Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Analgesic Effect of Poria cocos Extract on a Rat Model of Adjuvant-induced Arthritis

  • Lee, Gil-Hyun (Department of Clinical Laboratory Science, Wonkwang Health Science University) ;
  • Yoon, Hae-Gyung (Division of Basic Science, Dong-Eui University) ;
  • Choi, Go-Eun (Department of Clinical Laboratory Science, Catholic University of Pusan) ;
  • Hyun, Kyung-Yae (Department of Clinical Laboratory Science, Dong-Eui University)
  • Received : 2022.05.23
  • Accepted : 2022.06.22
  • Published : 2022.06.30
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Abstract

Poria cocos is a natural substance known to have anticancer, antioxidant and anti-inflammatory effects. The aim of this study is to investigate the analgesic effects of Poria cocos extract (PCE). We evaluated the analgesic effects of PCE using adjuvant induced arthritis rat model. Male SD rats were administered intra-orally with PCE according to prescribed dosage, during 6 days. After 6 days later, serum TNF-α, IL-1β, and IL-6 levels were measured by ELISA. In our experiment, administration of PCE decreased TNF-α, IL-1β, IL-6 and PGE2 level in serum. Furthermore, it was confirmed that allodynia was relieved in evaluation of pain behavior. It was confirmed that administration of PCE reduces nociceptive pain by reducing nociceptive stimuli by acting as an anti-inflammatory drug.

Keywords

Acknowledgement

This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-2019S1A5C2A04081101).

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