Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Eriodictyol induces apoptosis via regulating phosphorylation of JNK, ERK, and FAK/AKT in pancreatic cancer cells

  • Oh, Ui Hyeon (Faculty of Biotechnology, College of Applied Life Science, SARI, Jeju National University) ;
  • Kim, Da-Hye (Faculty of Biotechnology, College of Applied Life Science, SARI, Jeju National University) ;
  • Lee, Jungwhoi (Subtropical/tropical organism gene bank, Jeju National University) ;
  • Han, Song-I (Subtropical/tropical organism gene bank, Jeju National University) ;
  • Kim, Jae-Hoon (Faculty of Biotechnology, College of Applied Life Science, SARI, Jeju National University)
  • Received : 2022.02.17
  • Accepted : 2022.03.23
  • Published : 2022.06.30
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Abstract

Although it has been intensively studied over the past few decades, pancreatic cancer remains one of the most lethal cancers. Eriodictyol, a plant-derived flavonoid mainly found in citrus fruits, exerts diverse biological effects, including anti-oxidant, anti-cancer, and anti-inflammatory properties. In this study, we investigated the anticancer properties of eriodictyol and its mechanisms of action in pancreatic cancer cells. In both SNU213 and Panc-1 cells, eriodictyol decreased viability, induced apoptosis, and decreased clonogenicity. In addition, eriodictyol treatment increased the phosphorylation level of JNK and decreased the phosphorylation levels of ERK, FAK, and AKT. These observations provide insight into the molecular mechanisms of eriodictyol-induced apoptosis in pancreatic cancer cell lines, and could contribute to the development of candidate compounds for treating pancreatic cancer.

Keywords

Acknowledgement

This research was supported by the 2021 scientific promotion program funded by Jeju National University.

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