Advances in nano research

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Geometry effect in the drug delivery for therapy with nanomedicines based on the conditions of the sport

  • Zhu, Lemei (Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations) ;
  • Zou, Xuemin (Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations) ;
  • Li, Xi (Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations) ;
  • Zhang, Yuan (Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations) ;
  • Liu, Juan (Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations) ;
  • Xiang, Yuhan (Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations)
  • Received : 2021.12.27
  • Accepted : 2022.05.22
  • Published : 2022.09.25
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Abstract

This study investigates the geometrical impact on the nanomedicine drug delivery via nanodevices. A nanomotor made of the nanotube carrying the drug as the motor blade is considered in the blood flow. Physical activities change the blood flow, and sports training enhances the blood flow and plays a significant role in the stability of drug delivery devices. This paper studies the impact of geometrical parameters on the nanomotors carrying the nanomedicine. The effect of physical exercise on the dynamic response regarding the stability of drug delivery devices is discussed in detail.

Keywords

Acknowledgement

The present study was supported by the Application Characteristic Discipline of Hunan Province, the Hunan Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations (No. 2016TP1029), The Hunan Provincial Key Laboratory of Fundamental and Clinical Research on Functional Nucleic Acid. The Hunan Provincial Innovation Platform and Talents Program (No. 2018RS3105), The Hunan Provincial Education Commission Foundation (19B068, 20A056, 20C0202), The Hunan Provincial Health Commission Foundation (No. 202112041226), and the Funding by young backbone teachers of Hunan province training program foundation of Changsha Medical University (Hunan Education Bureau Notice 2021 No.29-26).

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