Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Primary copper-associated chronic hepatitis without copper metabolism domain containing 1 mutation in a Dalmatian: a case report

  • Sumin, Yun (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Dohee, Lee (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Jimin, Oh (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Yeon, Chae (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Taesik, Yun (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Yoonhoi, Koo (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Mhan-Pyo, Yang (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Byeong-Teck, Kang (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Hakhyun, Kim (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
  • Received : 2022.06.21
  • Accepted : 2022.12.01
  • Published : 2022.12.31
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Abstract

A 12-year-old intact male Dalmatian dog presented hyporexia and vomiting for 1 week. Blood analysis revealed increased liver enzyme activity. Histopathological examination of the liver confirmed chronic hepatitis with fibrosis and necrosis. Copper staining revealed marked copper accumulation (2,770 ppm; normal range, 200 to 400 ppm), prominent in the centrilobular region, and compatible with copper-associated chronic hepatitis. However, copper metabolism domain containing 1 (COMMD1) mutation predisposing to copper accumulation in the liver tissue was not identified. The dog received medications but died 1 month after first visit. This is the first case of primary copper-associated hepatitis without COMMD1 mutation in a Dalmatian dog in South Korea.

Keywords

Acknowledgement

The authors would like to thank the owners of the dog included in this report. This work was supported by the Global Research and Development Center (GRDC) Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT (2017K1A4A3014959) and Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through Agriculture, Food and Rural Affairs Convergence Technologies Program for Educating Creative Global Leader, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (grant number: 320005-4).

References

  1. Dirksen K, Fieten H. Canine copper-associated hepatitis. Vet Clin North Am Small Anim Pract 2017;47:631-644.  https://doi.org/10.1016/j.cvsm.2016.11.011
  2. Wu X, den Boer ER, Vos-Loohuis M, Steenbeek FG, Monroe GR, Nijman IJ, Leegwater PA, Fieten H. Investigation of genetic modifiers of copper toxicosis in Labrador retrievers. Life (Basel) 2020;10:266. 
  3. Nakaichi M, Iseri T, Horikirizono H, Komine M, Itoh H, Sunahara H, Nemoto Y, Itamoto K, Tani K. Copper-associated hepatitis in a young Dalmatian dog in Japan. J Vet Med Sci 2021;83:911-915.  https://doi.org/10.1292/jvms.21-0061
  4. Rodrigues A, Leal RO, Girod M, Dally C, Guery E, Gomes E, Hernandez J. Canine copper-associated hepatitis: a retrospective study of 17 clinical cases. Open Vet J 2020;10:128-134. 
  5. Fieten H, Leegwater PA, Watson AL, Rothuizen J. Canine models of copper toxicosis for understanding mammalian copper metabolism. Mamm Genome 2012;23:62-75.  https://doi.org/10.1007/s00335-011-9378-7
  6. Hoffmann G. Copper-associated liver diseases. Vet Clin North Am Small Anim Pract 2009;39:489-511.  https://doi.org/10.1016/j.cvsm.2009.02.001
  7. Webster CRL, Center SA, Cullen JM, Penninck DG, Richter KP, Twedt DC, Watson PJ. ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs. J Vet Intern Med 2019;33:1173-1200.  https://doi.org/10.1111/jvim.15467
  8. Wu X, Mandigers PJJ, Fieten H, Leegwater PA. Evaluation of COMMD1 in copper toxicosis in Labrador retrievers and Dobermans. Vet J 2020;265:105561.  https://doi.org/10.1016/j.tvjl.2020.105561
  9. Forman OP, Boursnell ME, Dunmore BJ, Stendall N, van den Sluis B, Fretwell N, Jones C, Wijmenga C, Rothuizen J, van Oost BA, Holmes NG, Binns MM, Jones P. Characterization of the COMMD1 (MURR1) mutation causing copper toxicosis in Bedlington terriers. Anim Genet 2005;36:497-501.  https://doi.org/10.1111/j.1365-2052.2005.01360.x
  10. Hill TL, Breitschwerdt EB, Cecere T, Vaden S. Concurrent hepatic copper toxicosis and Fanconi's syndrome in a dog. J Vet Intern Med 2008;22:219-222.  https://doi.org/10.1111/j.1939-1676.2007.0040.x
  11. Vincent AM, Sordillo LM, Smedley RC, Gandy JC, Brown JL, Langlois DK. Peripheral markers of oxidative stress in Labrador retrievers with copper-associated hepatitis. J Small Anim Pract 2021;62:866-873.  https://doi.org/10.1111/jsap.13361
  12. Rifkin J, Miller MD. Copper-associated hepatitis in a Pembroke Welsh corgi. Can Vet J 2014;55:573-576. 
  13. James FE, Knowles GW, Mansfield CS, Robertson ID. Ascites due to pre-sinusoidal portal hypertension in dogs: a retrospective analysis of 17 cases. Aust Vet J 2008;86:180-186.  https://doi.org/10.1111/j.1751-0813.2008.00284.x
  14. Webb CB, Twedt DC, Meyer DJ. Copper-associated liver disease in Dalmatians: a review of 10 dogs (1998-2001). J Vet Intern Med 2002;16:665-668.  https://doi.org/10.1892/0891-6640(2002)016<0665:CLDIDA>2.3.CO;2
  15. Bexfield NH, Buxton RJ, Vicek TJ, Day MJ, Bailey SM, Haugland SP, Morrison LR, Else RW, Constantino-Casas F, Watson PJ. Breed, age and gender distribution of dogs with chronic hepatitis in the United Kingdom. Vet J 2012;193:124-128. https://doi.org/10.1016/j.tvjl.2011.11.024