Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
권호 표지
DOI QR코드

DOI QR Code

Current Research Trends of Traditional Herbal Medicine for Alcohol Use Disorder

알코올 사용장애의 한약치료 연구동향

  • So-Hyeon Park (Department of Neuropsychiatry, School of Korean Medicine, Pusan National University) ;
  • Jun-Hee Cho (Department of Neuropsychiatry, School of Korean Medicine, Pusan National University) ;
  • Bo-kyung Kim (Department of Neuropsychiatry, School of Korean Medicine, Pusan National University) ;
  • Jung-Hwa Lim (Department of Neuropsychiatry, Pusan National University Korean Medicine Hospital)
  • 박소현 (부산대학교 한의학전문대학원 한방신경정신과) ;
  • 조준희 (부산대학교 한의학전문대학원 한방신경정신과) ;
  • 김보경 (부산대학교 한의학전문대학원 한방신경정신과) ;
  • 임정화 (부산대학교 한방병원 한방신경정신과)
  • Received : 2023.11.24
  • Accepted : 2023.12.16
  • Published : 2023.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: To review clinical research trends of herbal medicine treatment for alcohol use disorder. Methods: Three domestic databases and eight foreign databases were used to search for published articles by November 1, 2023 in each database. A total of 9 studies were included. Results: There were eight randomized control studies and one non-randomized control study. All randomized control studies were designed with 2-arm paralleled. The non-randomized control study was designed with 2-arm crossover. The most commonly used prescriptions were Kudzu extract capsules and Seoganhaeul capsules. The most used herbs were Puerariae Radix, Hyperici Perforati Herba, and Acanthopanacis Senticosi Radix et Rhizoma seu Caulis. Conclusions: Traditional herbal medicine might be effective in alleviating drinking behavior, physical problems, and psychological problems of patients with alcohol use disorder. However, the limited number of included studies suggests that further methodologically rigorous research studies on herbal medicine treatment for alcohol use disorder are needed in the future.

Keywords

Acknowledgement

This work was supported by clinical research grant from Pusan National University Hospital in 2023.

