대한본초학회지 (The Korea Journal of Herbology)

  • 제37권6호
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  • Pages.29-36
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  • 2022
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지
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수종 산형과 한약재의 혈관이완 및 혈압강하 효능에 대한 문헌고찰

Vasorelaxant or hypotensive effects of herbal medicines belong to Umbelliferae family: a review

  • 김범정 (경희사이버대학교 한방건강관리학과) ;
  • 최호영 (경희대학교 한의과대학 본초학교실)
  • Kim, Bumjung (Department of Oriental Health Management, Kyung Hee Cyber University) ;
  • Choi, Ho-Young (Department of Herbal pharmacology, College of Korean Medicine, Kyung Hee University)
  • 투고 : 2022.10.25
  • 심사 : 2022.11.25
  • 발행 : 2022.11.30
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초록

Objectives : The objective of this study was to investigate the possibility for the treatment of hypertension of herbal medicines belong to Umbelliferae family. Methods : Domestic and international articles about Herbology were investigated. A review was performed via the database (DB) search engines such as Pubmed, Korean studies Information Service System (KISS), KoreaScience, and Google Scholar. Hypertension-related terms including "vasorelaxation", "vasorelaxant", "vasodilation", "vasodilatory", "vasodilative", "hypotension", and "hypotensive" were performed as search terms. Results : A list was made about herbal medicines and origin plants belonging to the Umbelliferae family in Korean Pharmacopoeia 12 and Korean Herbal Pharmacopoeia. 14 herbal medicine and 22 origin plants were searched. Ostericum koreanum root and rhizome, Notopterygium incisum root and rhizome, N. forbesii root and rhizome, Ligusticum tenuissimum root and rhizome, L. jeholense root and rhizome, Angelica gigas root, A. dahurica root, A. dahurica var. formosana root, Bupleurum falcatum root, Peucedanum japonicum root, P. praeruptorum root, A. decursiva root, Cnidium officinale rhizome, L. chuanxiong rhizome, Foeniculum vulgare fruit, and Ferula assa-foetida resin and stem showed significant vasorelaxant or hypotensive effects. Conclusion : These review results showed that Osterici seu Notopterygii Radix et Rhizoma, Ligustici Tenuissimi Rhizoma et Radix, Angelicae Gigantis Radix, Angelicae Dahuricae Radix, Bupleuri Radix, Peucedani Japonici Radix, Peucedani Radix, Cnidii Rhizoma, Foeniculi Fructus, and Ferulae Resina had vasorelaxant or hypotensive effects. The results are expected as basic data in clinical trials and experimental researches for the treatment of hypertension of herbal medicines.

