Acknowledgement
This study was supported by the Korea Research Foundation and the NRF grant funded by the Korea Government (MSIP) (NRF-2021R1A4A1029238).
References
- Beauchamp RO Jr, Bus JS, Popp JA, Boreiko CJ and Andjelkovich DA (1984) A critical review of the literature on hydrogen sulfide toxicity. Crit Rev Toxicol 13, 25-97 https://doi.org/10.3109/10408448409029321
- Wang R (2002) Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? FASEB J 16, 1792-1798 https://doi.org/10.1096/fj.02-0211hyp
- Aroca A, Gotor C and Romero LC (2018) Hydrogen sulfide signaling in plants: emerging roles of protein persulfidation. Front Plant Sci 9, 1369 https://doi.org/10.3389/fpls.2018.01369
- Dombkowski RA, Russell MJ and Olson KR (2004) Hydrogen sulfide as an endogenous regulator of vascular smooth muscle tone in trout. Am J Physiol Regul Integr Comp Physiol 286, 678-685
- Wojcicka G, Jamroz-Wisniewska A, Atanasova P, Chaldakov GN, Chylinska-Kula B and Beltowski J (2011) Differential effects of statins on endogenous H2S formation in perivascular adipose tissue. Pharmacol Res 63, 68-76 https://doi.org/10.1016/j.phrs.2010.10.011
- Abe K and Kimura H (1996) The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 16, 1066-1071 https://doi.org/10.1523/JNEUROSCI.16-03-01066.1996
- Kimura H (2002) Hydrogen sulfide as a neuromodulator. Mol Neurobiol 26, 13-19 https://doi.org/10.1385/MN:26:1:013
- Li L, Rose P and Moore PK (2011) Hydrogen sulfide and cell signaling. Annu Rev Pharmacol Toxicol 51, 169-187 https://doi.org/10.1146/annurev-pharmtox-010510-100505
- Xiao Q, Ying J, Xiang L and Zhang C (2018) The biologic effect of hydrogen sulfide and its function in various diseases. Medicine (Baltimore) 97, e13065 https://doi.org/10.1097/MD.0000000000013065
- Han Y, Shang Q, Yao J and Ji Y (2019) Hydrogen sulfide: a gaseous signaling molecule modulates tissue homeostasis: implications in ophthalmic diseases. Cell Death Dis 10, 293 https://doi.org/10.1038/s41419-019-1525-1
- Whiteman M and Winyard PG (2011) Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promising. Expert Rev Clin Pharmacol 4, 13-32 https://doi.org/10.1586/ecp.10.134
- Bhatia M and Gaddam RR (2021) Hydrogen sulfide in inflammation: a novel mediator and therapeutic target. Antioxid Redox Signal 34, 1368-1377 https://doi.org/10.1089/ars.2020.8211
- Ryazantseva NV, Novitsky VV, Starikova EG, Kleptsova LA, Jakushina VD and Kaigorodova EV (2011) Role of hydrogen sulfide in the regulation of cell apoptosis. Bull Exp Biol Med 151, 702-704 https://doi.org/10.1007/s10517-011-1420-y
- Li X, Chen M, Shi Q, Zhang H and Xu S (2020) Hydrogen sulfide exposure induces apoptosis and necroptosis through lncRNA3037/miR-15a/BCL2-A20 signaling in broiler trachea. Sci Total Environ 699, 134296 https://doi.org/10.1016/j.scitotenv.2019.134296
- Zaichko NV, Melnik AV, Yoltukhivskyy MM, Olhovskiy AS and Palamarchuk IV (2014) Hydrogen sulfide: metabolism, biological and medical role. Ukr Biochem J 86, 5-25
- Arif MS, Yasmeen T, Abbas Z et al (2020) Role of exogenous and endogenous hydrogen sulfide (H2S) on functional traits of plants under heavy metal stresses: a recent perspective. Front Plant Sci 11, 545453
- Norris EJ, Culberson CR, Narasimhan S and Clemens MG (2011) The liver as a central regulator of hydrogen sulfide. Shock 36, 242-250 https://doi.org/10.1097/SHK.0b013e3182252ee7
- Wu DD, Wang DY, Li HM, Guo JC, Duan SF and Ji XY (2019) Hydrogen sulfide as a novel regulatory factor in liver health and disease. Oxid Med Cell Longev 2019, 3831713
