Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Modulation of Reactive Oxygen Species to Overcome 5-Fluorouracil Resistance

  • Received : 2022.01.28
  • Accepted : 2022.03.30
  • Published : 2022.11.01
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Abstract

5-Fluorouracil (5-FU) remains to be an important chemotherapeutic drug for treating several cancers when targeted therapy is unavailable. Chemoresistance limits the clinical utility of 5-FU, and new strategies are required to overcome the resistance. Reactive oxygen species (ROS) and antioxidants are balanced differently in both normal and cancer cells. Modulating ROS can be one method of overcoming 5-FU resistance. This review summarizes selected compounds and endogenous cellular targets modulating ROS generation to overcome 5-FU resistance.

Keywords

Acknowledgement

This work was supported by research grants from Daegu Catholic University in 2020.

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