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참고문헌

  1. Nichols H, Cannon CP, Scirica BM, Fisher NDL. A remote hypertension management program clinical algorithm. Clin Cardiol. 2022.
  2. Jeong E, Lee KS, Yang SK, Cho JH. Influence of Health Empowerment, Spousal Support, and Posttraumatic Growth on Health Behavior in Patients with Coronary Artery Disease. Journal of Korean Biological Nursing Science. 2022 ; 24(2) : 113-21. https://doi.org/10.7586/jkbns.2022.24.2.113
  3. Laurent S. Antihypertensive drugs. Pharmacol Res. 2017 ; 124 : 116-25. https://doi.org/10.1016/j.phrs.2017.07.026
  4. Kamboj V .P. Herbal medicine. Current Science. 2000 ; 78(1) : 35-9.
  5. Rastogi S, Pandey MM, Rawat AKS. Traditional herbs: a remedy for cardiovascular disorders. Phytomedicine. 2016 ; 23(11) : 1082-9. https://doi.org/10.1016/j.phymed.2015.10.012
  6. Downie SR, Katz-Downie DS, Watson MF. A phylogeny of the flowering plant family Apiaceae based on chloroplast DNA rpl16 and rpoC1 intron sequences: towards a suprageneric classification of subfamily Apioideae. Am J Bot. 2000 ; 87(2) : 273-92. https://doi.org/10.2307/2656915
  7. Kim B, Kwon Y, Lee S, Lee K, Ham I, Choi HY. Vasorelaxant effects of Angelica decursiva root on isolated rat aortic rings. BMC Complement Altern Med. 2017 ; 17(1).
  8. Lee K, Park G, Ham I, Yang G, Lee M, Bu Y, Kim H, Choi HY. Vasorelaxant effect of Osterici radix ethanol extract on rat aortic rings. Evid Based Complement Alternat Med. 2013.
  9. Lee KJ, Kim DS, Kim HK, Bu YM, Kim HC, Ham IH, Choi HY. Vasorelaxant Effect of Gangwhal in Korean and Chinese on Rat Thoracic Aorta Rings. The Korea Jounrnal of Herbology. 2010 ; 25(4) : 69-75.
  10. Kim MH, Kim YG, Lee JH, Hong KP, Hong JK, Kong YJ, Lee HY. Screening of Biologically Active Essential Oils from Ligusticum tenuissimum. Korean Journal of Applied Microbiology and Biotechnology. 2000 ; 28(2) : 97-104. Min Hae, Young Gil Kim, Jin Ha Lee, Keo Pyo Hong, Jung Ki Hong, Young Joon Kong. (2000). Articles : Screening of Biologically Active Essential Oils from Ligusticum tenuissimum. Korean Journal of Applied Microbiology and Biotechnology, 28(2), 97-104.
  11. Kim B, Lee K, Chinannai KS, Ham I, Bu Y, Kim H, Choi HY. Endothelium-Independent Vasorelaxant Effect of Ligusticum jeholense Root and Rhizoma on Rat Thoracic Aorta. Molecules. 2015 ; 20(6) : 10721-33. https://doi.org/10.3390/molecules200610721
  12. Kim E, Lee K, Kim D, Rhyu M. Vasorelaxant Activities of Aqueous Extracts from Twenty Medicinal Plants Used in Oriental Medicines in Isolated Rat Aorta. Nutraceuticals and food. 2010 ; 15(3) : 189-95.
  13. Han JH, Choi MH, Nam TS, Ryu DG. Effects of Several Herbs on the Blood Vessel. Herbal formula science. 1999 ; 7(1) : 167-81.
  14. Lee K, Shin MS, Ham I, Choi HY. Investigation of the mechanisms of Angelica dahurica root extractinduced vasorelaxation in isolated rat aortic rings. BMC Complement Altern Med. 2015 ; 15(1).
  15. Nie H, Meng LZ, Zhou JY, Fan XF, Luo Y, Zhang GW. Imperatorin is responsible for the vasodilatation activity of Angelica Dahurica var. formosana regulated by nitric oxide in an endothelium-dependent manner. Chin J Integr Med. 2009 ; 15(6) : 442-7. https://doi.org/10.1007/s11655-009-0442-z
  16. Lee JW, Roh TC, Rho MC, Kim YK, Lee HS. Mechanisms of relaxant action of a pyranocoumarin from Peucedanum japonicum in isolated rat thoracic aorta. Planta Med. 2002 ; 68(10) :891-5. https://doi.org/10.1055/s-2002-34934
  17. Li Z, Zhang F, Wang S, Xiao H, Wang J, Li X, Yang H. Endothelium-dependent vasorelaxant effects of praeruptorin a in isolated rat thoracic aorta. Bioengineered. 2022 ; 13(4) : 10038-46. https://doi.org/10.1080/21655979.2022.2062979
  18. Ji Y, Rao MR. Effects of Peucedanum praeruptorum extractum on blood pressure, left ventricular hypertrophy and hemodynamic changes in left ventricular hypertrophied hypertensive rats. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1996 ; 16(11) : 676-8.
  19. Kim B, Kwon Y, Lee S, Lee K, Ham I, Choi HY. Vasorelaxant effects of Angelica decursiva root on isolated rat aortic rings. BMC Complement Altern Med. 2017 ; 17(1).
  20. Lee HW, Cho HG, Park YK. The Study on Antioxidative Effects and Quality Comparison of Ligusticum chuanxiong and Cnidium officinale (2) - Vascular Relaxant Effect of Cnidii rhizoma and Cnidii rhizoma - Angelicae radix Compound -. The Korea Jounrnal of Herbology. 1999 ; 14(1) : 55-60.
  21. Liang MJ, He LC, Yang G de. Screening, analysis and in vitro vasodilatation of effective components from Ligusticum Chuanxiong. Life Sci. 2005 ; 78(2) : 128-33. https://doi.org/10.1016/j.lfs.2005.04.038
  22. Chiou WF, Huang YL, Chen CF, Chen CC. Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum. Planta Med. 2001 ; 67(3) : 282-4. https://doi.org/10.1055/s-2001-12013
  23. Kim HH, Ahn SH, Park SY. Effects of Torilis Fructus Extract on the Relaxation of Corpus Cavernosum. Journal of Physiology & Pathology in Korean Medicine. 2018 ; 32(1) :24-9. https://doi.org/10.15188/kjopp.2018.02.32.1.24
  24. Bardai S el, Lyoussi B, Wibo M, Morel N. Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat. Clin Exp Hypertens. 2001 ; 23(4) : 329-43. https://doi.org/10.1081/CEH-100102671
  25. Kim SJ, Song BK, Lee EJ, Kim HK, Kim JK. Effects of Radix Angelicae Gigantis and Resina Ferulae on the Relaxation of Smooth Muscle and Expression of iNOS. Journal of Korean Oriental Medicine. 2000 ; 21(2) : 60-7.
  26. Safaeian L, Ghannadi A, Javanmard SH, Vahidian MH. The effect of hydroalcoholic extract of Ferula foetida stems on blood pressure and oxidative stress in dexamethasone-induced hypertensive rats. Res Pharm Sci. 2015 ; 10(4) : 326-34.