Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Surgery and Metronomic Chemotherapy in a Pet Rabbit (Oryctolagus cuniculus) with Mammary Gland Adenocarcinoma

  • Jihee Hong (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Jeong-Min Lee (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Ji-Young Lee (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Han-Joon Lee (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Dong-Kwan Lee (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Joong-Hyun Song (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Kun-Ho Song (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University)
  • Received : 2023.07.16
  • Accepted : 2023.11.07
  • Published : 2023.12.31
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Abstract

An 8-year-old female pet rabbit presented at the veterinary clinic for mammary gland palpation due to the presence of a mass. Upon physical examination, a mass was identified in the left fourth mammary gland. Abdominal ultrasonography revealed a 3 × 2 cm mass in the right uterus and general thickening of the endometrium, suggesting uterine sinusitis. Multiple pulmonary nodules suspected to be metastatic lesions were identified on chest radiography. Surgery was performed to mastectomy and ovariohysterectomy (OHE). The histopathological examination of the tumor revealed mammary gland adenocarcinoma (simple-type) with multiple nodules consisting of the proliferation of tumor cells forming tubules containing secretory materials, cellular debris, and solid nests with a central area of necrosis. Metronomic chemotherapy was performed with cyclophosphamide and lomustine (CCNU) based on the histopathological findings. The quality of life has been well maintained, with no specific clinical symptoms observed for 8 months after metronomic chemotherapy. To the best of authors' knowledge, this study is the first to examine the effects of metronomic chemotherapy with cyclophosphamide and lomustine in a pet rabbit.

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References

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