References

  1. American Psychiatric Association. Diagnosticand statistical manual of mental disorders: DSM-5. Washington, DC: American Psychiatric Association; 2013:537-51.
  2. Rehm J, Shield KD. Global Burden of Disease and the Impact of Mental and Addictive Disorders. Curr Psychiatry Rep. 2019;21:10.
  3. Vladimir P, Dag R. Global status report on alcohol and health 2018. World health organization. 2018.
  4. Korean Ministry of Health and Welfare. The epidemiological survey of mental disorders in Korea 2021. Sejong;Korean Ministry of Health and Welfare:2021.
  5. American Psychiatric Association. Diagnosticand statistical manual of mental disorders Text Revision: DSM-5-TR. Washington, DC: American Psychiatric Association; 2022:613.
  6. Kim JS, Jun JH. The recovery experience of male alcoholics based on a life history study. Studies on life and culture. 2019;52:201-23.
  7. Cho YH, Lee EY, Her ES, Hwang GB, Lim KY, Noh JS, et.al. Association Between Suicide Risk and Comorbidity of Mood Disorder and Alcohol Use Disorder:Using Common Data Model in Psychiatry. J Korean Neuropsychiatr Assoc. 2021;60:232-9. https://doi.org/10.4306/jknpa.2021.60.3.232
  8. Beigel A, Hunter EJ, Tamerin JS, Chapin EH, Lowery MJ. Planning for the development of comprehensive community alcoholism services: I. The prevalence survey. Am J Psychiatry. 1974;131:1112-6.
  9. Mullahy J, Sindelar J. Employment, unemployment, and problem drinking. Journal of Health Economics. 1996:(15):409-34.
  10. Min SG. The latest psychiatry, 6th edition. Seoul:Ilzogak; 2015:543-54.
  11. Joe KH. Treatment of the Alcohol Use Disorder at Outpatient Psychiatric Clinic. J Korean Neuropsychiatr Assoc. 2019;58:159-66. https://doi.org/10.4306/jknpa.2019.58.3.159
  12. Lee GS. Treatment of Alcohol Use Disorder. The Journal of Korean Diabetes. 2012;13:85-90. https://doi.org/10.4093/jkd.2012.13.2.85
  13. Korean Academy of Addiction Psychiatry, Addiction Psychiatry, 2019;196-200.
  14. Mekonen T, Chan GCK, Conner J, Hall W, Hides L, Leung J. Treatment rates for alcohol use disorders: a systematic review and meta-analysis. Addiction. 2021;116:2617-34. https://doi.org/10.1111/add.15357
  15. Cho MJ, Ham BJ, Kim CG, Park KG, Jeong EG, Seo DW, et al. Korean Epidemiologic Catchment Area(KECA) Study for Psychiatric Disorders : Prevalence of Specific Psychiatric Disorders. 2004;43:470-80.
  16. The Textbook Compilation Committee of Neuropsychiatry of Korean Medical Schools in Nation. 2018 Korean society of oriental neuropsychiatry. Seoul:Maver. 2018:338-9.
  17. Chen P, Li J, Han X, Grech D, Xiong M, Bekker A, Ye JH. Acupuncture for alcohol use disorder. Int J Physiol Pathophysiol Pharmacol. 2018;10:60-9.
  18. Shin NY, Lim YJ, Yang CH, Kim C. Acupuncture for Alcohol Use Disorder: A Meta-Analysis. Evid Based Complement Alternat Med. 2017. https://doi.org/10.1155/2017/7823278
  19. Chen H, Feng J, Chen L, Huang J, Zhang P, Chen C, Lu L, Tang C. Acupoint stimulation for alcohol use disorder: A systematic review and meta-analysis. Medicine (Baltimore). 2023;102:e32614.
  20. Park JH, Pyeon SH. Clinical Review of Alcoholism Treatment Using Auricular acupuncture and Traditional herbal medication. The Journal of East-west medicines. 1996;21:1-15.
  21. Yang FJ, He JZ, Xiu MH, Liu YQ. Research progress of traditional Chinese medicine on alcohol dependence treatment. Chinese Journal of Drug Dependence. 2021;30:332-7.
  22. Shebek J, Rindone JP. A pilot study exploring the effect of Kudzu root on the drinking habits of patients with chronic alcoholism. The journal of alternative and complementary medicine. 2000;6:45-8. https://doi.org/10.1089/acm.2000.6.45
  23. Lukas SE, Penetar D, Berko J, Vicens L, Palmer C, Mallya G. An extract of the Chinese herbal root Kudzu reduces alcohol drinking by heavy drinkers in a naturalistic setting. Alcoholism:clinical and experimental research. 29:756-62.
  24. Cao GY, Zhang LY, Zhang GQ, Zhou HS, Deng CJ. A Comparative study on the treatment of alcohol dependence by traditional Chinese medicine Jiedu decoction and furazolidone. Herbi medical J. 2007;28:1196-7.
  25. Chang JH, Sun GC. Application of Hugan Capsule in Alcohol Dependence Patients. Chinese Community Doctors. 2011;35(13):85.
  26. Lukas SE, Penetar D, Su ZH, Geaghan T, Maywalt M, Tracy M, et. al. A Standardized Kudzu Extract (NPI-031) Reduces Alcohol Consumption in Non Treatment-Seeking Male Heavy Drinkers. Psychopharmacology. 2013;226:65-73. https://doi.org/10.1007/s00213-012-2884-9
  27. Wang ZB, Li JX, Han HX, Yu YQ. Influence of modified Chaihu Plus Longgu Muli Tang on quality of life in patients with alcohol dependence. Modern Chinese Clinical Medicine. 2014;21:33-5.
  28. Yin XF, Chen J, Xia QC, Qin B, Hu SJ, Wang YH. Comparison between Shugan Jieyu Capsule and Diazepam Tablets in Treatment of Alcohol Dependence Syndrome with Anxiety. Chinese Journal of Rural Medicine and Pharmacy. 2019;26:37-8.
  29. Liu H. Effect of Shugan Jieyu Capsule on Alcohol Dependence Depression and Anxiety Symptoms. Chinese journal of clinical rational drug use. 2020;13:100-1.
