Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Ethanolic Extract of Pancake Mixture Powder Supplemented with Helianthus tuberosus Enhances Antidiabetic Effects via Inhibiting Inflammatory Mediator NO Production

  • Lee, Kyoung-Dong (Department of Oriental Medicine Materials, College of Oriental Medicine, Dongsin University) ;
  • Sun, Hyeon-Jin (Subtropical Horticulture Research Institute, Jeju National University) ;
  • Lee, Mina (College of Pharmacy, Sunchon National University) ;
  • Chun, Jiyeon (Department of Food Science and Technology, College of Life Science and Natural Resources, Sunchon National University) ;
  • Shin, Tai-Sun (Division of Food and Nutrition, Chonnam National University) ;
  • Choi, Kap Seong (Department of Food Science and Technology, College of Life Science and Natural Resources, Sunchon National University) ;
  • Shim, Sun-Yup (Department of Food Science and Technology, College of Life Science and Natural Resources, Sunchon National University)
  • Received : 2021.09.23
  • Accepted : 2022.02.03
  • Published : 2022.06.28
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Abstract

Helianthus tuberosus is perennial plant as Compositae family and is shown various physiological activities such as analgesic, antipyretic, anti-inflammatory, anti-fungal, anti-spasmodic, aperient, cholagogue, diuretic, spermatogenic, stomachic, and tonic effects. In this study, we investigated the antidiabetic and anti-inflammatory effects of pancake mixture powder (PM) supplemented with H. tuberosus (PMH) in rat skeletal muscle L6 cells and murine macrophage RAW 264.7 cells, respectively. PM and PMH inhibited in vitro α-glucosidase activity. Glucose consumption was increased by PM and PMH without cytotoxicity in rat myoblast L6 cells. Western blot analysis revealed that PM and PMH down-regulated glycogen synthase kinase (GSK)-3β activation in L6 cells. PM and PMH inhibited inflammatory mediator, nitric oxide (NO) production without cytotoxicity in LPS-induced RAW 264.7 cells. The anti-diabetic and anti-inflammatory effects of PMH was more stronger than those of PM. Anti-diabetic and anti-inflammatory effects of PMH would be due to functional characteristics of the supplemented H. tuberosus and the presence of garlic and onion used as ingredients of PM. Taken together, our results that addition of functional materials such as H. tuberosus in product has synergic effects and PMH is potential candidate for treatment of diabetes through inhibiting inflammation.

Keywords

References

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