한국식품영양학회지 (The Korean Journal of Food And Nutrition)

  • 제35권1호
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  • Pages.7-15
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  • 2022
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  • 1225-4339(pISSN)
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  • 2287-4992(eISSN)
한국식품영양학회 (The Korean Society of Food and Nutrition)
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마카 품종별 조다당 획분의 대식세포 활성

Macrophage Stimulating Activity of Crude Polysaccharide on Maca (Lepidium meyenii) Varieties

  • 신현영 (고려대학교 대학원 의생명융합과학과 러닝헬스시스템융합전공) ;
  • 김훈 (중앙대학교 생명공학대학) ;
  • 정은진 (한국교통대학교 식품영양학전공) ;
  • 유광원 (한국교통대학교 식품영양학전공)
  • Shin, Hyun Young (Transdisciplinary Major in Learning Health Systems, Dept. of Integrated Biomedical and Life Science, Graduate School, Korea University) ;
  • Kim, Hoon (College of Biotechnology and Natural Resources, Chung-Ang University) ;
  • Jeong, Eun-Jin (Major in Food and Nutrition, Korea National University of Transportation) ;
  • Yu, Kwang-Won (Major in Food and Nutrition, Korea National University of Transportation)
  • 투고 : 2021.11.30
  • 심사 : 2022.01.13
  • 발행 : 2022.02.28
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초록

Maca roots (Lepidium meyenii) are an important medicinal herb that have long been used by the Andes-indigenous peoples and South Americans. In Korea, recently, it has attracted attention as a health food material because of nutritional values and physiological activities. The purpose of this study was to investigate the industrial applicability of maca (red and golden varieties; R&G) as immunostimulating materials. In the macrophage stimulating assay using RAW 264.7 cells at 125~500 ㎍/mL of non-cytotoxicity doses, G-HW showed the most potent production of TNF-α, IL-6 and nitric oxide compared to red maca or the other extracts. The general component analysis results showed that all extracts comprised more than 90% neutral sugars with small amounts of uronic acid and protein. Meanwhile, component sugar analysis showed the difference in the content of uronic acids of cold- and hot-water extract. Additionally, the further fractionation of G-HW into crude polysaccharide (G-CP) greatly enhanced the macrophage stimulating activity, and G-CP contained macromolecules over 144 kDa, comprised mainly of glucose and galacturonic acid (51.0 and 34.9%). In conclusion, crude polysaccharide from maca showed industrial applicability as immunostimulating material, and especially golden maca showed higher macrophage stimulating activity than red maca.

키워드

과제정보

본 연구는 2021년 한국교통대학교 지원을 받아 수행하였음.

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