with Anti-phospholipid Antibody with Aspirin and Bushen Baochan tang(丙种球蛋白, 阿司匹林联合补肾保产汤治疗抗磷脂抗体阳性复发性流产的临床研究). Seek Medical and Ask the Medicine. 2013.
  26. Lei J. The Exploration of Treatment of The kidney and strengthening the spleen and removing blood stasis for ACA Positive RSA. yunnan University of TCM. 2012.
  27. Bao WW. The clinical study on treatment anticardiolipin antibodies positive of early recurrent abortion from nourishing kidney and promoting blood flow therapy of traditional medicine. Heilongjiang University of Traditional Chinese Medicine. 2011.
  28. Xuan HY. The clinical study on treatment anticardiolipin antibodies positive of early recurrent abortion from nourishing kidney and promoting blood flow therapy of traditional medicine hCG and dydrogesterone tablets. Heilongjiang University of Traditional Chinese Medicine. 2010.
  29. Bennett SM, et al. The scope and impact of perinatal loss: Current status and future directions. Professional Psychology: Research and Practice. 2005;36(2):180-7. https://doi.org/10.1037/0735-7028.36.2.180
  30. Adib-Rad H, et al. Psychological distress in women with recurrent spontaneous abortion: A case-control study. Turkish Journal of Obstetrics and Gynecology. 2019;16(3):151-7. https://doi.org/10.4274/tjod.galenos.2019.88899
  31. Andersen AMN, et al. Maternal age and fetal loss: population based register linkage study. BMJ. 2000;320(7251) :1708-12. https://doi.org/10.1136/bmj.320.7251.1708
  32. Rand JH, et al. Pregnancy loss in the antiphospholipid-antibody syndrome--a possible thrombogenic mechanism. N Engl J Med. 1997;337(3):154-60. https://doi.org/10.1056/NEJM199707173370303
  33. Di Simone N, et al. Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2- glycoprotein I. Arthritis Rheum. 2000; 43(1):140-50. https://doi.org/10.1002/1529-0131(200001)43:1<140::AID-ANR18>3.0.CO;2-P
  34. Habara T, et al. Elevated blood flow resistance in uterine arteries of women with unexplained recurrent pregnancy loss. Hum Reprod. 2002;17(1):190-4. https://doi.org/10.1093/humrep/17.1.190
  35. Koo BS, et al. Clinical Gynecologic Endocrinology. 2nd ed. Seoul:Korea Medical Book Publishing Company. 2001:139-54.
  36. Lee SH, et al. 滑胎(習慣性 流産)에 對한 原因別 治法 處方에 對한 文獻的考察. The Journal of Korean Academy of Medical Gi-gong. 1999;3(1):120-38.
  37. Park MS, Kim YM. Study on Clinical Diseases of Blood Stasis Pattern. Herbal Formula Science. 2013;21(1) :1-15. https://doi.org/10.14374/HFS.2013.21.1.001
  38. Yoo DY. 姙娠維持에 活用되는 金櫃當歸散料에 대한 硏究. The Journal of Korean Obstetrics & Gynecology. 1998;11(2):135-298.
  39. Choi JG, Yoo DY. A Study on Effect of Sutaehwan for treatment of Abortus habitualis. Journal of Haehwa Medicine. 2001;10(1):93-108.
  40. Ke J, Duan R. Effects of flavonoids from semen cuscutae on the hippocampal-hypothalamic-pituitary-ovarian sex hormone receptors in female rats exposed to psychological stress. Clin Exp Obstet Gynecol. 2013;40(2):271-4.
  41. Oh MS, et al. Study on Antioxidant Potency of Cuscutae Semen, Psoraleae Fructus, Cnidii Fructus and Epimedii Herba by DPPH Method. Herbal Formula Science. 2005;13(2):101-10.