Journal of Mushroom (한국버섯학회지)

The Korean Society of Mushroom Science (한국버섯학회)
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Anti-inflammatory effect of ganodermanondiol from Ganoderma lucidumon RAW 264.7 cells

영지 유래 가노더마논디올의 RAW 264.7 세포주에 대한 항염 효과

  • Che-Hwon Park (Department of Medicinal Biosciences, College of Biomedical and Health Science, Konkuk University) ;
  • Ju-Hyeon Shin (Department of Medicinal Biosciences, College of Biomedical and Health Science, Konkuk University) ;
  • Young-Jin Park (Department of Medicinal Biosciences, College of Biomedical and Health Science, Konkuk University)
  • 박채훤 (건국대학교 의료생명대학 바이오의약학과) ;
  • 신주현 (건국대학교 의료생명대학 바이오의약학과) ;
  • 박영진 (건국대학교 의료생명대학 바이오의약학과)
  • Received : 2023.10.24
  • Accepted : 2023.11.27
  • Published : 2023.12.31
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Abstract

Owing to its diverse range of bioactive compounds, Ganoderma lucidumhas garnered significant research attention for health promotion and disease prevention. Ganodermanondiol, which has a triterpenoid structure, is one of the major active compounds of G. lucidum. In the present study, the anti-inflammatory effects of ganodermanondiol were investigated to evaluate its usefulness as a functional ingredient. Ganodermanondiol (0.5-2 ㎍/mL) significantly inhibited the production of nitric oxide (NO), the expression of the cytokines tumor necrosis factor (TNF)??and interleukin 6 (IL-6), and the expression of cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) in lipopolysaccharide-induced RAW 264.7 (murine macrophage) cells. Ganodermanondiol (0.5-2 ㎍/mL) also inhibited the phosphorylation of mitogen-activated protein kinase (MAPK) signal molecules, including p38 and c-Jun N-terminal protein kinase (JNK) in RAW 264.7 cells. Ganodermanondiol significantly inhibited the essential factors involved in the inflammatory responses of RAW 264.7 cells and would, therefore, serve as a potential prophylactic and therapeutic agent for immune-related diseases.

Keywords

Acknowledgement

이 논문은 2022년도 건국대학교 KU학술연구비 지원에 의한 결과임

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