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Technetium-99m hand perfusion scintigraphy (Raynaud's scan) as a method of verification in hand arm vibration syndrome: a review

  • Taewoong Ha (Department of Occupational and Environmental Medicine, Kosin University Gospel Hospital) ;
  • Hyeoncheol Oh (Department of Occupational and Environmental Medicine, Kosin University Gospel Hospital) ;
  • Jungwon Kim (Department of Occupational and Environmental Medicine, Kosin University Gospel Hospital)
  • Received : 2022.04.14
  • Accepted : 2022.09.11
  • Published : 2022.12.31

Abstract

It is important to assess the blood flow of fingers in the verification of hand-arm vibration syndrome. In the Republic of Korea, most assessments of the blood flow in the fingers are performed using a cold provocation test with finger skin color change. However, this test is a non-objective method with a relatively low sensitivity, leading to possible social and legal problems. Thus, we reviewed the characteristics of several tests that assess the blood flow in the fingers. Among these tests, using the radioactive isotope method, Raynaud's scan has a relatively higher sensitivity and specificity than other tests, provides objective results, and is approachable in many hospitals. So we suggest using Raynaud's scan as an alternative test when cold provocation test with finger skin color change is negative in vibration exposed worker.

Keywords

References

  1. Pauling JD, Hughes M, Pope JE. Raynaud's phenomenon-an update on diagnosis, classification and management. Clin Rheumatol 2019;38(12):3317-30.  https://doi.org/10.1007/s10067-019-04745-5
  2. Gelber AC, Wigley FM, Stallings RY, Bone LR, Barker AV, Baylor I, et al. Symptoms of Raynaud's phenomenon in an inner-city African-American community: prevalence and self-reported cardiovascular comorbidity. J Clin Epidemiol 1999;52(5):441-6.  https://doi.org/10.1016/S0895-4356(99)00015-3
  3. Fraenkel L, Zhang Y, Chaisson CE, Maricq HR, Evans SR, Brand F, et al. Different factors influencing the expression of Raynaud's phenomenon in men and women. Arthritis Rheum 1999;42(2):306-10.  https://doi.org/10.1002/1529-0131(199902)42:2<306::AID-ANR13>3.0.CO;2-G
  4. Weinrich MC, Maricq HR, Keil JE, McGregor AR, Diat F. Prevalence of Raynaud phenomenon in the adult population of South Carolina. J Clin Epidemiol 1990;43(12):1343-9.  https://doi.org/10.1016/0895-4356(90)90101-T
  5. Heaver C, Goonetilleke KS, Ferguson H, Shiralkar S. Hand-arm vibration syndrome: a common occupational hazard in industrialized countries. J Hand Surg Eur Vol 2011;36(5):354-63.  https://doi.org/10.1177/1753193410396636
  6. Wasserman D, Taylor W, Behrens V, Samueloff S, Reynolds D. Vibration White Finger Disease in U.S. Workers Using Pneumatic Chipping and Grinding Hand Tools. Cincinnati, OH: National Institute for Occupational Safety and Health; 1982, 82-118.
  7. Bovenzi M. A longitudinal study of vibration white finger, cold response of digital arteries, and measures of daily vibration exposure. Int Arch Occup Environ Health 2010;83(3):259-72.  https://doi.org/10.1007/s00420-009-0461-2
  8. Wei N, Lin H, Chen T, Xiao B, Yan M, Lang L, et al. The hand-arm vibration syndrome associated with the grinding of handheld workpieces in a subtropical environment. Int Arch Occup Environ Health 2021;94(4):773-81.  https://doi.org/10.1007/s00420-020-01615-5
  9. Ministry of Employment and Labor. Result of Medical Examinations of Workers, 2020: Government Publications Registration Number (GPRN):11-1492000-000029-10. Sejong, Korea: Occupational Safety and Health Policy Bureau, Occupational Health Standard Division; 2021.
