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협점막에서 발생한 MALT 림프종 1예

A Case of Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma in Buccal Mucosa

  • 이현아 (한양대학교 의과대학 이비인후-두경부외과학 교실) ;
  • 명재경 (한양대학교 의과대학 병리학교실) ;
  • 태경 (한양대학교 의과대학 이비인후-두경부외과학 교실)
  • Lee, Hyeon A (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University) ;
  • Myung, Jae Kyung (Department of Pathology, College of Medicine, Hanyang University) ;
  • Tae, Kyung (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University)
  • 투고 : 2021.10.12
  • 심사 : 2022.01.04
  • 발행 : 2022.05.30

초록

Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a low-grade B-cell lymphoma that typically follows an indolent clinical course. It occurs in a variety of mucosal linings extranodal tissue, most commonly in the stomach. Other commonly involved sites include other parts of the gastrointestinal tract, thyroid, salivary gland, lung, lacrimal gland, synovium, dura mater, breast, skin, and eyes. It occurs very rarely in the buccal mucosa. A 50-year-old man came to the clinic while presenting a 5-month history of right-sided buccal mass. The incisional biopsy did not confirm the diagnosis of the lesion. He underwent complete excision of buccal mass for the diagnosis and treatment. The final pathology confirmed MALT lymphoma immunohistochemically. After surgery, he received radiotherapy with 30.6 Gy. There is no recurrence for 8 months after treatment. Herein we report a rare case of buccal MALT lymphoma with a review of the literature.

키워드

참고문헌

  1. Hanna E, Wanamaker J, Adelstein D, Tubbs R, Lavertu P. Extranodal lymphomas of the head and neck. A 20-year experience. Arch Otolaryngol Head Neck Surg. 1997;123:1318-1323. https://doi.org/10.1001/archotol.1997.01900120068011
  2. Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES. The 2008 WHO classification of lymphoid neoplasms and beyond: Evolving concepts and practical applications. Blood. 2011;117:5019-5032. https://doi.org/10.1182/blood-2011-01-293050
  3. Isaacson PG, Spencer J. Malignant lymphoma of mucosa-associated lymphoid tissue. Histopathology. 1987;11:445-462. https://doi.org/10.1111/j.1365-2559.1987.tb02654.x
  4. Thieblemont C, Bastion Y, Berger F, Rieux C, Salles G, Dumontet C, et al. Mucosa-associated lymphoid tissue gastrointestinal and nongastrointestinal lymphoma behavior: Analysis of 108 patients. J Clin Oncol. 1997;15:1624-1630. https://doi.org/10.1200/JCO.1997.15.4.1624
  5. Silva TD, Ferreira CB, Leite GB, de Menezes Pontes JR, Antunes HS. Oral manifestations of lymphoma: A systematic review. Ecancermedicalscience. 2016;10:665.
  6. Yoon DG, Jin SY, Kim HJ, Kim CD. A case of non-Hodgkins lymphoma of the oral cavity presenting as a buccal mass. Korean J Otorhinolaryngol Head Neck Surg. 2003;46:528-531.
  7. Kwak SG, Baek HH, Kim YJ, Kim SW. A case of MALT lymphoma of buccal area. Korean J Otorhinolaryngol Head Neck Surg. 2015;58:287-289. https://doi.org/10.3342/kjorl-hns.2015.58.4.287
  8. Jacobs C, Hoppe RT. Non-Hodgkin's lymphomas of head and neck extranodal sites. Int J Radiat Oncol Biol Phys. 1984;11:357-364. https://doi.org/10.1016/0360-3016(85)90158-0
  9. Epstein JB, Epstein JD, Le ND, Gorsky M. Characteristics of oral and paraoral malignant lymphoma: A population-based review of 361 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92:519-525. https://doi.org/10.1067/moe.2001.116062
  10. Raderer M, Kiesewetter B, Ferreri AJ. Clinicopathologic characteristics and treatment of marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). CA Cancer J Clin. 2016;66:153-171.
  11. Vega F, Lin P, Medeiros LJ. Extranodal lymphomas of the head and neck. Ann Diagn Pathol. 2005;9:340-350. https://doi.org/10.1016/j.anndiagpath.2005.09.020
  12. Suh C, Huh J, Roh JL. Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue arising in the extracranial head and neck region: A high rate of dissemination and disease recurrence. Oral Oncol. 2008;44:949-955. https://doi.org/10.1016/j.oraloncology.2007.11.011
  13. Sunaba K, Shibuya H, Okada N, Amagasa T, Enomoto S, Kishimoto S. Radiotherapy for primary localized (stage I and II) non-Hodgkin's lymphoma of the oral cavity. Int J Radiat Oncol Biol Phys. 2000;47:179-183. https://doi.org/10.1016/S0360-3016(00)00412-0
  14. National Comprehensive Cancer Network. Clinical practice guidelines in oncology. B-cell lymphomas. version 5. 2021. [serial online] 2021 Sep [cited 2021 Sep 25]. Available from: URL: https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf