Toxicological Research

  • 제38권2호
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  • Pages.187-194
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  • 2022
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지
DOI QR코드

DOI QR Code

Sub-lethal effects of organophosphates and synthetic pyrethroid insecticides on muscle tissue transaminases of Oreochromis niloticus in vivo

  • Amin, Muhammad (Department of Zoology, University of Karachi) ;
  • Yousuf, Masarrat (Department of Zoology, University of Karachi) ;
  • Ahmad, Naveed (Department of Maritime Science, Bahria University) ;
  • Attaullah, Mohammad (Department of Zoology, University of Malakand) ;
  • Ikram, Muhammad (Department of Chemistry, Abdul Wali Khan University) ;
  • Zaid, Attia A. Abou (Department of Aquaculture, Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University) ;
  • Yaro, Clement Ameh (Department of Animal and Environmental Biology, University of Uyo) ;
  • Alshammari, Eida M. (Department of Chemistry, College of Sciences, University of Ha'il) ;
  • Binnaser, Yaser S. (Department of Biology, College of Sciences, Taibah University) ;
  • Batiha, Gaber El‑Saber (Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicines, Damanhour University) ;
  • Buneri, Islam Dad (Department of Zoology, University of Karachi)
  • 투고 : 2020.12.05
  • 심사 : 2021.04.20
  • 발행 : 2022.04.15
⟨ 이전 논문 다음 논문 ⟩

초록

Organophosphates and synthetic pyrethroid insecticides have been commonly used in public health and agriculture. The present study aimed to evaluate the sub-lethal effects of organophosphates and synthetic pyrethroid insecticides on transaminases: glutamate oxaloacetate/aspartate transaminase (AST) and glutamate pyruvate/alanine transaminase (ALT) in Oreochromis niloticus. Fish were exposed to malathion (OP), chlorpyrifos (OP) and λ-cyhalothrin (synthetic pyrethroid) at sublethal concentrations of 1.425, 0.125 and 0.0039 ppm, respectively for 24 and 48 h. AST and ALT activities were shown to be remarkably (p<0.05) decreased and increased, respectively in O. niloticus treated with the insecticides. The highest and lowest inhibition in AST level were noted as -12.2% and -12.2% in chlorpyrifos and λ-cyhalothrin 24 h treated fish samples, respectively. The highest and lowest elevation in ALT level were recorded as+313% and 237% in 48 h chlorpyrifos and 24 h malathion treated fish samples, respectively. This indicates that the insecticides used in this study did not result in death but in changes in AST and ALT enzyme activities. Therefore, organophosphates (malathion, chlorpyrifos) and synthetic pyrethroid (λ-cyhalothrin) insecticides are toxic to fishes and could affects their survival in their natural habitat.

키워드

과제정보

The authors extend their appreciation to the Researchers supporting Project Number (RSP-2020/120) King Saud University, Riyadh, Saudi Arabia.

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