Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Asterias pectinifera-Derived Collagen Peptides Mixed with Halocynthia roretzi Extracts Exhibit Anti-Photoaging Activities during Exposure to UV Irradiation, and Antibacterial Properties

  • Soo-Jin Oh (BK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University Guro Hospital) ;
  • Ji-Ye Park (BK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University Guro Hospital) ;
  • Bada Won (R&D Center, Star's Tech Co., Ltd.) ;
  • Yong-Taek Oh (R&D Center, Star's Tech Co., Ltd.) ;
  • Seung-Chan Yang (R&D Center, Star's Tech Co., Ltd.) ;
  • Ok Sarah Shin (BK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University Guro Hospital)
  • Received : 2022.07.08
  • Accepted : 2022.09.30
  • Published : 2022.11.28
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Abstract

Asterias pectinifera, a species of starfish and cause of concern in the aquaculture industry, was recently identified as a source of non-toxic and highly water-soluble collagen peptides. In this study, we investigated the antioxidant and anti-photoaging functions of compounds formulated using collagen peptides from extracts of Asterias pectinifera and Halocynthia roretzi (AH). Our results showed that AH compounds have various skin protective functions, including antioxidant effects, determined by measuring the scavenging activity of 2,2-diphenyl-1-picrylhydrazyl radicals, as well as anti-melanogenic effects, determined by measuring tyrosinase inhibition activity. To determine whether ethosome-encapsulated AH compounds (E(AH)) exert ultraviolet (UV)-protective effects, human dermal fibroblasts or keratinocytes were incubated with E(AH) before and after exposure to UVA or UVB. E(AH) treatment led to inhibition of photoaging-induced secretion of matrix metalloproteinase-1 and interleukin-6 and -8, which are associated with inflammatory responses during UV irradiation. Finally, the antibacterial effects of AH and E(AH) were confirmed against both gram-negative and gram-positive bacteria. Our results indicate that E(AH) has the potential for use in the development of cosmetics with a range of skin protective functions.

Keywords

Acknowledgement

This research was supported by the Korea Institute of Marine Science & Technology Promotion (KIMST) funded by the Ministry of Oceans and Fisheries (20210276).

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