The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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Effects of Paeoniae Radix, Glycyrrhiza Uralensis and Jakyakgamcho-tang Treatment on Ulcerative Colitis Animal Model: Including Changes in Metabolites

작약, 감초 및 작약감초탕의 투여가 궤양성 대장염 동물 모델에 미치는 영향: 대사산물 변화를 포함하여

  • Choi, Sun Hee (Haneulche Korean Medicine Clinic) ;
  • Park, Eun Jung (Department of Pediatric, College of Korean Medicine, Wonkwang University)
  • 최선희 (하늘체한의원) ;
  • 박은정 (원광대학교 한의과대학 소아과학교실)
  • Received : 2022.07.27
  • Accepted : 2022.08.29
  • Published : 2022.08.31
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Abstract

Objectives To investigate the effect of Jakyakgamcho-tang (JGT) on Dextran sulfate sodium (DSS) induced ulcerative colitis. Methods Experimental animals were divided into six groups; group 1, normal group; group 2, DSS-induced colitis group; group 3, 5-aminosalicylic acid (5-ASA)-treated group; group 4, Glycyrrhiza Uralensis (Gamcho, GC)-treated group; group 5, Paeoniae Radix (Jakyak, JY)-treated group; group 6, JGT-treated group. Inflammatory cytokines and their metabolites were detected. Result In the JGT group, the levels of tumor necrosis factor alpha (TNF-α), prostaglandin E2 (PGE2) were significantly decreased, whereas that of Interleukin-10 (IL-10) were significantly increased. In addition, the metabolite profile changed in the JGT group with most metabolites increasing. Conclusion This study demonstrates that the therapeutic potential of JGT in ulcerative colitis. Further studies should be conducted to confirm our findings.

Keywords

Acknowledgement

본 연구는 2021학년도 원광대학교 교비지원에 의해 수행됨.

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