Journal of Ginseng Research

  • 제46권6호
  • /
  • Pages.731-737
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  • 2022
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  • 1226-8453(pISSN)
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  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
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Impact of HIV-1 subtypes on gross deletion in the nef gene after Korean Red Ginseng treatment

  • Cho, Young-Keol (Departments of Microbiology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim, Jung-Eun (Departments of Microbiology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Lee, Jinny (Departments of Microbiology, University of Ulsan College of Medicine, Asan Medical Center)
  • 투고 : 2021.08.18
  • 심사 : 2022.02.22
  • 발행 : 2022.11.01
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초록

Background: The number of primary human immunodeficiency virus (HIV)-1 non-B subtype infections (non-B) and that of reports regarding the differences in the pathogenesis of subtype B and non-B infections are increasing. However, to the best of our knowledge, there have been no reports on gross deletion in the nef gene (g∆nef) in non-B infections. Methods: To determine whether there is a difference in the change in CD4+ T cells after treatment with Korean Red Ginseng (KRG) between patients with subtype B and non-B infections, we retrospectively analyzed and compared the annual decrease in CD4+ T cells (AD) and the proportion of g∆nef in 77 patients who were followed for more than 10 years in the absence of combination antiretroviral therapy. Results: Overall, AD was significantly faster in patients with non-B infections than in those with subtype B infections. Survival analysis showed that the survival probability was significantly higher in subtype B than in non B-infected patients. These differences mainly resulted from significant differences in the amount of KRG and age. In the patients treated with KRG, there was a significant correlation between the amount of KRG and the AD in both subtypes. Interestingly, there was a significant correlation between the amount of KRG and the proportion of g∆nef in patients infected with subtype B, but not in those infected with non-B. The same phenomenon was observed when the KRG dose was adjusted. Conclusion: Our results suggest that non-B may be biologically more stable than subtype B.

키워드

과제정보

This study was supported by a grant from the Korean Society of Ginseng (2020).

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