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Klebsiella pneumoniae and Enterobacter cloacae Induced Septic Arthritis in a Healthy Adolescent: A Rare Case Report

  • Reza Zandi (Department of Orthopedic Surgery, Taleghani Hospital Research Development Committee, School of Medicine, Shahid Beheshti University of Medical Sciences) ;
  • Shahin Talebi (Department of Orthopedic Surgery, Taleghani Hospital Research Development Committee, School of Medicine, Shahid Beheshti University of Medical Sciences) ;
  • Shirin Sheibani (Student Research Committee, School of Medicine, Mazandaran University of Medical Science) ;
  • Akbar Ehsani (Department of Orthopedic Surgery, Taleghani Hospital Research Development Committee, School of Medicine, Shahid Beheshti University of Medical Sciences)
  • Received : 2022.03.21
  • Accepted : 2022.05.26
  • Published : 2022.09.30

Abstract

Septic arthritis (SA) is a joint inflammation that develops secondary to infectious causes. SA in children is associated with a high rate of morbidity and mortality; therefore, it is regarded as an orthopedic emergency. Because SA of the hip joint usually mimics other musculoskeletal diseases, diagnosis remains challenging. Although this lesion usually shows a good outcome, treatment at an inappropriate time, neglect, or inadequate treatment could lead to poor outcomes. We report on the case of a healthy adolescent who complained of episodes of fever and chills, weight loss, pain in his left hip, and limping. After performing necessary workups, two differential diagnoses of tumor and SA were made. The results of Gram stain and culture of the synovial fluid after surgical excision showed Klebsiella pneumoniae and Enterobacter cloacae complex. To the best of our knowledge, this is the first report of SA due to co-infection with K. pneumoniae and E. cloacae in a healthy patient.

Keywords

Acknowledgement

Written informed consent was obtained from the patient's legal guardian for publication of their anonymized information in this article.

