Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Integrated Hybrid Device for High-Efficiency Size-Tunable Particle Separation

고효율 크기 가변적 입자 분리를 위한 통합 하이브리드 소자

  • Choo, Seung Hee (College of Life Sciences and Bio engineering, Incheon National University) ;
  • Park, Jion (Department of Song-do Bio Engineering, Incheon Jaeneung University) ;
  • Kim, Tae Eun (Artificial Intelligent-Bio Research Center, Incheon Jaeneung University) ;
  • Gang, Tae Gyeoung (Department of Song-do Bio Engineering, Incheon Jaeneung University) ;
  • An, Jun Seok (Department of Song-do Bio Engineering, Incheon Jaeneung University) ;
  • Oh, Gayeong (Department of Song-do Bio Engineering, Incheon Jaeneung University) ;
  • Kim, Yeojin (Department of Song-Do Bio Life Engineering, Incheon Jaeneung University) ;
  • Park, Kyu Been (Department of Song-Do Bio Life Engineering, Incheon Jaeneung University) ;
  • Park, Chaewon (Department of Song-Do Bio Life Engineering, Incheon Jaeneung University) ;
  • Lee, Minjeong (Department of Song-Do Bio Life Engineering, Incheon Jaeneung University) ;
  • Lim, Hyunjung (Artificial Intelligent-Bio Research Center, Incheon Jaeneung University) ;
  • Nam, Jeonghun (Department of Song-do Bio Engineering, Incheon Jaeneung University)
  • 추승희 (인천대학교 생명공학부 나노바이오전공) ;
  • 박지온 (인천재능대학교 송도바이오과) ;
  • 김태은 (인천재능대학교 인공지능바이오연구소) ;
  • 강태경 (인천재능대학교 송도바이오과) ;
  • 안준석 (인천재능대학교 송도바이오과) ;
  • 오가영 (인천재능대학교 송도바이오과) ;
  • 김여진 (인천재능대학교 송도바이오생명과) ;
  • 박규빈 (인천재능대학교 송도바이오생명과) ;
  • 박채원 (인천재능대학교 송도바이오생명과) ;
  • 이민정 (인천재능대학교 송도바이오생명과) ;
  • 임현정 (인천재능대학교 인공지능바이오연구소) ;
  • 남정훈 (인천재능대학교 송도바이오과)
  • Received : 2022.06.07
  • Accepted : 2022.06.13
  • Published : 2022.06.30
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Abstract

Cell separation from a heterogenous mixture sample is an essential process for downstream analysis in biological, chemical, and clinical applications. This study demonstrates an integrated hybrid device of the viscoelastic focusing in a straight rectangular channel and subsequent size-based separation using acoustophoresis to attain high efficiency and separation tunability. For particle pre-alignment in a viscoelastic fluid, the flow rate higher than 10 μl/min was required. Surface acoustic wave-based lateral migration of particles with different sizes (13 and 27 ㎛) was examined at various applied voltages and flow rate conditions. Therefore, the flow rate of 100 μl/min and the applied voltage of 20 Vpp can be used for size-based particle separation.

Keywords

Acknowledgement

이 논문은(는) 2022년도 정부(과학기술정보통신부)의 재원으로 한국연구재단의 지원을 받아 수행된 연구임(No. 2020R1A2C1014460).

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