- Sun HJ, Wu ZY, Nie XW, Wang XY and Bian JS (2021) Implications of hydrogen sulfide in liver pathophysiology: mechanistic insights and therapeutic potential. J Adv Res 27, 127-135 https://doi.org/10.1016/j.jare.2020.05.010
- Hellmich MR and Szabo C (2015) Hydrogen sulfide and cancer. Handb Exp Pharmacol 230, 233-241 https://doi.org/10.1007/978-3-319-18144-8_12
- Wang SS, Chen YH, Chen N et al (2017) Hydrogen sulfide promotes autophagy of hepatocellular carcinoma cells through the PI3K/Akt/mTOR signaling pathway. Cell Death Dis 8, e2688 https://doi.org/10.1038/cddis.2017.18
- Filliol A and Schwabe RF (2019) Contributions of fibroblasts, extracellular matrix, stiffness, and mechanosensing to hepatocarcinogenesis. Semin Liver Dis 39, 315-333 https://doi.org/10.1055/s-0039-1685539
- Malone Rubright SL, Pearce LL and Peterson J (2017) Environmental toxicology of hydrogen sulfide. Nitric Oxide 71, 1-13 https://doi.org/10.1016/j.niox.2017.09.011
- Doujaiji B and Al-Tawfiq JA (2010) Hydrogen sulfide exposure in an adult male. Ann Saudi Med 30, 76-80 https://doi.org/10.5144/0256-4947.59379
- Ahmad A, Gero D, Olah G and Szabo C (2016) Effect of endotoxemia in mice genetically deficient in cystathioninegamma-lyase, cystathionine-beta-synthase or 3-mercaptopyruvate sulfurtransferase. Int J Mol Med 38, 1683-1692 https://doi.org/10.3892/ijmm.2016.2771
- Tao B, Wang R, Sun C and Zhu Y (2017) 3-Mercaptopyruvate sulfurtransferase, not cystathionine beta-synthase nor cystathionine gamma-lyase, mediates hypoxia-induced migration of vascular endothelial cells. Front Pharmacol 8, 657 https://doi.org/10.3389/fphar.2017.00657
- Ahmad A, Druzhyna N and Szabo C (2019) Effect of 3-mercaptopyruvate sulfurtransferase deficiency on the development of multiorgan failure, inflammation, and wound healing in mice subjected to burn injury. J Burn Care Res 40, 148-156 https://doi.org/10.1093/jbcr/irz007
- Augsburger F and Szabo C (2020) Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H2S) pathway in cancer cells. Pharmacol Res 154, 104083 https://doi.org/10.1016/j.phrs.2018.11.034
- Cao X, Ding L, Xie ZZ et al (2019) A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer? Antioxid Redox Signal 31, 1-38 https://doi.org/10.1089/ars.2017.7058
- Shibuya N, Koike S, Tanaka M et al (2013) A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells. Nat Commun 4, 1366 https://doi.org/10.1038/ncomms2371
- Polhemus DJ and Lefer DJ (2014) Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease. Circ Res 114, 730-737 https://doi.org/10.1161/CIRCRESAHA.114.300505
- Murphy B, Bhattacharya R and Mukherjee P (2019) Hydrogen sulfide signaling in mitochondria and disease. FASEB J 33, 13098-13125 https://doi.org/10.1096/fj.201901304R
- Pedre B and Dick TP (2021) 3-Mercaptopyruvate sulfurtransferase: an enzyme at the crossroads of sulfane sulfur trafficking. Biol Chem 402, 223-237 https://doi.org/10.1515/hsz-2020-0249
- Stipanuk MH and Beck PW (1982) Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat. Biochem J 206, 267-277 https://doi.org/10.1042/bj2060267
- Nandi SS and Mishra PK (2017) H2S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes. Sci Rep 7, 3639 https://doi.org/10.1038/s41598-017-03776-9
- Cooper AJ (1983) Biochemistry of sulfur-containing amino acids. Annu Rev Biochem 52, 187-222 https://doi.org/10.1146/annurev.bi.52.070183.001155
- Hipolito A, Nunes SC, Vicente JB and Serpa J (2020) Cysteine aminotransferase (CAT): a pivotal sponsor in metabolic remodeling and an ally of 3-mercaptopyruvate sulfurtransferase (MST) in cancer. Molecules 25, 3984 https://doi.org/10.3390/molecules25173984