References

  1. Nade S. Septic arthritis. Best Pract Res Clin Rheumatol. 2003;17:183-200. https://doi.org/10.1016/s1521-6942(02)00106-7 
  2. Cohen E, Katz T, Rahamim E, Bulkowstein S, Weisel Y, Leibovitz R, et al. Septic arthritis in children: updated epidemiologic, microbiologic, clinical and therapeutic correlations. Pediatr Neonatol. 2020;61:325-30. https://doi.org/10.1016/j.pedneo.2020.02.006 
  3. Momodu II, Savaliya V. Septic arthritis. Treasure Island (FL): StatPearls Publishing LLC.; 2022. 
  4. Agarwal A, Aggarwal AN. Bone and joint infections in children: septic arthritis. Indian J Pediatr. 2016;83:825-33. https://doi.org/10.1007/s12098-015-1816-1 
  5. Swarup I, LaValva S, Shah R, Sankar WN. Septic arthritis of the hip in children: a critical analysis review. JBJS Rev. 2020;8:e0103. https://doi.org/10.2106/JBJS.RVW.19.00103 
  6. Moon JB, Lee JH, Ryu BJ. Septic arthritis of the hip joint caused by Klebsiella pneumoniae: a case report. J Yeungnam Med Sci. Published online January 13, 2022; https://doi.org/10.12701/yujm.2021.01613 
  7. Chee YC, Lim CH. Klebsiella pneumoniae sacroiliac septic arthritis: first case report. IDCases. 2018;14:e00459. https://doi.org/10.1016/j.idcr.2018.e00459 
  8. Huang J, Xu Q, Liu F, Xiong H, Yang J. Enterobacter cloacae infection of the shoulder in a 52-year-old woman without apparent predisposing risk factor: a case report and literature review. BMC Infect Dis. 2021;21:13. https://doi.org/10.1186/s12879-020-05699-9 
  9. de Groot R, Glover D, Clausen C, Smith AL, Wilson CB. Bone and joint infections caused by Kingella kingae: six cases and review of the literature. Rev Infect Dis. 1988;10:998-1004. https://doi.org/10.1093/clinids/10.5.998 
  10. Obletz BE. Acute suppurative arthritis of the hip in the neonatal period. J Bone Joint Surg Am. 1960;42-A:23-30. 
  11. Luhmann JD, Luhmann SJ. Etiology of septic arthritis in children: an update for the 1990s. Pediatr Emerg Care. 1999;15:40-2. https://doi.org/10.1097/00006565-199902000-00012 
  12. Kohen DP. Neonatal gonococcal arthritis: three cases and review of the literature. Pediatrics. 1974;53:436-40. https://doi.org/10.1542/peds.53.3.436 
  13. Montgomery NI, Epps HR. Pediatric septic arthritis. Orthop Clin North Am. 2017;48:209-16. https://doi.org/10.1016/j.ocl.2016.12.008 
  14. Wall C, Donnan L. Septic arthritis in children. Aust Fam Physician. 2015;44:213-5. 
  15. Bloem JL, Reidsma II. Bone and soft tissue tumors of hip and pelvis. Eur J Radiol. 2012;81:3793-801. https://doi.org/10.1016/j.ejrad.2011.03.101 
  16. Garcia-Arias M, Balsa A, Mola EM. Septic arthritis. Best Pract Res Clin Rheumatol. 2011;25:407-21. https://doi.org/10.1016/j.berh.2011.02.001 
  17. Lavy CB, Peek AC, Manjolo G. The incidence of septic arthritis in Malawian children. Int Orthop. 2005;29:195-6. https://doi.org/10.1007/s00264-005-0643-9 
  18. Gafur OA, Copley LA, Hollmig ST, Browne RH, Thornton LA, Crawford SE. The impact of the current epidemiology of pediatric musculoskeletal infection on evaluation and treatment guidelines. J Pediatr Orthop. 2008;28:777-85. https://doi.org/10.1097/BPO.0b013e318186eb4b 
  19. Lee HC, Chuang YC, Yu WL, et al. Clinical implications of hypermucoviscosity phenotype in Klebsiella pneumoniae isolates: association with invasive syndrome in patients with community-acquired bacteraemia. J Intern Med. 2006;259:606-14. https://doi.org/10.1111/j.1365-2796.2006.01641.x 
  20. Sanders WE Jr, Sanders CC. Enterobacter spp.: pathogens poised to flourish at the turn of the century. Clin Microbiol Rev. 1997;10:220-41. https://doi.org/10.1128/CMR.10.2.220 
  21. Mooney JF 3rd, Murphy RF. Septic arthritis of the pediatric hip: update on diagnosis and treatment. Curr Opin Pediatr. 2019;31:79-85. https://doi.org/10.1097/MOP.0000000000000703 
  22. Peltola H, Kallio MJ, Unkila-Kallio L. Reduced incidence of septic arthritis in children by Haemophilus influenzae type-b vaccination. Implications for treatment. J Bone Joint Surg Br. 1998;80:471-3. https://doi.org/10.1302/0301-620x.80b3.8296 
  23. Sanpera I, Raluy-Collado D, Sanpera-Iglesias J. Arthroscopy for hip septic arthritis in children. Orthop Traumatol Surg Res. 2016;102:87-9. https://doi.org/10.1016/j.otsr.2015.10.008 
  24. Thompson RM, Gourineni P. Arthroscopic treatment of septic arthritis in very young children. J Pediatr Orthop. 2017;37:e53-7. https://doi.org/10.1097/BPO.0000000000000659 
  25. El-Sayed AM. Treatment of early septic arthritis of the hip in children: comparison of results of open arthrotomy versus arthroscopic drainage. J Child Orthop. 2008;2:229-37. https://doi.org/10.1007/s11832-008-0094-0 
  26. Samora JB, Klingele K. Septic arthritis of the neonatal hip: acute management and late reconstruction. J Am Acad Orthop Surg. 2013;21:632-41. https://doi.org/10.5435/JAAOS-21-10-632