Journal of the Korean Magnetic Resonance Society (한국자기공명학회논문지)

Korean Magnetic Resonance Society (한국자기공명학회)
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High-pressure NMR application for α-synuclein

  • Kim, Jin Hae (Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST))
  • Received : 2022.06.18
  • Accepted : 2022.06.19
  • Published : 2022.06.20
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Abstract

High-pressure (HP) NMR is a powerful method to elucidate various structural features of amyloidogenic proteins. Following the previous mini-review recapitulating the HP-NMR application for amyloid-β peptides of the last issue [J. H. Kim, J. Kor. Mag. Reson. Soc. 26, 17 (2022)], the recent advancements in the HP NMR application for α-synuclein (α-Syn) are briefly summarized and discussed here. Although α-Syn is a well-known intrinsically disordered protein (IDP), several studies have shown that it can also exhibit heterogeneous yet partially folded conformations, which may correlate with its amyloid-forming propensity. HP NMR has been a valuable tool for investigating the dynamic and transient structural features of α-Syn and has provided unique insights to appreciate its aggregation-prone characters.

Keywords

Acknowledgement

This research was supported by the National Research Foundation (NRF) funded by the Ministry of Science & ICT (NRF-2020R1I1A2074335).

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