The Journal of the Society of Stroke on Korean Medicine (대한중풍순환신경학회지)

The Society of Stroke on Korean Medicine (대한중풍순환신경학회)
권호 표지

A Case of Multiple System Atrophy(MSA-C) Patient with Autonomic Dysfunction Improved by Korean Medicine Treatment Including DokhwalJihwang-tang Gami-bang

독활지황탕가미방을 포함한 한의치료로 자율신경장애가 호전된 MSA-C 환자에 대한 치험 1례

  • Kyeong-Hwa Heo (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Dong-Joo Kim (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Hye-Min Heo (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Ye-Chae Hwang (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Seung-Yeon Cho (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Jung-Mi Park (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Chang-Nam Ko (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Seong-Uk Park (Department of Cardiology and Neurology of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 허경화 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 김동주 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 허혜민 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 황예채 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 조승연 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 박정미 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 고창남 (경희대학교 대학원 한방순환신경내과학교실) ;
  • 박성욱 (경희대학교 대학원 한방순환신경내과학교실)
  • Published : 2023.12.01
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Abstract

■Objectives This study is to report the effectiveness of Korean medicine on the treatment for multiple system atropy(MSA-C) patient complaining of autonomic dysfunction. ■Methods The patient was treated with Korean medicine(mainly DokhwalJihwang-tang Gami-bang) for 39 days. The evaluations were performed using UMSARS(Unified Multiple System Atrophy Rating Scale), SCOPA-AUT(The Scale for Outcomes in Parkinson's disease-Autonomic), K-OGS(Korean version of the Orthostatic Grading Scale). ■Results After treatment, the UMSARS score decreased from 25 to 18, the SCOPA-AUT score decreased from 21 to 14, K-OGS score decrease from 15 to 8. ■Conclusion This case suggests that Korean medicine treatment may be effective for MSA-C patients with autonomic dysfuction.

