Toxicological Research

  • 제39권1호
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  • Pages.169-177
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  • 2023
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지
DOI QR코드

DOI QR Code

Blood vessel remodeling in the cerebral cortex induced by binge alcohol intake in mice

  • Hiroshi, Hasegawa (Laboratory of Hygienic Sciences, Kobe Pharmaceutical University) ;
  • Toshiya, Tanaka (Laboratory of Hygienic Sciences, Kobe Pharmaceutical University) ;
  • Mari, Kondo (Laboratory of Hygienic Sciences, Kobe Pharmaceutical University) ;
  • Koji, Teramoto (Laboratory of Hygienic Sciences, Kobe Pharmaceutical University) ;
  • Kei, Nakayama (Laboratory of Hygienic Sciences, Kobe Pharmaceutical University) ;
  • Gi‑Wook, Hwang (Laboratory of Environmental and Health Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University)
  • 투고 : 2022.09.29
  • 심사 : 2022.12.05
  • 발행 : 2023.01.15
⟨ 이전 논문 다음 논문 ⟩

초록

Ethanol is toxic to the brain and causes various neurological disorders. Although ethanol can directly exert toxicity on neurons, it also acts on other cell types in the central nervous system. Blood vessel endothelial cells interact with, and are affected by blood ethanol. However, the effects of ethanol on the vascular structures of the brain have not been well documented. In this study, we examined the effects of binge levels of ethanol on brain vasculature. Immunostaining analysis indicated structural alterations of blood vessels in the cerebral cortex, which became more tortuous than those in the control mice after ethanol administration. The interaction between the blood vessels and astrocytes decreased, especially in the upper layers of the cerebral cortex. Messenger RNA expression analysis revealed a unique downregulation of Vegfa mRNA encoding vascular endothelial growth factor (VEGF)-A among VEGF, angiopoietin, endothelin family angiogenic and blood vessel remodeling factors. The expression of three proteoglycan core proteins, glypican-5, neurocan, and serglycin, was also altered after ethanol administration. Thus, binge levels of ethanol affect the expression of VEGF-A and blood vessel-supporting proteoglycans, resulting in changes in the vascular structure of the cerebral cortex.

키워드

과제정보

We would like to thank Ms. Tomoko Okuno, Laboratory of Hygienic Sciences, Kobe Pharmaceutical University, for her excellent technical assistance.

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