대한영상의학회지 (Journal of the Korean Society of Radiology)

  • 제83권3호
  • /
  • Pages.527-537
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  • 2022
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  • 1738-2637(pISSN)
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  • 2288-2928(eISSN)
대한영상의학회 (The Korean Society of Radiology)
권호 표지
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노화 및 인지기능장애에서 뇌 철 영상 기법: 자기공명영상을 이용한 접근

Brain Iron Imaging in Aging and Cognitive Disorders: MRI Approaches

  • 장진희 (가톨릭대학교 의과대학 서울성모병원 영상의학과) ;
  • 강정화 (한국외국어대학교 바이오메디컬공학부) ;
  • 남윤호 (한국외국어대학교 바이오메디컬공학부)
  • Jinhee Jang (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Junghwa Kang (Division of Biomedical Engineering, Hankuk University of Foreign Studies) ;
  • Yoonho Nam (Division of Biomedical Engineering, Hankuk University of Foreign Studies)
  • 투고 : 2022.03.29
  • 심사 : 2022.05.16
  • 발행 : 2022.05.01
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초록

철은 중추신경계 및 인체에 필수적인 성분으로 노화 및 다양한 퇴행성 뇌질환에서 뇌의 철 침착이 증가된다. 철은 MRI에서 독특한 특성을 가지고 있어 인체의 철 침착과 분포를 비침 습적으로 평가 및 정량화가 가능하다. 이 종설에서는 철 영상을 위한 MRI 기법에 대하여 알아보고, 노화 및 알츠하이머병을 포함한 퇴행성 뇌질환에서 변화를 고찰해 보고자 한다. 또한 현재 접근법의 제한점과 앞으로 기대되는 새로운 접근도 확인해 보고자 한다.

Iron has a vital role in the human body, including the central nervous system. Increased deposition of iron in the brain has been reported in aging and important neurodegenerative diseases. Owing to the unique magnetic resonance properties of iron, MRI has great potential for in vivo assessment of iron deposition, distribution, and non-invasive quantification. In this paper, we will review the MRI methods for iron assessment and their changes in aging and neurodegenerative diseases, focusing on Alzheimer's disease. In addition, we will summarize the limitations of current approaches and introduce new areas and MRI methods for iron imaging that are expected in the future.

키워드

과제정보

This work was supported by National Research Foundation of Korea funded by the Korea government (MSIT) (NRF-2020R1C1C1012320) and Hankuk University of Foreign Studies Research Fund (20211238001).

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