대한융합한의학회지 (Journal of Convergence Korean Medicine)

대한융합한의학회 (Academy of Convergence Korean Medicine)
권호 표지

난소 절제 및 고지방식이 투여로 유도된 갱년기 비만 쥐에서의 음양곽(淫羊藿)추출물의 효능 평가

Improvement of menopausal obesity by Schizandra chinensis extract obesity

  • 김미혜 (우석대학교 한의과대학)
  • Mi Hye Kim (College of Korean Medicine, Woosuk University)
  • 발행 : 2023.12.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: The purpose of this study was to investigate the ameliorative effects of the Epimedium koreanum Nakai (EK) on menopausal obesity in mice. Methods: To induce the menopausal obesity, female C57BL/6J mice were ovariectomized and fed with high fat diet for 12 weeks. 17β-estradiol was injected as a positive control and the extract of EK was orally administered 5 times per week for 6 weeks. Body weight, uterine weight and visceral fat weight were measured. The size of the adipocyte in visceral fat tissues was estimated by Hematoxylin and eosin staining. Fasting glucose level was estimated in serum. Results: Body weight and visceral fat weight were significantly decreased by EK treatment, while the uterine weight/body weight was increased in high fat diet-fed ovariectomized mice. The diameter of adipocyte in the visceral fat tissues was markedly reduced in EK-treated menopausal obese mice. In addition, the fasting blood glucose level was inhibited by oral EK administration. Conclusion: In conclusion, these results showed that EK has ameliorative effects on overweight after menopause. EK could be one of the alternative therapy for treating menopausal obesity.

키워드

참고문헌

  1. Davis SR, Castelo-Branco C, Chedraui P, Lumsden MA, Nappi RE, Shah D, Villaseca P. Understanding weight gain at menopause. Climacteric. 2012;15:419-429. https://doi.org/10.3109/13697137.2012.707385
  2. Toth MJ, Poehlman ET, Matthews DA, Tchernof A, MacCoss MJ. Effects of estradiol and progesterone on body composition, protein synthesis, and lipoprotein lipase in rats. Am. J. Physiol. Endocrinol. Metab. 2001;280:E496-E501. https://doi.org/10.1152/ajpendo.2001.280.3.E496
  3. Vrtacnik P, Ostanek B, Mencej-Bedrac S, Marc J. The many faces of estrogen signaling. Biochem. Med. (Zagreb). 2014;24:329-342. https://doi.org/10.11613/BM.2014.035
  4. Jelenik T, Roden M. How estrogens prevent from lipid-induced insulin resistance. Endocrinology. 2013;154:989-992. https://doi.org/10.1210/en.2013-1112
  5. Milewicz A, Tworowska U, Demissie M. Menopausal obesity - myth or fact?. Climacteric. 2001;4:273-283.
  6. Shin K, Lim S, Ahn S, Kim S, Park K. Difference in Components of Epimedium koreanum in Compliance with Seasons and Places of Collection. Korean J. Medicinal Crop Sci. 1996;4(4):321-328.
  7. Chun HJ, Mun YJ, Kim JH, Kim IK, Jeon BH, Woo WH. Effect of the aqueous extract of Epimedium Koreanum Nakai on melanin formation in B16 mouse melanoma cell line. 2000;44(5):455-462.
  8. Shin H, Yoo D. 加味歸脾湯으로 호전된 更年期 症候群 환자 치험 1례. 대전대학교 한의학연구소 논문집. 2011;20(1):105-110.
  9. Aljehani AA, Albadr NA, Eid BG, Abdel-Naim AB. Icariin enhances AMP-activated protein kinase and prevents high fructose and high salt-induced metabolic syndrome in rats. 2020;28(11):1309-1316.
  10. Qian H, Wu D, Li C, Liu X, Han X, Peng Y, Zhang H, Zhao B, Zhao Y. J. Ethnopharmacol. 2024;318:116957.
  11. Carr MC. The emergence of the metabolic syndrome with menopause. J. Clin. Endocrinol. Metab. 2003;88:2404-2411. https://doi.org/10.1210/jc.2003-030242
  12. Lee JE, Kim E, Kim MH, Hong J, Yang WM. Polygonatum stenophyllum improves menopausal obesity via regulation of lipolysis-related enzymes. J Nat Med. 2016;70(4):789-796. https://doi.org/10.1007/s11418-016-1018-9
  13. Netjasov AS, Vujovic S, Ivovic M, Tancic-Gajic M, Marina L, Barac M. Relationships between obesity, lipids and fasting glucose in the menopause. Srp Arh Celok Lek. 2013;141(1-2):41-47. https://doi.org/10.2298/SARH1302041S
  14. Van Hook J, Altman CE, Balistreri KS. Global patterns in overweight among children and mothers in less developed countries. Public Health Nutr. 2013;16:573-581. https://doi.org/10.1017/S1368980012001164
  15. Mauvais-Jarvis F, Clegg DJ, Hevener AL. The role of estrogens in control of energy balance and glucose homeostasis. Endocr Rev. 2013;34:309-338. https://doi.org/10.1210/er.2012-1055