- Mikami Y and Kimura H (2012) A mechanism of retinal protection from light-induced degeneration by hydrogen sulfide. Commun Integr Biol 5, 169-171 https://doi.org/10.4161/cib.18679
- Guo W, Kan JT, Cheng ZY et al (2012) Hydrogen sulfide as an endogenous modulator in mitochondria and mitochondria dysfunction. Oxid Med Cell Longev 2012, 878052
- Wu D, Zheng N, Qi K et al (2015) Exogenous hydrogen sulfide mitigates the fatty liver in obese mice through improving lipid metabolism and antioxidant potential. Med Gas Res 5, 1 https://doi.org/10.1186/s13618-014-0022-y
- Wu D, Zhong P, Wang Y et al (2020) Hydrogen sulfide attenuates high-fat diet-induced non-alcoholic fatty liver disease by inhibiting apoptosis and promoting autophagy via reactive oxygen species/phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling pathway. Front Pharmacol 11, 585860 https://doi.org/10.3389/fphar.2020.585860
- Comas F and Moreno-Navarrete JM (2021) The impact of H2S on obesity-associated metabolic disturbances. Antioxidants (Basel) 10, 633 https://doi.org/10.3390/antiox10050633
- Wang P and Wu L (2018) Hydrogen sulfide and nonalcoholic fatty liver disease. Hepatobiliary Surg Nutr 7, 122-124 https://doi.org/10.21037/hbsn.2018.03.03
- Carter RN, Gibbins MTG, Barrios-Llerena ME et al (2021) The hepatic compensatory response to elevated systemic sulfide promotes diabetes. Cell Rep 37, 109958 https://doi.org/10.1016/j.celrep.2021.109958
- Pineiro-Ramil M, Burguera EF, Hermida-Gomez T et al (2022) Reduced levels of H2S in diabetes-associated osteoarthritis are linked to hyperglycaemia, Nrf-2/HO-1 signalling downregulation and chondrocyte dysfunction. Antioxidants (Basel) 11, 628 https://doi.org/10.3390/antiox11040628
- Gorini F, Del Turco S, Sabatino L, Gaggini M and Vassalle C (2021) H2S as a bridge linking inflammation, oxidative stress and endothelial biology: a possible defense in the fight against SARS-CoV-2 infection? Biomedicines 9, 1107 https://doi.org/10.3390/biomedicines9091107
- Jensen-Cody SO and Potthoff MJ (2021) Hepatokines and metabolism: deciphering communication from the liver. Mol Metab 44, 101138 https://doi.org/10.1016/j.molmet.2020.101138
- Grant DM (1991) Detoxification pathways in the liver. J Inherit Metab Dis 14, 421-430 https://doi.org/10.1007/BF01797915
- Melaram R (2021) Environmental risk factors implicated in liver disease: a mini-review. Front Public Health 9, 683719 https://doi.org/10.3389/fpubh.2021.683719
- Tan G, Pan S, Li J et al (2011) Hydrogen sulfide attenuates carbon tetrachloride-induced hepatotoxicity, liver cirrhosis and portal hypertension in rats. PLoS One 6, e25943 https://doi.org/10.1371/journal.pone.0025943
- Mateus I and Prip-Buus C (2022) Hydrogen sulphide in liver glucose/lipid metabolism and non-alcoholic fatty liver disease. Eur J Clin Invest 52, e13680 https://doi.org/10.1111/eci.13680
- Previte DM, O'Connor EC, Novak EA, Martins CP, Mollen KP and Piganelli JD (2017) Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation. PLoS One 12, e0175549 https://doi.org/10.1371/journal.pone.0175549
- Snezhkina AV, Kudryavtseva AV, Kardymon OL et al (2019) ROS generation and antioxidant defense systems in normal and malignant cells. Oxid Med Cell Longev 2019, 6175804
- Peng HY, Lucavs J, Ballard D et al (2021) Metabolic reprogramming and reactive oxygen species in T cell immunity. Front Immunol 12, 652687 https://doi.org/10.3389/fimmu.2021.652687
