Journal of TMJ Balancing Medicine (턱관절균형의학회지)

Association of TMJ Balancing Medicine (턱관절균형의학회)
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Usefulness of Network Pharmacology Analysis in Exploring Herbal Medicine Resources for the Treatment of Dementia

치매 치료를 위한 한약 자원 탐색에서 네트워크 약리학 분석법의 유용성

  • Suin Cho (Department of Korean Medicine, School of Korean Medicine, Pusan National University)
  • 조수인 (부산대학교 한의학전문대학원 한의학과)
  • Received : 2021.12.21
  • Accepted : 2022.01.18
  • Published : 2022.12.20
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Abstract

Objectives: Dementia is a disease in which a person maintains a normal intellectual level during the growth period, but has acquired cognitive impairment and personality change. In this study, we tried to check whether the network pharmacology analysis method is useful in the search for herbal medicine resources for the treatment of dementia. Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) database is a database frequently used in Chinese medicine research. We used the TCMSP to identify herbal medicines and their molecular targets that can be used for dementia by using network pharmacology research methods. Results: It was possible to select 28 types of components that are expected to be active by applying them to the living body, and 75 types of targets that these components act on were secured. In addition, 16 kinds of drugs were identified by checking the drugs containing 28 kinds of ingredients, and it was found that Radix Salviae contained 2 kinds of the selected 28 kinds of ingredients. Conclusions: Through this study, we were able to identify ingredients, drugs, and targets that can be used for basic and clinical research on dementia.

Keywords

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