  10. Chetter IC, Kent PJ, Kester RC. The hand arm vibration syndrome: a review. Cardiovasc Surg 1998;6(1):1-9.  https://doi.org/10.1177/096721099800600101
  11. Maldonado G, Rios C. Raynaud's phenomenon associated with nitric acid: case report. Revista Colombiana de Reumatologia 2017;24(1):48-53.  https://doi.org/10.1016/j.rcreue.2017.03.003
  12. Olsen N. Diagnostic aspects of vibration-induced white finger. Int Arch Occup Environ Health 2002;75(1-2):6-13.  https://doi.org/10.1007/s004200100272
  13. Korea Workers' Compensation & Welfare Service. Guidelines on Raynaud's Syndrome: Guideline No. 2015-41. Ulsan, Korea: Korea Workers' Compensation & Welfare Service; 2015.
  14. Kim H. [Workers' Compensation and Welfare Corporation guidelines make workers cry] Raynaud's syndrome Industrial accident approval rate 'dropped' due to guidelines. Labortoday. https://www.labortoday.co.kr/news/articleView.html?idxno=140570. Updated 2016. Accessed March 20, 2022.
  15. Seoul High Court. Conviction 2018Nu30411 Judgment. Seoul, Korea: Administration of Seoul High Court; 2018.
  16. Seoul Administrative Court. Conviction 2019GuDan53467 Judgment. Seoul, Korea: Administration of Seoul High Court; 2020.
  17. Seoul High Court. Conviction 2016Nu66195 Judgment. Seoul, Korea: Administration of Seoul High Court; 2017.
  18. Pyykko I, Farkkila M, Korhonen O, Starck J, Jantti V. Cold provocation tests in the evaluation of vibration-induced white finger. Scand J Work Environ Health 1986;12(4 Spec No):254-8.  https://doi.org/10.5271/sjweh.2142
  19. Olsen N. Diagnostic tests in Raynaud's phenomena in workers exposed to vibration: a comparative study. Br J Ind Med 1988;45(6):426-30.  https://doi.org/10.1136/oem.45.6.426
  20. Pyykko I, Korhonen O, Farkkila M, Starck J, Aatola S. A longitudinal study of the vibration syndrome in Finnish forestry workers. In: Brammer AJ, Taylor W, editors. Vibration Effects on the Hand and Arm in Industry. 1982, 157-67.
  21. Hellstrom B, Myhre K. A comparison of some methods of diagnosing Raynaud phenomena of occupational origin. Br J Ind Med 1971;28(3):272-9.  https://doi.org/10.1136/oem.28.3.272
  22. Kylin B. Halso-och Miljoundersokning Bland Skogsarbetare: AI-rapport No. 5. Stockholm, Sweden: Arbetsmedicinska Instituttet; 1968, 44-52.
  23. Agate JN. An outbreak of cases of Raynaud's phenomenon of occupational origin. Br J Ind Med 1949;6(3):144-63.  https://doi.org/10.1136/oem.6.3.144
  24. Dinsdale G, Manning J, Herrick A, Dickinson M, Taylor C. O15 Using a smartphone app to characterise and quantify skin colour changes in Raynaud's attacks. Rheumatology 2021;60(Suppl 1):keab246.014.
  25. Poole CJ, Bovenzi M, Nilsson T, Lawson IJ, House R, Thompson A, et al. International consensus criteria for diagnosing and staging hand-arm vibration syndrome. Int Arch Occup Environ Health 2019;92(1):117-27.  https://doi.org/10.1007/s00420-018-1359-7
  26. Ye Y, Griffin MJ. Assessment of two alternative standardised tests for the vascular component of the handarm vibration syndrome (HAVS). Occup Environ Med 2016;73(10):701-8.  https://doi.org/10.1136/oemed-2016-103688
  27. Bovenzi M. Finger systolic blood pressure indices for the diagnosis of vibration-induced white finger. Int Arch Occup Environ Health 2002;75(1-2):20-8.  https://doi.org/10.1007/s004200100274
  28. Jennings JR, Maricq HR, Canner J, Thompson B, Freedman RR, Wise R, et al. A thermal vascular test for distinguishing between patients with Raynaud's phenomenon and healthy controls. Health Psychol 1999;18(4):421-6.  https://doi.org/10.1037//0278-6133.18.4.421
  29. Bovenzi M. Vibration-induced white finger and cold response of digital arterial vessels in occupational groups with various patterns of exposure to hand-transmitted vibration. Scand J Work Environ Health 1998;24(2):138-44.  https://doi.org/10.5271/sjweh.291
  30. Olsen N. Finger systolic blood pressure during cooling in VWF; value of different diagnostic categories for a routine test method. Eighth International Conference on Hand-Arm Vibration; 9-12 June 1998; Umea, Sweden. 1998, 19.