- Li L, Salto-Tellez M, Tan CH, Whiteman M and Moore PK (2009) GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat. Free Radic Biol Med 47, 103-113 https://doi.org/10.1016/j.freeradbiomed.2009.04.014
- Xia M, Zhang Y, Jin K, Lu Z, Zeng Z and Xiong W (2019) Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer. Cell Biosci 9, 27 https://doi.org/10.1186/s13578-019-0289-8
- Brand MD, Orr AL, Perevoshchikova IV and Quinlan CL (2013) The role of mitochondrial function and cellular bioenergetics in ageing and disease. Br J Dermatol 169 Suppl 2, 1-8
- Degli Esposti D, Hamelin J, Bosselut N et al (2012) Mitochondrial roles and cytoprotection in chronic liver injury. Biochem Res Int 2012, 387626
- Modis K, Coletta C, Erdelyi K, Papapetropoulos A and Szabo C (2013) Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics. FASEB J 27, 601-611 https://doi.org/10.1096/fj.12-216507
- Jia J, Wang Z, Zhang M et al (2020) SQR mediates therapeutic effects of H2S by targeting mitochondrial electron transport to induce mitochondrial uncoupling. Sci Adv 6, eaaz5752 https://doi.org/10.1126/sciadv.aaz5752
- Paul BD, Snyder SH and Kashfi K (2021) Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics. Redox Biol 38, 101772 https://doi.org/10.1016/j.redox.2020.101772
- Shimizu Y, Polavarapu R, Eskla KL et al (2018) Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK. J Mol Cell Cardiol 116, 29-40 https://doi.org/10.1016/j.yjmcc.2018.01.011
- Mustafa AK, Gadalla MM, Sen N et al (2009) H2S signals through protein S-sulfhydration. Sci Signal 2, ra72
- Modis K, Ju Y, Ahmad A et al (2016) S-Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergetics. Pharmacol Res 113, 116-124 https://doi.org/10.1016/j.phrs.2016.08.023
- Nuttall FQ, Ngo A and Gannon MC (2008) Regulation of hepatic glucose production and the role of gluconeogenesis in humans: is the rate of gluconeogenesis constant? Diabetes Metab Res Rev 24, 438-458 https://doi.org/10.1002/dmrr.863
- Cruz-Pineda WD, Parra-Rojas I, Rodriguez-Ruiz HA, Illades-Aguiar B, Matia-Garcia I and Garibay-Cerdenares OL (2022) The regulatory role of insulin in energy metabolism and leukocyte functions. J Leukoc Biol 111, 197-208
- Han HS, Kang G, Kim JS, Choi BH and Koo SH (2016) Regulation of glucose metabolism from a liver-centric perspective. Exp Mol Med 48, e218 https://doi.org/10.1038/emm.2015.122
- Irimia JM, Meyer CM, Segvich DM et al (2017) Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice. J Biol Chem 292, 10455-10464 https://doi.org/10.1074/jbc.M117.786525
- Manna P, Gungor N, McVie R and Jain SK (2014) Decreased cystathionine-gamma-lyase (CSE) activity in livers of type 1 diabetic rats and peripheral blood mononuclear cells (PBMC) of type 1 diabetic patients. J Biol Chem 289, 11767-11778 https://doi.org/10.1074/jbc.M113.524645
- Untereiner AA, Wang R, Ju Y and Wu L (2016) Decreased gluconeogenesis in the absence of cystathionine gamma-lyase and the underlying mechanisms. Antioxid Redox Signal 24, 129-140 https://doi.org/10.1089/ars.2015.6369
- Li N, Wang MJ, Jin S et al (2016) The H2S donor NaHS changes the expression pattern of h2s-producing enzymes after myocardial infarction. Oxid Med Cell Longev 2016, 6492469
- Dhamija E, Paul SB and Kedia S (2019) Non-alcoholic fatty liver disease associated with hepatocellular carcinoma: an increasing concern. Indian J Med Res 149, 9-17 https://doi.org/10.4103/ijmr.IJMR_1456_17
- Rada P, Gonzalez-Rodriguez A, Garcia-Monzon C and Valverde AM (2020) Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver? Cell Death Dis 11, 802 https://doi.org/10.1038/s41419-020-03003-w
