한국분말재료학회지 (Journal of Powder Materials)

  • 제29권6호
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  • Pages.499-504
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  • 2022
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  • 2799-8525(pISSN)
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  • 2799-8681(eISSN)
한국분말재료학회 (*구 분말야금학회) (The Korean Powder Metallurgy & Materials Institute)
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오일 성분의 고형 자가 유화 시스템을 위한 규산칼슘 함유 분말의 제조 및 평가

Fabrication and Evaluation of Powders Containing Calcium Silicate for Solid Self-emulsifying System of Oil

  • 진성규 (단국대학교 제약공학과)
  • Sung Giu, Jin (Department of Pharmaceutical Engineering, Dankook University)
  • 투고 : 2022.12.05
  • 심사 : 2022.12.20
  • 발행 : 2022.12.28
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초록

The objective of this study is to assess the impact of spray drying conditions on medium-chain triglyceride (MCT) loading, solubility, and release of an MCT-loaded solid self-emulsifying system in a water-insoluble oily substance. MCT-loaded solid self-emulsifying systems are prepared by spray drying with SDS and calcium silicate. The effects of inlet temperature (60, 80, or 100℃) and feed solution composition (0, 10, 50, 90, or 100% ethanol) on physicochemical properties of MCT-loaded solid self-emulsifying systems are studied. The inlet temperature significantly affects the water solubility of MCT. Moreover, the feed solution composition significantly affects water solubility, release rate, and MCT loading. The MCT-loaded solid self-emulsifying system obtained at 60℃ using 90% ethanol feed solution shows the best physicochemical properties among the synthesized products and exhibits better water solubility (4.43 ± 0.44 vs. 0 ㎍/mL) and release (94.4 ± 1.6 vs. 32.8 ± 7.4%, 60 min) than a commercial product. Furthermore, the MCT-loaded solid self-emulsifying system shows an excellent emulsion droplet size (approximately 230 nm).

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