  31. Bovenzi M. Digital arterial responsiveness to cold in healthy men, vibration white finger and primary Raynaud's phenomenon. Scand J Work Environ Health 1993;19(4):271-6.  https://doi.org/10.5271/sjweh.1474
  32. Allen JA, Doherty CC, McGrann S. Objective testing for vasospasm in the hand-arm vibration syndrome. Br J Ind Med 1992;49(10):688-93.  https://doi.org/10.1136/oem.49.10.688
  33. Virokannas H, Rintamaki H. Finger blood pressure and rewarming rate for screening and diagnosis of Raynaud's phenomenon in workers exposed to vibration. Br J Ind Med 1991;48(7):480-4.  https://doi.org/10.1136/oem.48.7.480
  34. Kurozawa Y, Nasu Y, Nose T. Diagnostic value of finger systolic blood pressure in the assessment of vasospastic reactions in the finger skin of vibration-exposed subjects after finger and body cooling. Scand J Work Environ Health 1991;17(3):184-9.  https://doi.org/10.5271/sjweh.1712
  35. Bovenzi M. Finger systolic pressure during local cooling in normal subjects aged 20 to 60 years: reference values for the assessment of digital vasospasm in Raynaud's phenomenon of occupational origin. Int Arch Occup Environ Health 1988;61(3):179-81.  https://doi.org/10.1007/BF00381016
  36. Bovenzi M. Finger thermometry in the assessment of subjects with vibration-induced white finger. Scand J Work Environ Health 1987;13(4):348-51.  https://doi.org/10.5271/sjweh.2044
  37. Ekenvall L, Lindblad LE. Vibration white finger and digital systolic pressure during cooling. Br J Ind Med 1986;43(4):280-3.  https://doi.org/10.1136/oem.43.4.280
  38. Olsen N, Nielsen SL, Voss P. Cold response of digital arteries in chain saw operators. Br J Ind Med 1982;39(1):82-8.  https://doi.org/10.1136/oem.39.1.82
  39. Olsen N, Nielsen SL. Diagnosis of Raynaud's phenomenon in quarrymen's traumatic vasospastic disease. Scand J Work Environ Health 1979;5(3):249-56.  https://doi.org/10.5271/sjweh.3098
  40. Xiao B, Zhang D, Yan M, Qu H, Wen W, Zhang X, et al. Cold water immersion test (10 ℃, 10 min) for diagnosing vibration-induced white finger among a group of polishers in a subtropical environment. Int Arch Occup Environ Health 2019;92(6):865-72.  https://doi.org/10.1007/s00420-019-01425-4
  41. Mirbod SM, Sugiura H. A non-invasive technique for the evaluation of peripheral circulatory functions in female subjects with Raynaud's phenomenon. Ind Health 2017;55(3):275-84.  https://doi.org/10.2486/indhealth.2016-0201
  42. Mahbub MH, Ishitake T, Kurozawa Y, Toibana N, Ide F, Ohnari H, et al. Diagnostic performance of cold provocation test with hands immersion in water at 10℃ for 5 min evaluated in vibration-induced white finger patients and matched controls. Int Arch Occup Environ Health 2011;84(7):805-11.  https://doi.org/10.1007/s00420-011-0612-0
  43. Poole K, Elms J, Mason H. Cold-provocation testing for the vascular component of hand-arm vibration syndrome in health surveillance. Ind Health 2006;44(4):577-83.  https://doi.org/10.2486/indhealth.44.577
  44. Poole K, Elms J, Mason HJ. The diagnostic value of finger systolic blood pressure and cold-provocation testing for the vascular component of hand-arm vibration syndrome in health surveillance. Occup Med (Lond) 2004;54(8):520-7.  https://doi.org/10.1093/occmed/kqh108
  45. Mason HJ, Poole K, Saxton J. A critique of a UK standardized test of finger rewarming after cold provocation in the diagnosis and staging of hand-arm vibration syndrome. Occup Med (Lond) 2003;53(5):325-30.  https://doi.org/10.1093/occmed/kqg096
  46. Coughlin PA, Chetter IC, Kent PJ, Kester RC. The analysis of sensitivity, specificity, positive predictive value and negative predictive value of cold provocation thermography in the objective diagnosis of the hand-arm vibration syndrome. Occup Med (Lond) 2001;51(2):75-80.  https://doi.org/10.1093/occmed/51.2.075
  47. Bogadi-Sare A, Zavalic M. Diagnostic value of finger thermometry and photoplethysmography in the assessment of hand-arm vibration syndrome. Int Arch Occup Environ Health 1994;66(2):137-40.  https://doi.org/10.1007/BF00383370
  48. Harada N. Esthesiometry, nail compression and other function tests used in Japan for evaluating the hand-arm vibration syndrome. Scand J Work Environ Health 1987;13(4):330-3. https://doi.org/10.5271/sjweh.2032
  49. Laroche GP, Theriault G. Validity of plethysmography and the digital temperature recovery test in the diagnosis of primary and occupational Raynaud's phenomenon. Clin Invest Med 1987;10(2):96-102. 
