Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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A New Dimeric Lignan from the Stems of Willughbeia edulis

  • Received : 2022.02.17
  • Accepted : 2022.05.13
  • Published : 2022.06.30
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Abstract

As part of our continued study on the chemical constituents of Willughbeia edulis stems, a new dimeric lignan named edulignan (1) was isolated from its EtOAc-soluble extract. Based on NMR spectroscopic interpretation, the planar structure of 1 has been suggested to have two 2-substituted 4-chromanone subunits with different stereochemical configurations. In addition, the MS/MS analysis of the products obtained by acid-catalyzed hydrolysis of 1 was supportive of its structure. Unfornatually, the new compound 1 did not show 𝛼-glucosidase inhibitory activity with an IC50 value > 250 𝜇M.

Keywords

Acknowledgement

This research is funded by Vietnam National University Ho Chi Minh City (VNU-HCM) under grant number NCM2020-18-01, to Mai Thanh Thi Nguyen.

References

  1. Wiart, C. Medicinal Plants of Asia and the Pacific; CRC Press: USA, 2006, pp 257-258.
  2. Dang, P. H.; Nguyen, H. X.; Nguyen, N. T.; Le, H. N. T.; Nguyen, M. T. T. Phytother. Res. 2014, 28, 1632-1636. https://doi.org/10.1002/ptr.5175
  3. Dang, P. H.; Nguyen, N. T.; Nguyen, H. X.; Nguyen, L. B.; Le, T. H.; Do, T. N. V.; Can, M. V.; Nguyen, M. T. T. Fitoterapia 2015, 100, 201-207. https://doi.org/10.1016/j.fitote.2014.12.004
  4. Nguyen, H. X.; Le, T. C.; Do, T. N. V.; Le, T. H.; Nguyen, N. T.; Nguyen, M. T. Chem. Cent. J. 2016, 10, 45. https://doi.org/10.1186/s13065-016-0193-9
  5. Dang, P. H.; Le, T. H.; Phan, P. K. T.; Le, P. T. T.; Nguyen, M. T. T.; Nguyen, N. T. Tetrahedron Lett. 2017, 58, 1553-1557. https://doi.org/10.1016/j.tetlet.2017.02.083
  6. Dang, P. H.; Nguyen, H. X.; Duong, T. T. T.; Tran, T. K. T.; Nguyen, P. T.; Vu, T. K. T.; Vuong, H. C.; Phan, N. H. T.; Nguyen, M. T. T.; Nguyen, N. T.; Awale, S. J. Nat. Prod. 2017, 80, 1087-1095. https://doi.org/10.1021/acs.jnatprod.7b00006
  7. Dang, P. H.; Nguyen, H. H. T.; Truong, H. T. T.; Do, T. N. V.; Nguyen, H. X.; Nguyen, M. T. T.; Abe, M.; Takagi, R.; Nguyen, N. T. Tetrahedron Lett. 2017, 58, 3897-3900. https://doi.org/10.1016/j.tetlet.2017.08.073
  8. Dang, P. H.; Nguyen, H. X.; Nguyen, H. H. T.; Vo, T. D.; Le, T. H.; Phan, T. H. N.; Nguyen, M. T. T.; Nguyen, N. T. J. Nat. Prod. 2017, 80, 1876-1882. https://doi.org/10.1021/acs.jnatprod.7b00171
  9. Nguyen, N. T.; Duong, T. T. T.; Dang, P. H.; Nguyen, H. X.; Le, T. H.; Do, T. N. V.; Le, T. D.; Tran, T. H.; Nguyen, M. T. T. Nat. Prod. Res. 2021, 2021, 1-8.
  10. Nguyen, N. T.; Tran, T. T. T.; Dang, P. H.; Le, T. H.; Nguyen, H. X.; Do, T. N. V.; Nguyen, M. T. T. Nat. Prod. Res. 2021, 2021, 1-5.
  11. Lam, L. T. M.; Dang, P. H.; Nguyen, H. X.; Nguyen, N. T.; Nguyen, M. T. T. Sci. Technol. Dev. J. Nat. Sci. 2017, 5, 137-142.
  12. Can, M. V.; Tran, A. H.; Pham, D. M.; Dinh, B. Q.; Le, Q. V.; Nguyen, B. V.; Nguyen, M. T. T.; Nguyen, H. X.; Nguyen, N. T.; Nishijo, H. J. Ethnopharmacol. 2018, 214, 99-105. https://doi.org/10.1016/j.jep.2017.06.035
  13. Okuyama, E.; Suzumura, K.; Yamazaki, M. Chem. Pharm. Bull. 1995, 43, 2200-2204. https://doi.org/10.1248/cpb.43.2200
  14. Raymakers, A.; Compernolle, F. Phytochemistry 1973, 12, 2287-2291. https://doi.org/10.1016/0031-9422(73)85136-2
  15. Kurihara, H.; Sasaki, M.; Hatano, M. Fish. Sci. 1994, 60, 759-761. https://doi.org/10.2331/fishsci.60.759