The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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A Case Report on Opioid-Induced Constipation in a Patient with Cancer Treated by Jowiseunggi-tang

조위승기탕으로 호전된 암 환자의 마약성 진통제로 인한 변비 치험 1례

  • Yoon, Jee-Hyun (Dept of Korean Internal Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Park, Su Bin (Dept of Korean Internal Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Kim, Eun Hye (Dept of Korean Internal Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Lee, Jee Young (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation) ;
  • Yoon, Seong Woo (Dept of Korean Internal Medicine, Kyung Hee University Hospital at Gangdong)
  • 윤지현 (강동경희대학교한방병원 한방내과) ;
  • 박수빈 (강동경희대학교한방병원 한방내과) ;
  • 김은혜 (강동경희대학교한방병원 한방내과) ;
  • 이지영 (자생의료재단 척추관절연구소) ;
  • 윤성우 (강동경희대학교한방병원 한방내과)
  • Received : 2022.04.07
  • Accepted : 2022.05.20
  • Published : 2022.05.30
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Abstract

Objective: Jowiseunggi-tang (JWSGT) is a traditional herbal medicine commonly used for purgative activity in constipation. This study evaluates JWSGT for the treatment of opioid-induced constipation (OIC), the most common and debilitating gastrointestinal effect of opioid use. Methods: A 64-year-old man with floor of mouth cancer was hospitalized for OIC, and JWSGT was administered orally twice a day for 10 days, along with acupuncture, moxibustion, and cupping. The primary outcome measures were defecation type according to the Bristol Stool Form Scale (BSFS) and the frequency of bowel movements. The Brief Fatigue Inventory (BFI) and the Functional Assessment of Cancer Therapy-General (FACT-G) were used as secondary measures. Results: After three days of JWSGT administration, spontaneous bowel movements were observed two to three times per week with improved BSFS from type 2 to 4. A reduction in BFI score (8.7 to 2.0) and an increase in FACT-G score (44.3 to 59.0) suggested an improvement in fatigue level and quality of life. Conclusion: This is the first report to assess the efficacy of JWSGT for the management of OIC in patients with cancer, and JWSGT may be an effective option to improve symptoms and quality of life in this group.

Keywords

Acknowledgement

본 연구는 보건복지부의 재원으로 한국보건산업진흥원의 보건의료기술연구개발사업 지원에 의하여 이루어진 것임(HF20C0038).

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