대한영상의학회지 (Journal of the Korean Society of Radiology)

  • 제83권3호
  • /
  • Pages.508-526
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  • 2022
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  • 1738-2637(pISSN)
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  • 2288-2928(eISSN)
대한영상의학회 (The Korean Society of Radiology)
권호 표지
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파킨슨병의 자기공명영상 소견: 흑질선조체 변성의 영상학적 평가

MRI Findings in Parkinson's Disease: Radiologic Assessment of Nigrostriatal Degeneration

  • 배윤정 (서울대학교 의과대학 분당서울대학교병원 영상의학과) ;
  • 김종민 (서울대학교 의과대학 분당서울대학교병원 신경과) ;
  • 최병세 (서울대학교 의과대학 분당서울대학교병원 영상의학과) ;
  • 송요성 (서울대학교 의과대학 분당서울대학교병원 핵의학과) ;
  • 남윤호 (한국외국어대학교 바이오메디컬공학부) ;
  • 조세진 (서울대학교 의과대학 분당서울대학교병원 영상의학과) ;
  • 김재형 (서울대학교 의과대학 분당서울대학교병원 영상의학과) ;
  • 김상은 (서울대학교 의과대학 분당서울대학교병원 핵의학과)
  • Yun Jung Bae (Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Jong-Min Kim (Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Byung Se Choi (Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Yoo Sung Song (Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Yoonho Nam (Division of Biomedical Engineering, Hankuk University of Foreign Studies) ;
  • Se Jin Cho (Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Jae Hyoung Kim (Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine) ;
  • Sang Eun Kim (Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
  • 투고 : 2022.04.06
  • 심사 : 2022.05.12
  • 발행 : 2022.05.01
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초록

파킨슨병은 중뇌 흑질에 위치한 도파민성 신경세포의 퇴행성 소실로 인해 발생하는 이상운동질환이다. 최근 다양한 자기공명영상기법의 발전으로 파킨슨병에서 일어나는 병리생태학적인 변화를 반영하는 여러 영상 소견들이 보고되었다. 여러 연구에서 이러한 영상 소견들은 파킨슨병의 진단 및 비정형 파킨슨증과의 감별 등에 유의미한 도움을 줄 수 있는 것이 밝혀졌다. 본 종설에서는, 파킨슨병에서 일어나는 흑질선조체 변성의 병태생리를 나타낼 수 있는 나이그로좀 영상 및 뉴로멜라닌 영상 등을 포함한 자기공명영상기법들과 각 영상에서 나타나는 소견에 대하여 자세히 다루었다.

Parkinson's disease (PD) is a movement disorder that develops due to degenerative loss of dopaminergic cells in the substantia nigra of the midbrain. Recent advances in MRI techniques have demonstrated various imaging findings that can reflect the underlying pathophysiological processes occurring in Parkinson's disease. Many imaging studies have shown that such findings can assist in the diagnosis of Parkinson's disease and its differentiation from atypical parkinsonism. In this review, we present MRI techniques that can be used in clinical assessment, such as nigrosome imaging and neuromelanin imaging, and we provide the detailed imaging features of Parkinson's disease reflecting nigrostriatal degeneration.

키워드

과제정보

This study was supported by grant No. 02-2021-0015 from the Seoul National University Bundang Hospital Research Fund.

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