Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics (대한후두음성언어의학회지)

The Korean Society of Laryngology, Phoniatrics and Logopedics. (대한후두음성언어의학회)
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Effect of Proton Pump Inhibitors, Mucolytics and Steroids on Voice Outcomes After Laryngomicrosurgery

후두미세수술 후 양성자펌프억제제, 점액용해제, 스테로이드가 음성에 미치는 영향

  • Choi, Yeon Soo (Department of Otorhinolaryngology-Head and Neck Surgery, Inha University College of Medicine) ;
  • Kim, Ji Won (Department of Otorhinolaryngology-Head and Neck Surgery, Inha University College of Medicine)
  • 최연수 (인하대학교 의과대학 이비인후과학교실) ;
  • 김지원 (인하대학교 의과대학 이비인후과학교실)
  • Received : 2022.02.27
  • Accepted : 2022.04.06
  • Published : 2022.04.30
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Abstract

Background and Objectives Proton pump inhibitors (PPIs), mucolytics, and steroids were commonly recommended after phonomicrosurgery to prevent worsening of vocal fold (VF) scar formation and subglottal swelling. However, there is no consensus about whether laryngeal reflux and thick discharge are associated with the voice outcomes following phonomicrosurgery in benign VF lesions. The purpose of this study is to examine voice outcomes of use of PPIs, mucolytics,and steroids after phonomicrosurgery. Materials and Method This randomized controlled study is performed with patients undergoing laryngomicroscopic surgery for VF polyp and cyst. Participants were randomly assigned to 1) no medication, 2) PPIs, 3) PPIs+mucolytics, and 4) PPIs+mucolytics+steroids for 2 months postoperatively. Grade, roughness, breathiness, asthenia, and strain (GRBAS) scale, stroboscopic examination, aerodynamic assessment, acoustic analysis, and Voice Handicap Index-10 (VHI-10) were performed pre- and post-operatively at 2 months. Parameters were compared among four groups. Results Among 85 patients, a total of 50 patients were included. The VHI-10, perceptual and acoustic parameters improved in all groups after surgery. However, there was no significant difference in those parameters among all groups. Conclusion PPIs, mucolytics, and steroids did not significantly influence voice outcomes after phonomicrosurgery in patients with benign VF lesions.

Keywords

Acknowledgement

This study was supported by INHA UNIVERSITY Research Grant and IL-YANG Pharmaceutical Co., Ltd.

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