Keywords

References

  1. Fanciulli A, Wenning GK. Multiple-system atrophy. New England Journal of Medicine. 2015;372(3):249-63.  https://doi.org/10.1056/NEJMra1311488
  2. Gilman S, Wenning G, Low Pa, Brooks D, et al. Second consensus statement on the diagnosis of multiple system atrophy. Neurology. 2008;71(9):670-6.  https://doi.org/10.1212/01.wnl.0000324625.00404.15
  3. Wenning GK, Geser F, Krismer F, et al. The natural history of multiple system atrophy: a prospective European cohort study. The lancet neurology. 2013;12(3):264-74.  https://doi.org/10.1016/S1474-4422(12)70327-7
  4. Low PA, Reich SG, Jankovic J, et al. Natural history of multiple system atrophy in the USA: a prospective cohort study. The Lancet Neurology. 2015;14(7):710-9.  https://doi.org/10.1016/S1474-4422(15)00058-7
  5. Schrag A, Ben SY, Quinn, N. Prevalence of progressive supranuclear palsy and multiple system atrophy: a cross-sectional study. Lancet 1999. 354(9192):1771-5.  https://doi.org/10.1016/S0140-6736(99)04137-9
  6. Flabeau O, Meissner WG, Tison F. Multiple system atrophy: current and future approaches to management. The rapeutic advances in neurological disorders 2010. 3(4):249-63.  https://doi.org/10.1177/1756285610375328
  7. Seong-Uk Park. The essence of pharmacoacupuncture: Seoul: wooripub. 2020:1-2, 13-21, 57-82 
  8. Wenning GK, Tison F, Seppi K, et al. Development and validation of the unified multiple system atrophy rating scale (UMSARS). Movement Disorders. 2004;19(12):1391-402  https://doi.org/10.1002/mds.20255
  9. Visser M, Marinus J, Stiggelbout AM, et al. Assessment of autonomic dysfunction in Parkinson's disease: the SCOPA-AUT. Movement disorders: official journal of the Movement Disorder Society. 2004;19(11):1306-12.  https://doi.org/10.1002/mds.20153
  10. Schrezenmaier C, Gehrking JA, Hines SM, et al. Evaluation of orthostatic hypotension: relationship of a new self-report instrument to laboratory-based measures. Mayo Clinic Proceedings; 2005: Elsevier. 2005;80(30):330-334  https://doi.org/10.4065/80.3.330
  11. Gliman S., Low PA., Quinn N., et al. Consensus statement on the diagnosis of multiple system atrophy. Clin Auton Res. 1999. 8:359-62 
  12. Ashton Powell, et. al. Spinocerebellar Ataxia: Patient and Health Professional Perspectives on Whether and How Patents Affect Access to Clinical Genetic Testing. Genet Med. 2010;12: 83-110  https://doi.org/10.1097/GIM.0b013e3181d67e44
  13. Roy S, Srivastava AK, Jaryal AK, et al. Cardiovascular responses during cold pressor test are different in Parkinson disease and multiple system atrophy with parkinsonism. Clin Auton Res 2015;25:219-24.  https://doi.org/10.1007/s10286-015-0294-x
  14. Stocchi F, Carbone A, Inghilleri M, et al. Urodynamic and neurophysiological evaluation in Parkinson's disease and multiple system atrophy. J Neurol Neurosurg Psychiatry 1997;62:507-11  https://doi.org/10.1136/jnnp.62.5.507
  15. Sakakibara R, Hattori T, Uchiyama T, et al. Videourodynamic and sphincter motor unit potential analyses in Parkinson's disease and multiple system atrophy. J Neurol Neurosurg Psychiatry 2001;71:600-6.  https://doi.org/10.1136/jnnp.71.5.600
  16. Lipp A, Sandroni P, Ahlskog JE, et al. Prospective differentiation of multiple system atrophy from Parkinson disease, with and without autonomic failure. Arch Neurol 2009;66:742-50  https://doi.org/10.1001/archneurol.2009.71
  17. Geser F, Wenning GK, Seppi K, et al. Progression of multiple system atrophy (MSA): A prospective natural history study by the European MSA Study Group (EMSA SG). Mov Disord. 2006;21:179-86.19.  https://doi.org/10.1002/mds.20678
  18. Lee SY, Koh BH, Lee EJ, et al. Systematic review on researches of Sasang Constitution Diagnosis using facial feature. J Sasang Constit Med. 2012;24(4):17-27.  https://doi.org/10.7730/JSCM.2012.24.4.17
  19. Huh MH, Koh BH, Song IB. The body measuring method to classify sasang constitutions. J. of Sasang Const. Med. 2002; 14(1) 
  20. Kim KT, Eom HS, Lee IS, et al. Study on standard symptoms and gender differences of QiXueYinYang asthenia syndromes based on questionnaire analysis. Korean J Orient Physiol & Pathol. 2006;20(6):1742-8 
  21. Lee JH, Lee EJ. Clinical Practice Guideline for Soyangin Disease of Sasang Constitutional Medicine: Diagnosis and Algorithm. J Sasang Constitut Med 2014; 26(3), 224-240  https://doi.org/10.7730/JSCM.2014.26.3.224
  22. Ahn TW, Lee SY. Effects of Hyeongbangpaedok-san and Dokhwaljihwang-tang that Get Weight, Hematology, Biochemistry Change by Wistar rat's aging. J. of Sasang Constitutional Medicine. 2005;17(3):91-102. 
  23. Wui YL. Se-euideukhyobang. 3rd edition. Shanghai in China:Shanghai Scientific & Technical Publishers. 1997:307 
  24. Sakong JW, Kim DH, Ha JW, et al. Herbal Medicine (Cheonwangbosim-Dan, Tianwangbuxin- Pellet) for Insomnia Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J of Oriental Neuropsychiatry. 2018;29(4), 267-280. 
  25. Krismer F, et al.,Minimally clinically important decline in the parkinsonian variant of multiple system atrophy.Movement Disorders 2016;31(10):1577-81  https://doi.org/10.1002/mds.26743
  26. Yim TB, et al. A Case of Korean Medical Treatment on Multiple System Atrophy with Gait Disturbance, J.Int.KoreanMed. 2020;41(5):821-829  https://doi.org/10.22246/jikm.2020.41.5.821
  27. Hwang YC, et al. A Case of Korean Medical Treatment on Advanced-Stage Multiple System Atrophy with Gait Disturbance, J of the Society of Stroke on KoreanMed 2021; 22(1):31-44 
  28. Shin BC, Song YS, Kin DH, et al. Influence on Vertebral Artery and Basilar Artery Blood flow by Cervical CHUNA Manual Therapy. The Journal of Korea CHUNA Manual Medicine for Spine& Nerves 2000;1(1):45-53. 
  29. Ku JS, Jung C, Hwang JH. Toxicological study of su-eohyeol pharmacopuncture in an in vivo micronucleus test in sprague-dawley rats. Korean J Acupunct. 2022;39(2). 54-62. https://doi.org/10.14406/acu.2022.008