- Raman M and Allard J (2006) Non alcoholic fatty liver disease: a clinical approach and review. Can J Gastroenterol 20, 345-349 https://doi.org/10.1155/2006/918262
- Li M, Xu C, Shi J et al (2018) Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway. Gut 67, 2169-2180 https://doi.org/10.1136/gutjnl-2017-313778
- Nguyen TTP, Kim DY, Lee YG et al (2021) SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice. Mol Cell 81, 3820-3832 e3827 https://doi.org/10.1016/j.molcel.2021.06.003
- Nguyen TTP, Kim DY, Im SS and Jeon TI (2021) Impairment of ULK1 sulfhydration-mediated lipophagy by SREBF1/SREBP-1c in hepatic steatosis. Autophagy 17, 4489-4490 https://doi.org/10.1080/15548627.2021.1968608
- Lan A, Liao X, Mo L et al (2011) Hydrogen sulfide protects against chemical hypoxia-induced injury by inhibiting ROS-activated ERK1/2 and p38MAPK signaling pathways in PC12 cells. PLoS One 6, e25921 https://doi.org/10.1371/journal.pone.0025921
- Hine C, Harputlugil E, Zhang Y et al (2015) Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell 160, 132-144 https://doi.org/10.1016/j.cell.2014.11.048
- Minamishima S, Bougaki M, Sips PY et al (2009) Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice. Circulation 120, 888-896 https://doi.org/10.1161/CIRCULATIONAHA.108.833491
- Jiang T, Yang W, Zhang H, Song Z, Liu T and Lv X (2020) Hydrogen sulfide ameliorates lung ischemiareperfusion injury through SIRT1 signaling pathway in type 2 diabetic rats. Front Physiol 11, 596
- Liu H, Bai XB, Shi S and Cao YX (2009) Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats. J Pharm Pharmacol 61, 207-212 https://doi.org/10.1211/jpp.61.02.0010
- Sekijima M, Sahara H, Miki K et al (2017) Hydrogen sulfide prevents renal ischemia-reperfusion injury in CLAWN miniature swine. J Surg Res 219, 165-172 https://doi.org/10.1016/j.jss.2017.05.123
- Elrod JW, Calvert JW, Morrison J et al (2007) Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proc Natl Acad Sci U S A 104, 15560-15565 https://doi.org/10.1073/pnas.0705891104
- Takahashi H, Shigefuku R, Yoshida Y et al (2014) Correlation between hepatic blood flow and liver function in alcoholic liver cirrhosis. World J Gastroenterol 20, 17065-17074 https://doi.org/10.3748/wjg.v20.i45.17065
- Iwakiri Y, Shah V and Rockey DC (2014) Vascular pathobiology in chronic liver disease and cirrhosis - current status and future directions. J Hepatol 61, 912-924 https://doi.org/10.1016/j.jhep.2014.05.047
- Coulouarn C and Clement B (2014) Stellate cells and the development of liver cancer: therapeutic potential of targeting the stroma. J Hepatol 60, 1306-1309 https://doi.org/10.1016/j.jhep.2014.02.003
- Zhang F, Jin H, Wu L et al (2017) Diallyl trisulfide suppresses oxidative stress-induced activation of hepatic stellate cells through production of hydrogen sulfide. Oxid Med Cell Longev 2017, 1406726
- Damba T, Zhang M, Buist-Homan M, van Goor H, Faber KN and Moshage H (2019) Hydrogen sulfide stimulates activation of hepatic stellate cells through increased cellular bio-energetics. Nitric Oxide 92, 26-33 https://doi.org/10.1016/j.niox.2019.08.004
- Wedmann R, Bertlein S, Macinkovic I et al (2014) Working with "H2S": facts and apparent artifacts. Nitric Oxide 41, 85-96 https://doi.org/10.1016/j.niox.2014.06.003
- Zheng Y, Ji X, Ji K and Wang B (2015) Hydrogen sulfide prodrugs-a review. Acta Pharm Sin B 5, 367-377 https://doi.org/10.1016/j.apsb.2015.06.004
- Xie X, Dai H, Zhuang B, Chai L, Xie Y and Li Y (2016) Exogenous hydrogen sulfide promotes cell proliferation and differentiation by modulating autophagy in human keratinocytes. Biochem Biophys Res Commun 472, 437-443 https://doi.org/10.1016/j.bbrc.2016.01.047
