Nuclear Engineering and Technology

Korean Nuclear Society (한국원자력학회)
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Iodine-131 S values for use in organ dose estimation of Korean patients in radioiodine therapy

  • Yeom, Yeon Soo (Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) ;
  • Shin, Bangho (Department of Nuclear Engineering, Hanyang University) ;
  • Choi, Chansoo (Department of Nuclear Engineering, Hanyang University) ;
  • Han, Haegin (Department of Nuclear Engineering, Hanyang University) ;
  • Kim, Chan Hyeong (Department of Nuclear Engineering, Hanyang University)
  • Received : 2021.05.04
  • Accepted : 2021.08.23
  • Published : 2022.02.25
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Abstract

In the present study, iodine-131 S values (rT ← thyroid) were calculated for 30 target organs and tissues using the most recently developed Korean reference computational phantoms. The calculated S values were then compared with those of the International Commission on Radiological Protection (ICRP) reference computational phantoms to investigate the dosimetric impact of the Korean S values against those of the ICRP reference phantoms. The results showed significant differences in the S values due to the different anatomical/morphological characteristics between the Korean and ICRP reference phantoms. Most target organs/tissues showed that the S values of the Korean reference phantoms are lower than those of the ICRP reference phantoms, by up to about 4 times (male spleen and female thymus). Exceptionally, three target organs/tissues (gonads, thyroid, and extrathoracic region) showed that the S values of the Korean reference phantoms are greater, by 1.5-3.7 times. We expect that the S values calculated in the present study will be beneficially used to estimate organ/tissue doses of Korean patients under radioiodine therapy.

Keywords

Acknowledgement

This work was funded by the intramural program of the National Institutes of Health (NIH), National Cancer Institute, Division of Cancer Epidemiology and Genetics. This work was also supported by the Korea Institute of Energy Technology Evaluation and Planning (KETEP) grant funded by the Korea goverment (MOTIE) (Promoting of expert for energy industry advancement in the field of radiation technology, 20214000000070). The calculations in this work were performed on the NIH High-Performance Computing Biowulf Cluster (http://hpc.nih.gov).

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