  50. Pelmear PL, Roos J, Leong D, Wong L. Cold provocation test results from a 1985 survey of hard-rock miners in Ontario. Scand J Work Environ Health 1987;13(4):343-7.  https://doi.org/10.5271/sjweh.2030
  51. Kurumatani N, Iki M, Hirata K, Moriyama T, Satoh M, Arai T. Usefulness of fingertip skin temperature for examining peripheral circulatory disturbances of vibrating tool operators. Scand J Work Environ Health 1986;12(4 Spec No):245-8.  https://doi.org/10.5271/sjweh.2143
  52. Lim MJ, Kwon SR, Jung KH, Joo K, Park SG, Park W. Digital thermography of the fingers and toes in Raynaud's phenomenon. J Korean Med Sci 2014;29(4):502-6.  https://doi.org/10.3346/jkms.2014.29.4.502
  53. Lee JW, Jeong WS, Lee SM, Kim J. Comparison of the diagnostic performances of two protocols of hand perfusion scintigraphy for Raynaud's phenomenon. Nucl Med Commun 2012;33(10):1032-8.  https://doi.org/10.1097/MNM.0b013e3283567492
  54. Kwon SR, Lim MJ, Park SG, Hyun IY, Park W. Diagnosis of Raynaud's phenomenon by (99m)Tc-hydroxymethylene diphosphonate digital blood flow scintigraphy after one-hand chilling. J Rheumatol 2009;36(8):1663-70.  https://doi.org/10.3899/jrheum.080988
  55. Sarikaya A, Ege T, Firat MF, Duran E. Assessment of digital ischaemia and evaluation of response to therapy by 99mTc sestamibi limb scintigraphy after local cooling of the hands in patients with vasospastic Raynaud's syndrome. Nucl Med Commun 2004;25(2):207-11.  https://doi.org/10.1097/00006231-200402000-00019
  56. Pavlov-Dolijanovic S, Petrovic N, Vujasinovic Stupar N, Damjanov N, Radunovic G, Babic D, et al. Diagnosis of Raynaud's phenomenon by 99mTc-pertechnetate hand perfusion scintigraphy: a pilot study. Rheumatol Int 2016;36(12):1683-8.  https://doi.org/10.1007/s00296-016-3584-2
  57. Pavlov-Dolijanovic S, Petrovic N, Stupar NV, Damjanov N, Radunovic G, Radnic-Zivanovic T, et al. Diagnosis of Raynaud's Phenomenon by 99mTc-Pertechnetate Hand Perfusion Scintigraphy: A Pilot Study. London, UK: BMJ Publishing Group Ltd; 2015.
  58. Lee KA, Chung HW, Lee SH, Kim HR. The use of hand perfusion scintigraphy to assess Raynaud's phenomenon associated with hand-arm vibration syndrome. Clin Exp Rheumatol 2017;35(4 Suppl 106):138-43. 
  59. Chong A, Ha JM, Song HC, Kim J, Choi SJ. Conversion to paradoxical finding on technetium-99-mlabeled RBC scintigraphy after treatment for secondary Raynaud's phenomenon. Nucl Med Mol Imaging 2013;47(4):278-80.  https://doi.org/10.1007/s13139-013-0215-7
  60. Csiki Z, Galuska L, Garai I, Szabo N, Varga J, Andras C, et al. Raynaud's syndrome: comparison of late and early onset forms using hand perfusion scintigraphy. Rheumatol Int 2006;26(11):1014-8.  https://doi.org/10.1007/s00296-006-0121-8
  61. Galuska L, Garai I, Csiki Z, Varga J, Bodolay E, Bajnok L. The clinical usefulness of the fingers-to-palm ratio in different hand microcirculatory abnormalities. Nucl Med Commun 2000;21(7):659-63.  https://doi.org/10.1097/00006231-200007000-00010
  62. Bang SH, Oh YS, Park HJ, Lee TK, Yang JS, Lee SM, et al. Evaluation of finger blood flow with Tc-99m MDP (methylene diphosphonate). Korean J Intern Med 1992;7(2):94-101.  https://doi.org/10.3904/kjim.1992.7.2.94
  63. Kunnen JJ, Dahler HP, Doorenspleet JG, van Oene JC. Effects of intra-arterial ketanserin in Raynaud's phenomenon assessed by 99MTc-pertechnetate scintigraphy. Eur J Clin Pharmacol 1988;34(3):267-71.  https://doi.org/10.1007/BF00540954
  64. Herrick AL. Pathogenesis of Raynaud's phenomenon. Rheumatology (Oxford) 2005;44(5):587-96.  https://doi.org/10.1093/rheumatology/keh552
  65. Takeuchi T, Futatsuka M, Imanishi H, Yamada S. Pathological changes observed in the finger biopsy of patients with vibration-induced white finger. Scand J Work Environ Health 1986;12(4 Spec No):280-3.  https://doi.org/10.5271/sjweh.2140
  66. Sauni R, Paakkonen R, Virtema P, Toppila E, Uitti J. Dose-response relationship between exposure to hand-arm vibration and health effects among metalworkers. Ann Occup Hyg 2009;53(1):55-62.
  67. Kim K, Kim J. A work-relatedness assessment in epidemiological case investigation of occupational cancers: I. Principles. Ann Occup Environ Med 2020;32(1):e30. 
  68. Violante FS. Criteria for diagnosis and attribution of an occupational musculoskeletal disease. Med Lav 2020;111(4):249-68. 
  69. Cooke R. The Lewis-Prusik test. Time to Say Goodbye to an Old Friend? Oxford, UK: Oxford University Press; 2014, 312-3.
  70. Proud G, Burke F, Lawson IJ, McGeoch KL, Miles JN; Trade MRPotDo. Cold provocation testing and hand-arm vibration syndrome-an audit of the results of the Department of Trade and Industry scheme for the evaluation of miners. Br J Surg 2003;90(9):1076-9.  https://doi.org/10.1002/bjs.4200
  71. OECD.Stat. Health care resources. Medical technology. https://stats.oecd.org/Index.aspx?DataSetCode=HEALTH_REAC. Updated 2021. Accessed June 16, 2022.
  72. The Korean Society of Nuclear Medicine. Nuclear medicine statistics. https://www.ksnm.or.kr/. Updated 2021. Accessed June 16, 2022.
  73. Park N, Park M, Woo Y. Health and Welfare Statistical Year Book 2020. Wonju, Korea: National Health Insurance Service; 2020, 1-669.
  74. Gayraud M. Raynaud's phenomenon. Joint Bone Spine 2007;74(1):e1-8.  https://doi.org/10.1016/j.jbspin.2006.07.002
  75. Bouhoutsos J, Morris T, Martin P. Unilateral Raynaud's phenomenon in the hand and its significance. Surgery 1977;82(5):547-51. 
  76. Yoon JK, Sim CS, Oh MS, Sung JH, Lee JH, Lee CR, et al. The general characteristics and results of the cold provocation test in the risk group of HAVS. Korean J Occup Environ Med 2012;24(3):207-16. https://doi.org/10.35371/kjoem.2012.24.3.207