- Phillips CM, Zatarain JR, Nicholls ME et al (2017) Upregulation of cystathionine-beta-synthase in colonic epithelia reprograms metabolism and promotes carcinogenesis. Cancer Res 77, 5741-5754
- Fan HN, Wang HJ, Yang-Dan CR et al (2013) Protective effects of hydrogen sulfide on oxidative stress and fibrosis in hepatic stellate cells. Mol Med Rep 7, 247-253 https://doi.org/10.3892/mmr.2012.1153
- Robert K, Nehme J, Bourdon E et al (2005) Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver. Gastroenterology 128, 1405-1415 https://doi.org/10.1053/j.gastro.2005.02.034
- Ci L, Yang X, Gu X et al (2017) Cystathionine gammalyase deficiency exacerbates CCl4-Induced acute hepatitis and fibrosis in the mouse liver. Antioxid Redox Signal 27, 133-149 https://doi.org/10.1089/ars.2016.6773
- Zhao S, Song T, Gu Y et al (2021) Hydrogen sulfide alleviates liver injury through the S-sulfhydrated-kelchlike ECH-associated protein 1/nuclear erythroid 2-related factor 2/low-density lipoprotein receptor-related protein 1 pathway. Hepatology 73, 282-302 https://doi.org/10.1002/hep.31247
- Wang B, Zeng J and Gu Q (2017) Exercise restores bioavailability of hydrogen sulfide and promotes autophagy influx in livers of mice fed with high-fat diet. Can J Physiol Pharmacol 95, 667-674 https://doi.org/10.1139/cjpp-2016-0611
- Scammahorn JJ, Nguyen ITN, Bos EM, Van Goor H and Joles JA (2021) Fighting oxidative stress with sulfur: hydrogen sulfide in the renal and cardiovascular systems. Antioxidants (Basel) 10, 373 https://doi.org/10.3390/antiox10030373
- Zhang S, Pan C, Zhou F et al (2015) Hydrogen sulfide as a potential therapeutic target in fibrosis. Oxid Med Cell Longev 2015, 593407
- Fan HN, Wang HJ, Ren L et al (2013) Decreased expression of p38 MAPK mediates protective effects of hydrogen sulfide on hepatic fibrosis. Eur Rev Med Pharmacol Sci 17, 644-652
- Wynn TA and Ramalingam TR (2012) Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med 18, 1028-1040 https://doi.org/10.1038/nm.2807
- Li XH, Xue WL, Wang MJ et al (2017) H2S regulates endothelial nitric oxide synthase protein stability by promoting microRNA-455-3p expression. Sci Rep 7, 44807 https://doi.org/10.1038/srep44807
- Fouad AA, Hafez HM and Hamouda A (2020) Hydrogen sulfide modulates IL-6/STAT3 pathway and inhibits oxidative stress, inflammation, and apoptosis in rat model of methotrexate hepatotoxicity. Hum Exp Toxicol 39, 77-85 https://doi.org/10.1177/0960327119877437
- Zeng J, Lin X, Fan H and Li C (2013) Hydrogen sulfide attenuates the inflammatory response in a mouse burn injury model. Mol Med Rep 8, 1204-1208 https://doi.org/10.3892/mmr.2013.1610
- Mao YQ and Fan XM (2015) Autophagy: a new therapeutic target for liver fibrosis. World J Hepatol 7, 1982-1986 https://doi.org/10.4254/wjh.v7.i16.1982
- Singh KK, Lovren F, Pan Y et al (2015) The essential autophagy gene ATG7 modulates organ fibrosis via regulation of endothelial-to-mesenchymal transition. J Biol Chem 290, 2547-2559 https://doi.org/10.1074/jbc.M114.604603
- Lucantoni F, Martinez-Cerezuela A, Gruevska A et al (2021) Understanding the implication of autophagy in the activation of hepatic stellate cells in liver fibrosis: are we there yet? J Pathol 254, 216-228 https://doi.org/10.1002/path.5678
- Lv S, Liu H and Wang H (2021) Exogenous hydrogen sulfide plays an important role by regulating autophagy in diabetic-related diseases. Int J Mol Sci 22, 6715 https://doi.org/10.3390/ijms22136715