대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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간암에 대한 한약치료: 체계적 문헌고찰 및 메타분석의 프로토콜

Herbal Medicine for Liver Cancer: A Protocol for Systematic Review and Meta-Analysis

  • 권승원 (경희대학교 한의과대학 순환신경내과학교실) ;
  • 송가연 (강원대학교 약학대학) ;
  • 양승보 (가천대학교 한의과대학 내과학교실)
  • Kwon, Seungwon (Dept. of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University) ;
  • Song, Ga Yeon (Dept. of Pharmacy, Kangwon National University) ;
  • Yang, Seung-Bo (Dept. of Korean Internal Medicine, College of Korean Medicine, Gachon University)
  • 투고 : 2020.07.30
  • 심사 : 2020.09.30
  • 발행 : 2022.09.30
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초록

서론: 본 체계적 문헌 고찰의 프로토콜 논문은 간암의 한약 치료에 대한 효과와 안전성의 근거를 제시하는 것을 목표로 한다. 방법: 본 체계적 문헌 고찰은 간암에 한약 치료에 대한 무작위 대조 임상시험을 포함할 것이다. 오직 무작위 대조 임상시험 유형의 임상 연구만 포함할 것이다. 시험군의 한약 치료는 한약을 사용한 모든 제형을 포함할 것이며, 대조군은 다른 치료, 플라시보 치료, 서양의학적 치료 등을 포함할 것이다. 다음 11개의 데이터베이스를 활용하여 검색할 것이다: the Cochrane Database of Systematic Reviews, MEDLINE, EMBASE, AMED, CINAHL, Chinese database(CNKI), 그리고 다섯 개의 한국데이터베이스(OASIS, DBpia, RISS, KISS, and NDSL). 연구의 선정, 데이터 추출 및 분석 등의 업무는 3명의 연구자가 독립적으로 수행할 것이다. 비뚤림 위험 평가를 포함한 연구의 질적 평가는 Cochrane risk-of-bias assessment tool을 사용할 것이다. 결과: 본 간암에 대한 한약 치료의 체계적 문헌 고찰은 최신의 근거를 요약적이고 분석적으로 제공할 것이다. 결론: 간암의 한약 치료에 대한 효과와 안전성의 근거를 제시할 것이며, 이는 종양학이나 한의학과 보완·대체의료 분야의 종사자들에게 유용한 정보를 제공할 것이다.

Introduction: The aim of this systematic review is to provide evidence confirming the efficacy and safety of herbal medicines used in the treatment of liver cancer. Methods: The review will include randomized clinical trials that compared herbal medicines used as treatments for liver cancer with other therapies, such as placebos and Western medicine. Only randomized controlled trials will be included in this review, and all types of herbal medicine will be evaluated. Eleven electronic databases will be searched from the inception date: the Cochrane Database of Systematic Reviews, MEDLINE, EMBASE, AMED, CINAHL, one Chinese database (CNKI), and five Korean databases (OASIS, DBpia, RISS, KISS, and NDSL). The selection of studies, data extraction, and management will be performed independently by four researchers. Methodological quality, including the risk of bias, will be assessed using the Cochrane risk-of-bias assessment tool. Results: The review of current evidence for the effectiveness of herbal medicine for liver cancer will be summarized and quantitatively analyzed. Conclusions: Our systematic review will provide evidence of the efficacy of herbal medicines as treatments for liver cancer. This evidence will provide useful information for practitioners and patients in the fields of oncology and complementary medicine.

키워드

과제정보

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2022R1G1A1003601). The authors have no conflicts of interest to disclose.

참고문헌

  1. Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumours of the digestive system. Lyon: World Health Organization; 2010, p. 251-3.
  2. Motola-Kuba D, Zamora-Valdes D, Uribe M, Mendez-Sanchez N. Hepatocellular carcinoma. An overview. Annals of hepatology 2006;5(1):16-24. https://doi.org/10.1016/S1665-2681(19)32034-4
  3. Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR. A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nature Reviews Gastroenterology & Hepatology 2019;16(10):589-604. https://doi.org/10.1038/s41575-019-0186-y
  4. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68(6):394-424. https://doi.org/10.3322/caac.21492
  5. Liu CY, Chen KF, Chen PJ. Treatment of Liver Cancer. Cold Spring Harb Perspect Med 2015;5(9):a021535. https://doi.org/10.1101/cshperspect.a021535
  6. Ma L, Wang B, Long Y, Li H. Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a systematic review with meta-analysis. Front Med 2017;11(2):191-202. https://doi.org/10.1007/s11684-017-0512-0
  7. Wu P, Dugoua JJ, Eyawo O, Mills EJ. Traditional Chinese Medicines in the treatment of hepatocellular cancers: a systematic review and meta-analysis. J Exp Clin Cancer Res 2009;28(1):112. https://doi.org/10.1186/1756-9966-28-112
  8. Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). Cochrane: 2019.
  9. Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315(7109):629-34. https://doi.org/10.1136/bmj.315.7109.629