Advances in materials Research

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Evaluating the absorption loading technique to acrylic resin for drug delivery

  • Al-Kaabi, Arshad F. (Department of Dental Technology, College of Health and Medical Technology, Middle Technical University) ;
  • Hamid, Mohammed A. (Department of Dental Technology, College of Health and Medical Technology, Middle Technical University)
  • Received : 2020.09.10
  • Accepted : 2022.01.09
  • Published : 2022.06.25
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Abstract

Acrylic resin or polymethylmethacrylate (PMMA) is one of the most attractive materials to be used for dental appliances manufacturing. It has been introduced as a biomaterial during the last century. This study aims to evaluate the compounds absorption and release through acrylic resin to be used for drug delivery as well. The study specimens were 10 pieces of heat-cured clear acrylic resin with dimensions of 10 × 10 × 2 mm. The specimens were dipped in methylene blue solution at a powder-water ratio of 1:20 for 5 days. The samples were removed and dipped in 5 ml distilled water vials for 24 hours. Then the specimens were replaced into new 5 ml vials and the process lasted for 4 days. The extracted solutions were analyzed by the visible light spectroscopy for absorbance. The statistical results showed a gradual increase in stain release from day 1 to day 4 with a significant difference between day 1 and day 4 solutions. The study showed that PMMA resin is able to absorb and release some compounds constantly and the absorption drug-loading technique is applicable to this material.