  30. Qin JF, Lu W, Chen LY. Curative effect of Shugan Jieyu Capsules combined with family therapy on alcohol dependence syndrome. Journal of hubei of Chinese medicine. 2023;25:107-9.
  31. The Textbook Compilation Committee of herbal medicine of Korean Medical Schools in Nation. Herbal medicine. Seoul:Younglimsa. 2020:184, 186.
  32. Wang S, Zhang S, Wang S, Gao P, Dai L. A comprehensive review on Pueraria: Insights on its chemistry and medicinal value. Biomed Pharmacother. 2020;131:Article 110734.
  33. Keung WM, Vallee BL. Kudzu root: an ancient Chinese source of modern antidipsotropic agents. Phytochemistry. 1998;47:499-506. https://doi.org/10.1016/S0031-9422(97)00723-1
  34. Keung WM. Biogenic aldehyde (s) derived from the action of monoamine oxidase may mediate the antidipsotropic effect of daidzin. Chemico-biological interactions. 2001;130:919-30. https://doi.org/10.1016/S0009-2797(00)00245-3
  35. Zhou YX, Zhang H, Peng C. Puerarin: a review of pharmacological effects. Phytother Res. 2014;28:961-75. https://doi.org/10.1002/ptr.5083
  36. Benlhabib E, Baker JI, Keyler DE, Singh AK. Kudzu root extract suppresses voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. J Med Food. 2004;7:168-79. https://doi.org/10.1089/1096620041224210
  37. Peng JH, Cui T, Huang F, Chen L, Zhao Y, Xu L, et al. Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. J Pharmacol Exp Ther. 2013;344:646-54. https://doi.org/10.1124/jpet.112.201137
  38. Bian H, Wu Y, Cui Z, Zheng H, Li Y, Zou D. Study on the autophagy-related mechanism of puerarin in improving the cognitive impairment induced by alcohol in female mice. Brain Inj. 2022;36:137-45. https://doi.org/10.1080/02699052.2022.2037712
  39. Kim BH. The Protective Effects of Pueraria Radix against Chronic Alcohol-induced Muscle Atrophy in Rats. J Korean Med Rehabil. 2017;27:1-8. https://doi.org/10.18325/jkmr.2017.27.2.1
  40. Song SG, Lee MJ. The effects of Galwhahaejung-tang administration and physical exercise on chronic alcoholic absorption of white mice: changes of the CYP2E1 in the hepatic microsome and transaminases GOT,GPT. Journal of oriental rehabilitation medicine. 2001;11:205.
  41. Ministry of food and drug safety. Publication of English Version of National Standard of Traditional Medicinal (Herbal and Botanical) Materials. Seoul:biohub. 2013.
  42. Ministry of food and drug safety. Korean Pharmacopoeia. 2023.11.24. https://nedrug.mfds.go.kr/pbp/CCEKP14/selectList
  43. Chinese pharmacopoeia commission. Pharmacopoeia of the People's Republic of China. China:Beijing. 2015.
  44. Le TT, McGrath SR, Fasinu PS. Herb-drug Interactions in Neuropsychiatric Pharmacotherapy - A Review of Clinically Relevant Findings. Curr Neuropharmacol. 2022 Aug 3;20:1736-51. https://doi.org/10.2174/1570159X19666210809100357
  45. Rezvani AH, Overstreet DH, Yang Y, Clark E Jr. Attenuation of alcohol intake by extract of Hypericum perforatum (St. John's Wort) in two different strains of alcohol-preferring rats. Alcohol Alcohol. 1999;34:699-705. https://doi.org/10.1093/alcalc/34.5.699
  46. Choi SH, Yang JH, Gu SG, Han CH. Methanolic extract from the root of Bupleuri falcatum L. attenuates co-caine-induced c-Fos expression in rat brain. Korea institute of oriental medicine. 2010;16:141-7.
  47. Yoon SS, Kim HS, Cho HY, Yun J, Chung EY, Jang CG, Kim KJ, Yang CH. Effect of saikosaponin A on maintenance of intravenous morphine self-administration. Neurosci Lett. 2012;529:97-101. https://doi.org/10.1016/j.neulet.2012.08.075
  48. Yoon SS, Seo JW, Ann SH, Kim HY, Kim HS, Cho HY, Yun J, Chung EY, Koo JS, Yang CH. Effects of saikosaponin A on cocaine self-administration in rats. Neurosci Lett. 2013;555:198-202. https://doi.org/10.1016/j.neulet.2013.09.029
  49. Deng XX, Chen XH, Cheng WM, Shen ZD, Bi KS. Simultaneous LC-MS Quantification of 15 Lignans in Schisandra chinensis (Turcz.) Baill. Fruit. Chromatographia. 2008;67:559-66. https://doi.org/10.1365/s10337-008-0589-3
  50. Han CK, Seong KS, Lee KW, Pa가 SS, Jeong JY, Kim SS. Effects of Omija Concentrate on Blood Alcohol Clearance and Hepatoprotective Function in Rats Induced by Acute Ethanol Intoxication and Chronic Ethanol Treatment. J Korean Soc Food Sci Nutr. 2014;43:1139-47. https://doi.org/10.3746/jkfn.2014.43.8.1139
  51. Selzer ML. The Michigan alcoholism screening test: the quest for a new diagnostic instrument. Am J Psychiatry. 1971;127:1653-8. https://doi.org/10.1176/ajp.127.12.1653
  52. Kim KB, Hahn KS, Lee JK, Rhee MK, Kim YK, Kim CK. The preliminary study of the Korean alcoholism screening test (III). J Korean Neuropsychiatr Assoc. 1991;30:569-81.
  53. Mayfield D, McLeod G, Hall P. The CAGE questionnaire: validation of a new alcoholism screening instrument. Am J Psychiatry. 1974;131:1121-3. https://doi.org/10.1176/ajp.131.10.1121
  54. Cherpitel CJ. A brief screening instrument for problem drinking in the emergency room: the RAPS4. Rapid Alcohol Problems Screen. J Stud Alcohol. 2000;61:447-9. https://doi.org/10.15288/jsa.2000.61.447
  55. Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M. Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption-II. Addiction. 1993;88:791-804. https://doi.org/10.1111/j.1360-0443.1993.tb02093.x