Journal of fish pathology (한국어병학회지)

The Korean Society of Fish Pathology (한국어병학회)
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Antiviral effects of various plant extracts against viral haemorrhagic septicaemia virus (VHSV)

바이러스성출혈성패혈증바이러스에 대한 식물 추출물의 항바이러스 효능 탐색

  • Park, Ji-Yoon (Department of Aquatic Life Medical Sciences, Sunmoon University) ;
  • Kim, Hyoung Jun (Pathology Research Division, National Institute of Fisheries Science) ;
  • Choi, Hye-Sung (Pathology Research Division, National Institute of Fisheries Science) ;
  • Kwon, Se Ryun (Department of Aquatic Life Medical Sciences, Sunmoon University)
  • 박지윤 (선문대학교 수산생명의학과) ;
  • 김형준 (국립수산과학원 병리연구과) ;
  • 최혜승 (국립수산과학원 병리연구과) ;
  • 권세련 (선문대학교 수산생명의학과)
  • Received : 2022.05.18
  • Accepted : 2022.05.31
  • Published : 2022.06.30
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Abstract

Since viral haemorrhagic septicaemia virus (VHSV) was first reported in European rainbow trout (Oncorhynchus mykiss) in the 1930s, it has caused high prices in freshwater and saltwater fish around the world, causing enormous economic damage to the aquaculture industry. We have been seeking required countermeasures against viruses because of economic damage to the aquaculture industry. However, commercial vaccines have the limitations of being costly to use in farms and being effective to only one pathogen. The aquaculture industry these days is taking on new alternatives to vaccines, antibiotics and chemicals. In this study, the suitability of antiviral effects against VHSV was evaluated in vitro for various plant extracts to judge their effectiveness. Atriplex gmelinii, Ixeris repens, Arctium lappa, and Sargassum coreanum were tested to know the correlation between the amount of virus and the concentration of extract investigates if these extracts have antiviral effects. Virus and extracts at various concentrations were inoculated simultaneously as 1:1 ratio into EPC cell lines. There are no antiviral effects with Atriplex gmelinii, Ixeris repens and Arctium lappa. Extract of Sargassum coreanum only has the antiviral activity in a dose-dependent manner. These results show that extract of Sargassum coreanum can be used in aquaculture industry as an antiviral materials.

Keywords

Acknowledgement

이 연구는 2022년 국립수산과학원 수산과학연구사업(R2022077, OIE 표준실험실 운영 및 관리)의 지원으로 수행되었습니다.

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