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References

  1. Abd Kati, F. and Al-Kaabi, A.F.J. (2016), "Effect of oil paint addition on micro hardness of acrylic ocular prosthesis", Iraqi Dent. J., 38(2), 87-89. http://dx.doi.org/10.26477/idj.v38i2.83
  2. Ahmed, A.R., Elkharraz, K., Irfan, M. and Bodmeier, R. (2012), "Reduction in burst release after coating poly(D,L-lactide-co-glycolide) (PLGA) microparticles with a drug-free PLGA layer", Pharm. Dev. Technol., 17(1), 66-72. https://doi.org/10.3109/10837450.2010.513989
  3. Akpan, A. and Morgan, R. (2002), "Oral candidiasis", Postgrad. Med. J., 78(922), 455-459. http://dx.doi.org/10.1136/pmj.78.922.455
  4. Al-Kaabi, A. and Hamid, M. (2020), "Active components delivery rate from acrylic resin maxillary surgical obturator: Part I", Adv. Mater. Res., Int. J., 9(2), 109-114. https://doi.org/10.12989/amr.2020.9.2.109
  5. Aljorani, L.E. and Al-Kaabi, A.F.J. (2018), "Non-polar micro-coating on acrylic denture material for reducing the incidence of dental biofilm formation", Mustansiria Dent. J., 15(1), 77-82.
  6. Ariamanesh, H., Tamizi, N., Yazdinezhad, A., Salah, S., Motamed, N. and Amanloo, S. (2019), "The Effectiveness of Nigella Sativa Alcoholic Extract on the Inhibition of Candida Albicans Colonization and Formation of Plaque on Acrylic Denture Plates: an In Vitro Study", J. Dent., 20(3), 171-177. https://doi.org/10.30476/DENTJODS.2019.44911
  7. Budtz-Jorgensen, E. (1974), "The significance of Candida albicans in denture stomatitis", Eur. J. Oral Sci., 82, 151-190. https://doi.org/10.1111/j.1600-0722.1974.tb00378.x
  8. Budtz-Jorgensen, E., Theilade, E. and Theilade, J. (1983), "Regional variations in viable bacterial and yeast counts of 1-week-old denture plaque in denture stomatitis", Eur. J. Oral Sci., 91, 288-295. https://doi.org/10.1111/j.1600-0722.1983.tb00818.x
  9. Darwazeh, A.M.G., Al-Refai, S. and Al-Mojaiwel, S. (2001), "Isolation of Candida species from the oral cavity and fingertips of complete denture wearers", J. Prosthet. Dent., 86(4), 420-423. https://doi.org/10.1067/mpr.2001.118020
  10. Di Francesco, M., Primavera, R., Summa, M., Pannuzzo, M., Di Francesco, V., Di Mascolo, D., Bertorelli, R. and Decuzzi, P. (2020), "Engineering shape-defined PLGA microPlates for the sustained release of antiinflammatory molecules", J. Control. Release, 319, 201-212. https://doi.org/10.1016/j.jconrel.2019.12.039
  11. Elmadani, A.A., Radovic, I., Tomic, N.Z., Petrovic, M., Stojanovic, D.B., Heinemann, R.J. and Radojevic, V. (2019), "Hybrid denture acrylic composites with nanozirconia and electrospun polystyrene fibers", PLoS One, 14(12), e0226528. https://doi.org/10.1371/journal.pone.0226528
  12. Kumar, A., Kumar, R., Vamshikiran, K., Deepthi, G., Kumar, N. and Akhilesh, M. (2019), "Evaluation of Impact Strength of Dental Acrylic Resins by Incorporation of TiO2 Nanoparticles Using Two Different Processing Techniques", J. Contemp. Dent. Pract., 20(10), 1184-1189. https://doi.org/10.5005/jp-journals-10024-2655
  13. Kurt, A., Erkose-Genc, G., Uzun, M., Sari, T. and Isik-Ozkol, G. (2018), "The Effect of Cleaning Solutions on a Denture Base Material: Elimination of Candida albicans and Alteration of Physical Properties", J. Prosthodont., 27(6), 577-583. https://doi.org/10.1111/jopr.12539
  14. Li, Z., Sun, J., Lan, J. and Qi, Q. (2016), "Effect of a denture base acrylic resin containing silver nanoparticles on Candida albicans adhesion and biofilm formation", Gerodontology, 33(2), 209-216. https://doi.org/10.1111/ger.12142
  15. Maldonado, K., Xu, D., Wang, Y., Zhang, J.F., Hamdan, S., Wen, Z.T., Fidel, P.L., Noverr, M.C. and Xu, X. (2018), "Mechanical and physical properties of experimental antifungal denture base resins", Oral Health Dent. Stud., 1(1), p. 5.
  16. Namangkalakul, W., Benjavongkulchai, S., Pochana, T., Promchai, A., Satitviboon, W., Howattanapanich, S., Phuprasong, R., Ungvijanpunya, N., Supakanjanakanti, D., Chaitrakoonthong, T. and Muangsawat, S. (2020), "Activity of chitosan antifungal denture adhesive against common Candida species and Candida albicans adherence on denture base acrylic resin", J. Prosthet. Dent., 123(1), 181.e1. https://doi.org/10.1016/j.prosdent.2019.09.026
  17. Nawasrah, A., AlNimr, A. and Ali, A.A. (2016), "Antifungal effect of henna against Candida albicans adhered to acrylic resin as a possible method for prevention of denture stomatitis", Int. J. Environ. Res. Public Health., 13(5), p. 520. https://doi.org/10.3390/ijerph13050520
  18. Palaskar, J.N., Singh, S. and Mittal, S. (2019), "Evaluation and comparison of different polymerization techniques, curing cycles, and thicknesses of two denture base materials", Indian J. Dent. Res., 30(4), 583-589. https://doi.org/10.4103/ijdr.IJDR_170_16
  19. Pollack, B., Buck, I.F. and Kalnius, J. (1964), "An oral syndrome complicating pschopharmacotherapy: study II", Am J Psychiatry, 121, 384-386. https://doi.org/10.1176/ajp.121.4.384
  20. Procopio, A.L.F., Da Silva, R.A., Maciel, J.G., Sugio, C.Y.C., Soares, S., Urban, V.M. and Neppelenbroek, K.H. (2018), "Antimicrobial and cytotoxic effects of denture base acrylic resin impregnated with cleaning agents after long-term immersion", Toxicol. Vitro, 52, 8-13. https://doi.org/10.1016/j.tiv.2018.05.012
  21. Webb, B.C., Thomas, C.J., Willcox, M.D.P., Harty, D.W.S. and Knox, K.W. (1998), "Candida-associated denture stomatitis. Aetiology and management: a review. Part 2. Oral diseases caused by Candida species", Aust. Dent. J., 43(3), 160-166. https://doi.org/10.1111/j.1834-7819.1998.tb00157.x