한국동물위생학회지 (Korean Journal of Veterinary Service)

  • 제46권4호
  • /
  • Pages.263-268
  • /
  • 2023
  • /
  • 3022-7372(pISSN)
  • /
  • 2287-7630(eISSN)
한국동물위생학회 (The Korean Society of Veterinary Service)
권호 표지
DOI QR코드

DOI QR Code

Evaluation of concurrent immunizations with equine influenza virus and strangles vaccines

  • Dong-Ha Lee (Racing Resources Management Team, Jeju, Korea Racing Authority) ;
  • Kyungmin Jang (Racing Resources Management Team, Jeju, Korea Racing Authority) ;
  • Taemook Park (Racing Resources Management Team, Jeju, Korea Racing Authority) ;
  • Youngjong Kim (Racing Resources Management Team, Jeju, Korea Racing Authority) ;
  • Kyoung Hwan Kim (Racing Resources Management Team, Jeju, Korea Racing Authority) ;
  • Eun-bee Lee (Department of Veterinary Medicine, College of Veterinary Medicine, Jeju National University) ;
  • Young Beom Kwak (Racing laboratory, Jeju, Korea Racing Authority) ;
  • Eun-Ju Ko (Department of Veterinary Medicine, College of Veterinary Medicine, Jeju National University)
  • 투고 : 2023.11.12
  • 심사 : 2023.12.07
  • 발행 : 2023.12.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Despite regular vaccinations, equine influenza virus (EIV) and Streptococcus equi subsp. equi (strangles) are the cause of highly contagious respiratory infections in horses. Many recent studies have reported that the concurrent administration of two vaccines could simplify horse management and minimize veterinary expenses. However, there is little information available regarding the efficacy of concurrent vaccinations against EIV and strangles. In this study, we evaluated EIV-specific antibody responses following the single EIV vaccination with the recombinant viral-vectored EIV vaccine or concurrent vaccination with the EIV and inactivated strangles vaccines. Blood samples were collected at 1-, 2-, 4-, and 8 weeks post-immunization (wpi) from each group. EIV-specific antibodies were evaluated by enzyme-linked immunosorbent assay (ELISA) and hemagglutination inhibition (HAI) assay. Both single and concurrent vaccination showed similar levels of EIV-specific serum immunoglobulin g (IgG) at 1 and 2 wpi. However, at 4 to 8 wpi, the EIV-only vaccination group showed significantly higher serum IgG levels than those from the concurrently vaccinated group. The HAI titers showed similar trends as the ELISA data, except at 8 wpi when both groups presented HAI titers with no significant differences. These data demonstrate that the concurrent vaccination against EIV and strangles could compromise the humoral immune response to equine influenza between vaccination intervals, which suggests the use of the consecutive vaccination protocol for EIV and strangles rather than concurrent vaccination.

키워드

참고문헌

  1. Allkofer A, Garvey M, Ryan E, Lyons R, Ryan M, Lukaseviciute G, Walsh C, Venner M, Cullinane A. 2021. Primary vaccination in foals: a comparison of the serological response to equine influenza and equine herpesvirus vaccines administered concurrently or 2 weeks apart. Arch Virol 166: 571-579. https://doi.org/10.1007/s00705-020-04846-6
  2. Bryant NA, Paillot R, Rash AS, Medcalf E, Montesso F, Ross J, Watson J, Jeggo M, Lewis NS, Newton JR. 2010. Comparison of two modern vaccines and previous influenza infection against challenge with an equine influenza virus from the Australian 2007 outbreak. Vet Res 41.
  3. Cho MS, Lee JY, Lee SK, Song JY, Lee J, Hyun BH, Cho SD, Ouh IO. 2020. Antibody responses after vaccination against equine influenza virus in the Republic of Korea in 2019. J Prev Vet Med 44: 132-135. https://doi.org/10.13041/jpvm.2020.44.3.132
  4. El-Hage C, Hartley C, Savage C, Watson J, Gilkerson J, Paillot R. 2022. Assessment of humoral and long-term cell-mediated immune responses to recombinant canarypox-vectored equine influenza virus vaccination in horses using conventional and accelerated regimens respectively. Vaccines 10: 855.
  5. Gildea S, Quinlivan M, Murphy BA, Cullinane A. 2013. Humoral response and antiviral cytokine expression following vaccination of thoroughbred weanlings-A blinded comparison of commercially available vaccines. Vaccine 31: 5216-5222. https://doi.org/10.1016/j.vaccine.2013.08.083
  6. Gildea S, Sanchez Higgins MJ, Johnson G, Walsh C, Cullinane A. 2016. Concurrent vaccination against equine influenza and equine herpesvirus-a practical approach. Influenza Other Respir Viruses 10: 433-437. https://doi.org/10.1111/irv.12396
  7. Lee DH, Birhanu BT, Lee EB, Lee SJ, Boby N, Park YS, Park SC. 2020. Pharmacokinetic and pharmacodynamic integration for optimal dosage of cefquinome against Streptococcus equi subsp. equi in foals. Vet Res 51:1-12. https://doi.org/10.1186/s13567-020-00853-2
  8. Lee DH, Lee Eb, Seo Jp, Ko EJ. 2022. Evaluation of concurrent vaccinations with recombinant canarypox equine influenza virus and inactivated equine herpesvirus vaccines. J Anim Sci Biotechnol 64: 588.
  9. Ohta M, Bannai H, Nemoto M, Kambayashi Y, Tamura N, Tsujimura K. 2020. Antibody responses against equine influenza virus induced by concurrent and by consecutive use of an inactivated equine influenza virus vaccine and a modified live equine herpesvirus type 1 vaccine in thoroughbred racehorses. J Equine Vet Sci 94: 103221.
  10. Paillot R. 2014. A systematic review of recent advances in equine influenza vaccination. Vaccines 2: 797-831. https://doi.org/10.3390/vaccines2040797
  11. Pavulraj S, Bergmann T, Trombetta CM, Marchi S, Montomoli E, Alami SSE, Ragni-Alunni R, Osterrieder N, Azab W. 2021. Immunogenicity of Calvenza-03 EIV/EHV® vaccine in horses: comparative in vivo study. Vaccines 9: 166.